日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3.

单价伪天然产物可加速 IDO1 的天然 E3 KLHDC3 的降解。

Hennes Elisabeth, Lucas Belén, Scholes Natalie S, Cheng Xiu-Fen, Scott Daniel C, Bischoff Matthias, Reich Katharina, Gasper Raphael, Lucas María, Xu Teng Teng, Rossini Sofia, Pulvermacher Lisa-Marie, Dötsch Lara, Imrichova Hana, Brause Alexandra, Führer Siska, Naredla Kesava Reddy, Sievers Sonja, Kumar Kamal, Janning Petra, Orabona Ciriana, Gersch Malte, Murray Peter J, Schulman Brenda A, Winter Georg E, Ziegler Slava, Waldmann Herbert

Design, Synthesis, and Structural Evolution of Pseudo-Natural Product IDO1 Inhibitors and Degraders

拟天然产物IDO1抑制剂和降解剂的设计、合成和结构演变

Cheng, Xiu-Fen; Lucas, Belén; Lampe, Philipp; Ugel, Stefano; Chen, Suyuan; Unger, Anke; Bischoff, Matthias; Adariani, Soheila Rezaei; Naredla, Kesava Reddy; Kumar, Kamal; Schmidt, Annika; Strohmann, Carsten; Janning, Petra; Gasper, Raphael; Lucas, María; Gersch, Malte; Sievers, Sonja; Bronte, Vincenzo; Ziegler, Slava; Waldmann, Herbert

Patient Perceptions of Blockchain-Based Health Information Exchange: User-Centered Design Study

患者对基于区块链的健康信息交换的认知:以用户为中心的设计研究

Guse, Richard; Hu, Shanshan; Thiebes, Scott; Erler, Christina; Caridia, Catherine; Stork, Wilhelm; Gersch, Martin; Sunyaev, Ali

Small Molecule-Induced Alterations of Protein Polyubiquitination Revealed by Mass-Spectrometric Ubiquitome Analysis

质谱泛素组分析揭示小分子诱导的蛋白质多聚泛素化改变

Führer, Siska; Gallant, Kai; Kaschani, Farnusch; Kaiser, Markus; Janning, Petra; Waldmann, Herbert; Gersch, Malte

Light-Activatable Ubiquitin for Studying Linkage-Specific Ubiquitin Chain Formation Kinetics

用于研究连接特异性泛素链形成动力学的光激活泛素

Banerjee, Sudakshina; Cakil, Zeyneb Vildan; Gallant, Kai; Boom, Johannes van den; Palei, Shubhendu; Meyer, Hemmo; Gersch, Malte; Summerer, Daniel

Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53.

USP53中K63连接导向的去泛素化酶活性的发现和机制

Wendrich Kim, Gallant Kai, Recknagel Sarah, Petroulia Stavroula, Kazi Nafizul Haque, Hane Jan André, Führer Siska, Bezstarosti Karel, O'Dea Rachel, Demmers Jeroen, Gersch Malte

Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30

嵌合去泛素化酶工程揭示了线粒体自噬调节因子USP30特异性抑制的结构基础

Nafizul Haque Kazi,Nikolas Klink,Kai Gallant,Gian-Marvin Kipka,Malte Gersch

Estimating myocardial fibrosis in aortic stenosis using the serum collagen type I C-terminal telopeptide to matrix metalloproteinase-1 ratio

利用血清I型胶原C端肽与基质金属蛋白酶-1的比值评估主动脉瓣狭窄患者的心肌纤维化程度

Gersch, Svante; Bengel, Philipp; Paul, Niels B; Ravassa, Susana; von Haehling, Stephan; Fischer, Andreas; Zeisberg, Elisabeth M; Puls, Miriam; Hasenfuß, Gerd; Schnelle, Moritz

Identification of a Monovalent Pseudo-Natural Product Degrader Class Supercharging Degradation of IDO1 by its native E3 KLHDC3

鉴定出一种单价伪天然产物降解剂,该降解剂可显著增强其天然 E3 酶 KLHDC3 对 IDO1 的降解作用

Hennes, Elisabeth; Lucas, Belén; Scholes, Natalie S; Cheng, Xiu-Fen; Scott, Daniel C; Bischoff, Matthias; Reich, Katharina; Gasper, Raphael; Lucas, María; Xu, Teng Teng; Pulvermacher, Lisa-Marie; Dötsch, Lara; Imrichova, Hana; Brause, Alexandra; Naredla, Kesava Reddy; Sievers, Sonja; Kumar, Kamal; Janning, Petra; Gersch, Malte; Murray, Peter J; Schulman, Brenda A; Winter, Georg E; Ziegler, Slava; Waldmann, Herbert

Low-flow in aortic valve stenosis patients with reduced ejection fraction does not depend on left ventricular function

主动脉瓣狭窄伴射血分数降低患者的低血流与左心室功能无关。

Gersch, Svante; Lange, Torben; Beuthner, Bo Eric; Elkenani, Manar; Paul, Niels; Schnelle, Moritz; Zeisberg, Elisabeth; Puls, Miriam; Hasenfuß, Gerd; Schuster, Andreas; Toischer, Karl