日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.

利用 iPSC 衍生神经元进行 CRISPR 筛选揭示了 tau 蛋白稳态的原理。

Samelson Avi J, Ariqat Nabeela, McKetney Justin, Rohanitazangi Gita, Parra Bravo Celeste, Bose Rudra S, Travaglini Kyle J, Lam Victor L, Goodness Darrin, Ta Thomas, Dixon Gary, Marzette Emily, Jin Julianne, Tian Ruilin, Tse Eric, Abskharon Romany, Pan Henry S, Carroll Emma C, Lawrence Rosalie E, Gestwicki Jason E, Rexach Jessica E, Eisenberg David S, Kanaan Nicholas M, Southworth Daniel R, Gross John D, Gan Li, Swaney Danielle L, Kampmann Martin

Survey of the human proteostasis network: the ubiquitin-proteasome system

人类蛋白质稳态网络概览:泛素-蛋白酶体系统

Elsasser, Suzanne; Powers, Evan T; Stoeger, Thomas; Sui, Xiaojing; Kurtzbard, Roy D; Martínez-Botía, Patricia; Wangeline, Margaret A; Gama, Alejandro Rodriguez; Huttlin, Edward L; Elia, Lisa P; Kelly, Jeffery W; Gestwicki, Jason E; Frydman, Judith; Finkbeiner, Steven; Clerico, Eugenia M; Morimoto, Richard I; Prado, Miguel A; Vertegaal, Alfred C O; Hofmann, Kay; Finley, Daniel

Protein-adaptive differential scanning fluorimetry using conformationally responsive dyes.

利用构象响应染料的蛋白质自适应差示扫描荧光法

Wu Taiasean, Yu Joshua C, Suresh Arundhati, Gale-Day Zachary J, Alteen Matthew G, Woo Amanda S, Millbern Zoe, Johnson Oleta T, Carroll Emma C, Partch Carrie L, Fourches Denis, Vinueza Nelson R, Vocadlo David J, Gestwicki Jason E

High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs.

利用高通量方法发现可识别淀粉样蛋白原纤维多晶型的荧光探针。

Carroll Emma C, Yang Hyunjun, Powell Wyatt C, Charvat Annemarie F, Oehler Abby, Jones Julia G, Montgomery Kelly M, Yung Anthony, Millbern Zoe, Taylor Alexander I P, Wilkinson Martin, Ranson Neil A, Radford Sheena E, Vinueza Nelson R, DeGrado William F, Mordes Daniel A, Condello Carlo, Gestwicki Jason E

Pathogenic mutation impairs functional dynamics of Hsp60 in mono- and oligomeric states

致病性突变会损害Hsp60在单体和寡聚状态下的功能动力学。

Torielli, Luca; Guarra, Federica; Shao, Hao; Gestwicki, Jason E; Serapian, Stefano A; Colombo, Giorgio

Radical Strategy to the Boron-to-Copper Transmetalation Problem: N-Alkylation with Alkylboronic Esters

解决硼铜金属转移问题的激进策略:烷基硼酸酯的N-烷基化

Sang, Ruocheng; Gestwicki, Jason E

Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy

抑制DNAJ-HSP70相互作用可改善肌营养不良症患者的力量

Bengoechea, Rocio; Findlay, Andrew R; Bhadra, Ankan K; Shao, Hao; Stein, Kevin C; Pittman, Sara K; Daw, Jil Aw; Gestwicki, Jason E; True, Heather L; Weihl, Conrad C

Recombinant antibodies inhibit enzymatic activity of the E3 ubiquitin ligase CHIP via multiple mechanisms

重组抗体通过多种机制抑制E3泛素连接酶CHIP的酶活性。

Chung, Dong Hee; Connelly, Emily J; Unnikrishnan, Aparna; Chuo, Shih-Wei; Wucherer, Kristin; Nadel, Cory M; Gestwicki, Jason E; Southworth, Daniel R; Craik, Charles S

Aurora 2.0: A fluorogenic dye library for expanding the capability of protein-adaptive differential scanning fluorimetry (paDSF)

Aurora 2.0:用于扩展蛋白质自适应差示扫描荧光法 (paDSF) 功能的荧光染料库

Charvat, Annemarie F; Mason-Chalmers, Kayleigh; Grabinska-Rogala, Aneta; Shivakumar, Shloka; Gale-Day, Zachary; Wu, Taiasean; Millbern, Zoe; Grimm, Jonathan B; Carroll, Emma C; Nilsson, K Peter R; Lavis, Luke D; Vinueza, Nelson R; Gestwicki, Jason E

Structures of Fab-stabilized CHIP reveal a conformational switch important in E3 ligase and chaperone functions

Fab稳定化的CHIP的结构揭示了一种构象转换,该转换对E3连接酶和分子伴侣功能至关重要。

Unnikrishnan, Aparna; Chung, Dong Hee; Connelly, Emily J; Chuo, Shih-Wei; Devi, Shweta; Thwin, Aye C; Nadel, Cory M; Tse, Eric; Gestwicki, Jason E; Craik, Charles S; Southworth, Daniel R