日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective Inhibition of hsp90 Paralogs: Uncovering the Role of Helix 1 in Grp94-Selective Ligand Binding

选择性抑制hsp90旁系同源物:揭示螺旋1在Grp94选择性配体结合中的作用

Que, Nanette L S; Seidler, Paul M; Aw, Wen J; Chiosis, Gabriela; Gewirth, Daniel T

Structural transitions modulate the chaperone activities of Grp94

结构转变调节 Grp94 的分子伴侣活性

Amankwah, Yaa S; Fleifil, Yasmeen; Unruh, Erin; Collins, Preston; Wang, Yi; Vitou, Katherine; Bates, Alison; Obaseki, Ikponwmosa; Sugoor, Meghana; Alao, John Paul; McCarrick, Robert M; Gewirth, Daniel T; Sahu, Indra D; Li, Zihai; Lorigan, Gary A; Kravats, Andrea N

Second international symposium on the chaperone code, 2023

第二届国际陪护人员守则研讨会,2023年

Buchner, Johannes; Alasady, Milad J; Backe, Sarah J; Blagg, Brian S J; Carpenter, Richard L; Colombo, Giorgio; Gelis, Ioannis; Gewirth, Daniel T; Gierasch, Lila M; Houry, Walid A; Johnson, Jill L; Kang, Byoung Heon; Kao, Aimee W; LaPointe, Paul; Mattoo, Seema; McClellan, Amie J; Neckers, Leonard M; Prodromou, Chrisostomos; Rasola, Andrea; Sager, Rebecca A; Theodoraki, Maria A; Truman, Andrew W; Truttman, Matthias C; Zachara, Natasha E; Bourboulia, Dimitra; Mollapour, Mehdi; Woodford, Mark R

Selective targeting of GARP-LTGFβ axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8(+) T cell antitumor immunity

选择性靶向肿瘤微环境中的GARP-LTGFβ轴可通过增强CD8(+) T细胞抗肿瘤免疫力来增强PD-1阻断作用。

Li, Anqi; Chang, Yuzhou; Song, No-Joon; Wu, Xingjun; Chung, Dongjun; Riesenberg, Brian P; Velegraki, Maria; Giuliani, Giuseppe D; Das, Komal; Okimoto, Tamio; Kwon, Hyunwoo; Chakravarthy, Karthik B; Bolyard, Chelsea; Wang, Yi; He, Kai; Gatti-Mays, Margaret; Das, Jayajit; Yang, Yiping; Gewirth, Daniel T; Ma, Qin; Carbone, David; Li, Zihai

Chaperome heterogeneity and its implications for cancer study and treatment

分子伴侣异质性及其对癌症研究和治疗的影响

Wang, Tai; Rodina, Anna; Dunphy, Mark P; Corben, Adriana; Modi, Shanu; Guzman, Monica L; Gewirth, Daniel T; Chiosis, Gabriela

Structures of Hsp90α and Hsp90β bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity

Hsp90α和Hsp90β与嘌呤骨架抑制剂结合的结构揭示了一个可用于药物选择性的残基。

Huck, John D; Que, Nanette L S; Sharma, Sahil; Taldone, Tony; Chiosis, Gabriela; Gewirth, Daniel T

Potential impact of combined inhibition of 3α-oxidoreductases and 5α-reductases on prostate cancer

联合抑制3α-氧化还原酶和5α-还原酶对前列腺癌的潜在影响

Fiandalo, Michael V; Gewirth, Daniel T; Mohler, James L

Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94

分子伴侣 gp96/grp94 的底物和致癌作用

Ansa-Addo, Ephraim A; Thaxton, Jessica; Hong, Feng; Wu, Bill X; Zhang, Yongliang; Fugle, Caroline W; Metelli, Alessandra; Riesenberg, Brian; Williams, Katelyn; Gewirth, Daniel T; Chiosis, Gabriela; Liu, Bei; Li, Zihai

Exploring the Functional Complementation between Grp94 and Hsp90.

探索 Grp94 和 Hsp90 之间的功能互补性

Maharaj Kevin A, Que Nanette L S, Hong Feng, Huck John D, Gill Sabrina K, Wu Shuang, Li Zihai, Gewirth Daniel T