日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pharmacological inhibition of USP18 improves antibacterial responses and the intracellular control of Mycobacterium tuberculosis in macrophages

药理学抑制USP18可改善巨噬细胞的抗菌反应和对结核分枝杆菌的细胞内控制。

Zhang, Qiao; Gong, Zhen; Schnell, Robert; Zhong, Yi; Geurink, Paul P; Lauschke, Volker M; Xie, Jianping; Gastaldello, Stefano; Rottenberg, Martin E

High-Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15-Specific Protease mUSP18

利用氰胺库的高通量合成和筛选鉴定出ISG15特异性蛋白酶mUSP18的选择性抑制剂

Kooij, Raymond; Pol, Vito; Gan, Jin; van Doodewaerd, Bjorn R; Sapmaz, Aysegul; Campos Alonso, Marta; Fritz, Günter; Knobeloch, Klaus-Peter; Geurink, Paul P

High-throughput competitive binding assay for targeting RNA tertiary structures with small molecules: application to pseudoknots and G-quadruplexes

利用小分子靶向RNA三级结构的高通量竞争性结合分析:应用于假结和G-四链体

Wintermans, Sophie E L; Hoffmann, Jana S; van Kuijk, Victor; Durmus, Yelda; Tacoma, Mariska D; Broekhuizen, Indy; Janssen, Antonius P A; van den Elst, Hans; van Doodewaerd, Bjorn R; Geurink, Paul P; Artola, Marta; Olsthoorn, René C L

A drug-repurposing screen of FDA- and EMA-approved drugs identifies two NF-κB inhibitors active against eumycetoma

对已获FDA和EMA批准的药物进行药物再利用筛选,发现了两种对真菌性足菌肿有效的NF-κB抑制剂。

Ma, Jingyi; van Doodewaerd, Bjorn R; Biersack, Bernhard; Verbon, Annelies; Geurink, Paul P; van de Sande, Wendy W J

Development and Validation of a High-Throughput Screening Assay for the Legionella ADP-Ribosyl Transferase SdeA

军团菌ADP-核糖基转移酶SdeA高通量筛选检测方法的开发与验证

Vlaming, Halana C; Pol, Vito; van Doodewaerd, Bjorn R; Moutsiopoulou, Angeliki; Geurink, Paul P; Kim, Robbert Q; van der Heden van Noort, Gerbrand J

Differential gene expression analysis shows that cephalosporin resistance is intrinsic to Clostridioides difficile strain 630

差异基因表达分析表明,头孢菌素耐药性是艰难梭菌630株的固有特性。

Turello, Lara A; Consul, Amber; Yip, Christopher; Shen, Shirley; Seymour, Cale; Geurink, Corey; Alvarado, Israel; Abel-Santos, Ernesto

Bacterial esterases reverse lipopolysaccharide ubiquitylation to block host immunity.

细菌酯酶逆转脂多糖泛素化,从而阻断宿主免疫反应

Szczesna Magdalena, Huang Yizhou, Lacoursiere Rachel E, Bonini Francesca, Pol Vito, Koc Fulya, Ward Beatrice, Geurink Paul P, Pruneda Jonathan N, Thurston Teresa L M

Development of Inhibitors, Probes, and PROTAC Provides a Complete Toolbox to Study PARK7 in the Living Cell

抑制剂、探针和 PROTAC 的开发为研究活细胞中的 PARK7 提供了完整的工具箱

Yuqing Jia, Merve Oyken, Robbert Q Kim, Rayman T N Tjokrodirijo, Arnoud H de Ru, Antonius P A Janssen, Stephan M Hacker, Peter A van Veelen, Paul P Geurink, Aysegul Sapmaz

Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo

SARS-CoV-2 木瓜蛋白酶样蛋白酶的去泛素化活性不会影响病毒复制或体内先天免疫反应

Mariska van Huizen, Jonna R Bloeme-Ter Horst, Heidi L M de Gruyter, Paul P Geurink, Gerbrand J van der Heden van Noort, Robert C M Knaap, Tessa Nelemans, Natacha S Ogando, Anouk A Leijs, Nadya Urakova, Brian L Mark, Eric J Snijder, Sebenzile K Myeni, Marjolein Kikkert

A functional screen for ubiquitin regulation identifies an E3 ligase secreted by Pseudomonas aeruginosa

泛素调控功能筛选鉴定出铜绿假单胞菌分泌的 E3 连接酶

Cameron G Roberts, Supender Kaur, Aaron J Ogden, Michael E Divine, Gus D Warren, Donghoon Kang, Natalia V Kirienko, Paul P Geurink, Monique P C Mulder, Ernesto S Nakayasu, Jason E McDermott, Joshua N Adkins, Alejandro Aballay, Jonathan N Pruneda