日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Expanding the toolbox to develop IAP-based degraders of TEAD transcription factors.

扩展工具箱,开发基于 IAP 的 TEAD 转录因子降解剂。

Gupta Nishma, Trainor Nicole, Radwan Mona, Nguyen Stephanie, Duncan Luke, Tang Andrew X, Beveridge Julia, Silke Natasha, Yousef Jumana, Bilgilier Ceren, Wachter Johannes, Greb Peter, Jandova Zuzana, Eliaš Ján, Kopf Sara, Gerstberger Thomas, Stolt-Bergner Peggy, Braun Nina, Weinstabl Harald, McConnell Darryl B, Mauri Federico, Lucet Isabelle S, Silke John, Chessum Nicola E A, Roy Michael J

Drugit: crowd-sourcing molecular design of non-peptidic VHL binders

Drugit:众包非肽类VHL结合剂的分子设计

Scott, Thomas; Smethurst, Christian Alan Paul; Westermaier, Yvonne; Mayer, Moriz; Greb, Peter; Kousek, Roland; Biberger, Tobias; Bader, Gerd; Jandova, Zuzana; Schmalhorst, Philipp S; Fuchs, Julian E; Magarkar, Aniket; Hoenke, Christoph; Gerstberger, Thomas; Combs, Steven A; Pape, Richard; Phul, Saksham; Kothiwale, Sandeepkumar; Bergner, Andreas; Waterson, Alex G; Weinstabl, Harald; McConnell, Darryl B; Meiler, Jens; Böttcher, Jark; Moretti, Rocco

Discovery of BI-2493, a Pan-KRAS Inhibitor Showing In Vivo Efficacy.

发现 BI-2493,一种泛 KRAS 抑制剂,显示出体内疗效

Bröker Joachim, Waterson Alex G, Hodges Timothy R, Abbott Jason R, Arnold Allison, Böttcher Jark, Braun Nina, Cui Jianwen, Fuchs Julian E, Gerstberger Thomas, Gogg Sebastian, Hanner Sabine, Herdeis Lorenz, Howell Lucas W, Mantoulidis Andreas, Mayer Moriz, Phan Jason, Rocchetti Francesca, Sankar Kyra, Sarkar Dhruba, Schaaf Otmar, Sensintaffar John L, Sun Qi, Wunberg Tobias, Fesik Stephen W

Lumbar paraspinal muscles in patients with chronic non-specific low back pain and the effect of exercise: comparative and interventional study

慢性非特异性腰痛患者腰椎旁肌功能及运动效果:一项比较和干预研究

Kokosova, Viktoria; Vlazna, Daniela; Krkoska, Peter; Sladeckova, Michaela; Dostal, Marek; Matulova, Katerina; Gerstberger, Radim; Ovesna, Petra; Adamova, Blanka

Chasing Red Herrings: Palladium Metal Salt Impurities Feigning KRAS Activity in Biochemical Assays.

追逐虚假信号:钯金属盐杂质在生化测定中伪装成 KRAS 活性

Gerstberger Thomas, Berger Helmut, Büttner Frank H, Gmachl Michael, Kessler Dirk, Koegl Manfred, Lucas Simon, Martin Laetitia J, Mayer Moriz, McConnell Darryl B, Mitzner Sophie, Scholz Guido, Treu Matthias, Wolkerstorfer Bernhard, Zahn Stephan, Zak Krzysztof M, Jaeger Philipp A, Ettmayer Peter

Benefit, recurrence pattern, and toxicity to adjuvant anti-PD-1 monotherapy varies by ethnicity and melanoma subtype: An international multicenter cohort study

辅助抗PD-1单药治疗的疗效、复发模式和毒性因种族和黑色素瘤亚型而异:一项国际多中心队列研究

Bai, Xue; Lawless, Aleigha R; Czapla, Juliane A; Gerstberger, Stefanie C; Park, Benjamin C; Jung, Seungyeon; Johnson, Rebecca; Yamazaki, Naoya; Ogata, Dai; Umeda, Yoshiyasu; Li, Caili; Guo, Jun; Flaherty, Keith T; Nakamura, Yasuhiro; Namikawa, Kenjiro; Long, Georgina V; Menzies, Alexander M; Johnson, Douglas B; Sullivan, Ryan J; Boland, Genevieve M; Si, Lu

Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer

逆转录酶抑制会破坏结直肠癌中重复元件的生命周期

Mihir Rajurkar #,Aparna R Parikh #,Alexander Solovyov #,Eunae You,Anupriya S Kulkarni,Chong Chu,Katherine H Xu,Christopher Jaicks,Martin S Taylor,Connie Wu,Katherine A Alexander,Charly R Good,Annamaria Szabolcs,Stefanie Gerstberger,Antuan V Tran,Nova Xu,Richard Y Ebright,Emily E Van Seventer,Kevin D Vo,Eric C Tai,Chenyue Lu,Jasmin Joseph-Chazan,Michael J Raabe,Linda T Nieman,Niyati Desai,Kshitij S Arora,Matteo Ligorio,Vishal Thapar,Limor Cohen,Padric M Garden,Yasmeen Senussi,Hui Zheng,Jill N Allen,Lawrence S Blaszkowsky,Jeffrey W Clark,Lipika Goyal,Jennifer Y Wo,David P Ryan,Ryan B Corcoran,Vikram Deshpande,Miguel N Rivera,Martin J Aryee,Theodore S Hong,Shelley L Berger,David R Walt,Kathleen H Burns,Peter J Park,Benjamin D Greenbaum,David T Ting

Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis

Thy1 标记小鼠表皮中一群独特的慢周期干细胞。

Elle Koren # ,Alona Feldman # ,Marianna Yusupova ,Avihay Kadosh ,Egor Sedov ,Roi Ankawa ,Yahav Yosefzon ,Waseem Nasser ,Stefanie Gerstberger ,Liam B Kimel ,Noa Priselac ,Samara Brown ,Sam Sharma ,Travis Gorenc ,Ruby Shalom-Feuerstein ,Hermann Steller ,Tom Shemesh ,Yaron Fuchs

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

选择性且口服生物可利用的 VHL 募集 PROTAC 在体内实现 SMARCA2 降解

Christiane Kofink #, Nicole Trainor #, Barbara Mair #, Simon Wöhrle, Melanie Wurm, Nikolai Mischerikow, Michael J Roy, Gerd Bader, Peter Greb, Géraldine Garavel, Emelyne Diers, Ross McLennan, Claire Whitworth, Vesna Vetma, Klaus Rumpel, Maximilian Scharnweber, Julian E Fuchs, Thomas Gerstberger, Yun

Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor

对 KRAS 上 Switch II 口袋的可逆结合进行片段优化,可产生有效的体内活性 KRASG12C 抑制剂

Joachim Bröker, Alex G Waterson, Chris Smethurst, Dirk Kessler, Jark Böttcher, Moriz Mayer, Gerhard Gmaschitz, Jason Phan, Andrew Little, Jason R Abbott, Qi Sun, Michael Gmachl, Dorothea Rudolph, Heribert Arnhof, Klaus Rumpel, Fabio Savarese, Thomas Gerstberger, Nikolai Mischerikow, Matthias Treu, L