Human ESCs predisposition to karyotypic instability: Is a matter of culture adaptation or differential vulnerability among hESC lines due to inherent properties?

人类胚胎干细胞核型不稳定的倾向：是培养适应的问题，还是由于固有特性导致的人类胚胎干细胞系之间的差异性脆弱性？