日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Proof-of-Mechanism Study of the Phosphodiesterase 10 Inhibitor RG7203 in Patients With Schizophrenia and Negative Symptoms

磷酸二酯酶 10 抑制剂 RG7203 对伴有阴性症状的精神分裂症患者的作用机制验证研究

Umbricht, Daniel; Abt, Markus; Tamburri, Paul; Chatham, Christopher; Holiga, Štefan; Frank, Michael J; Collins, Anne G E; Walling, David P; Mofsen, Rick; Gruener, Daniel; Gertsik, Lev; Sevigny, Jeff; Keswani, Sanjay; Dukart, Juergen

Traditional Approaches for Company Valuation Are Flawed for Valuing In Vivo Gene Therapy Companies

传统的公司估值方法不适用于体内基因治疗公司的价值评估。

Amusa, Gbolahan; Feehley, Taylor; Bitok, J Kipchirchir; Livshits, Geulah; Gertsik, Natalya

Mapping the Binding Site of BMS-708163 on γ-Secretase with Cleavable Photoprobes

利用可裂解光探针绘制BMS-708163在γ-分泌酶上的结合位点图谱

Gertsik, Natalya; Am Ende, Christopher W; Geoghegan, Kieran F; Nguyen, Chuong; Mukherjee, Paramita; Mente, Scot; Seneviratne, Uthpala; Johnson, Douglas S; Li, Yue-Ming

A Randomized Multiple Dose Pharmacokinetic Study of a Novel PDE10A Inhibitor TAK-063 in Subjects with Stable Schizophrenia and Japanese Subjects and Modeling of Exposure Relationships to Adverse Events

一项针对稳定期精神分裂症患者和日本受试者的新型PDE10A抑制剂TAK-063的随机多剂量药代动力学研究,以及对暴露量与不良事件关系的建模。

Goldsmith, Paul; Affinito, John; McCue, Maggie; Tsai, Max; Roepcke, Stefan; Xie, Jinhui; Gertsik, Lev; Macek, Thomas A

γ-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of γ-Secretase and Signal Peptide Peptidase

γ-分泌酶抑制剂和调节剂可诱导γ-分泌酶和信号肽肽酶活性位点发生不同的构象变化。

Gertsik, Natalya; Chau, De-Ming; Li, Yue-Ming

Development of CBAP-BPyne, a probe for γ-secretase and presenilinase

CBAP-BPyne 的开发,一种用于检测 γ-分泌酶和早老素酶的探针

Gertsik, Natalya; Ballard, T Eric; Am Ende, Christopher W; Johnson, Douglas S; Li, Yue-Ming

Open-label, randomized, parallel-group controlled clinical trial of massage for treatment of depression in HIV-infected subjects

一项开放标签、随机、平行组对照的临床试验,研究按摩治疗艾滋病毒感染者抑郁症的效果

Poland, Russell E; Gertsik, Lev; Favreau, Joya T; Smith, Shawnee I; Mirocha, James M; Rao, Uma; Daar, Eric S

Omega-3 fatty acid augmentation of citalopram treatment for patients with major depressive disorder

ω-3脂肪酸增强西酞普兰治疗重度抑郁症患者

Gertsik, Lev; Poland, Russell E; Bresee, Catherine; Rapaport, Mark Hyman

Maximum tolerated dose evaluation of the AMPA modulator Org 26576 in healthy volunteers and depressed patients: a summary and method analysis of bridging research in support of phase II dose selection

在健康志愿者和抑郁症患者中评估 AMPA 调节剂 Org 26576 的最大耐受剂量:支持 II 期剂量选择的桥接研究的总结和方法分析

Nations, Kari R; Bursi, Roberta; Dogterom, Peter; Ereshefsky, Larry; Gertsik, Lev; Mant, Tim; Schipper, Jacques