日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Transcriptional profiling reveals glucose-dependent regulation of COL13A1 mRNA in Pompe patients: Prospect for a novel disease mechanism

转录组分析揭示庞贝氏症患者中COL13A1 mRNA的葡萄糖依赖性调控:提示一种新的疾病机制

Uyttebroeck, S; Ngoc, D V; Osei, R; Dohr, K; Giron, P; Dequeker, B J H; Seneca, S; Sermon, K; Hes, F J; Gheldof, A

MTCH2 Suppresses Thermogenesis by Regulating Autophagy in Adipose Tissue.

MTCH2 通过调节脂肪组织中的自噬来抑制产热

Zhao Xin-Yuan, Zhao Ben-Chi, Li Hui-Lin, Liu Ying, Wang Bei, Li An-Qi, Zeng Tian-Shu, Hui Hannah Xiaoyan, Sun Jia, Cikes Domagoj, Gheldof Nele, Hager Jorg, Mi Jian-Xun, Laybutt D Ross, Deng Yin-Yue, Shi Yan-Chuan, Neely G Gregory, Wang Qiao-Ping

Development and validation of a high-throughput screening pipeline of compound libraries to target EMT

开发和验证靶向EMT化合物库的高通量筛选流程

Sven Jonckheere ,Joachim Taminau ,Jamie Adams ,Jef Haerinck ,Jordy De Coninck ,Jeroen Verstappe ,Kato De Clercq ,Evelien Peeters ,Alexander Gheldof ,Eva De Smedt ,Vera Goossens ,Dominique Audenaert ,Aurélie Candi ,Matthias Versele ,Dominic De Groote ,Hanne Verschuere ,Marc Stemmler ,Thomas Brabletz ,Peter Vandenabeele ,Andreu Casali ,Kyra Campbell ,Steven Goossens # ,Geert Berx #

Identification of RAD17 as a candidate cancer predisposition gene in families with histories of pancreatic and breast cancers

在有胰腺癌和乳腺癌家族史的家族中,RAD17被鉴定为候选癌症易感基因

Joris, Sofie; Giron, Philippe; Olsen, Catharina; Seneca, Sara; Gheldof, Alexander; Staessens, Shula; Shahi, Rajendra Bahadur; De Brakeleer, Sylvia; Teugels, Erik; De Grève, Jacques; Hes, Frederik J

Impaired catabolism of free oligosaccharides due to MAN2C1 variants causes a neurodevelopmental disorder

MAN2C1 变异导致游离寡糖分解代谢受损,从而引发神经发育障碍

Nuno Maia, Sven Potelle, Hamide Yildirim, Sandrine Duvet, Shyam K Akula, Celine Schulz, Elsa Wiame, Alexander Gheldof, Katherine O'Kane, Abbe Lai, Karen Sermon, Maïa Proisy, Philippe Loget, Tania Attié-Bitach, Chloé Quelin, Ana Maria Fortuna, Ana Rita Soares, Arjan P M de Brouwer, Emile Van Schaftin

The genetic diagnosis of rare endocrine disorders of sex development and maturation: a survey among Endo-ERN centres

罕见性发育和成熟内分泌疾病的基因诊断:Endo-ERN中心的一项调查

Persani, Luca; Cools, Martine; Ioakim, Stamatina; Faisal Ahmed, S; Andonova, Silvia; Avbelj-Stefanija, Magdalena; Baronio, Federico; Bouligand, Jerome; Bruggenwirth, Hennie T; Davies, Justin H; De Baere, Elfride; Dzivite-Krisane, Iveta; Fernandez-Alvarez, Paula; Gheldof, Alexander; Giavoli, Claudia; Gravholt, Claus H; Hiort, Olaf; Holterhus, Paul-Martin; Juul, Anders; Krausz, Csilla; Lagerstedt-Robinson, Kristina; McGowan, Ruth; Neumann, Uta; Novelli, Antonio; Peyrassol, Xavier; Phylactou, Leonidas A; Rohayem, Julia; Touraine, Philippe; Westra, Dineke; Vezzoli, Valeria; Rossetti, Raffaella

Proteomics reveals unique plasma signatures in constitutional thinness

蛋白质组学揭示体质瘦弱者独特的血浆特征

Ornella Cominetti, Antonio Núñez Galindo, John Corthésy, Jérôme Carayol, Natacha Germain, Bogdan Galusca, Bruno Estour, Jörg Hager, Nele Gheldof, Loïc Dayon

Myotonic dystrophy type 1 embryonic stem cells show decreased myogenic potential, increased CpG methylation at the DMPK locus and RNA mis-splicing.

1 型强直性肌营养不良胚胎干细胞表现出肌源性潜能降低、DMPK 位点 CpG 甲基化增加和 RNA 剪接错误

Franck Silvie, Couvreu De Deckersberg Edouard, Bubenik Jodi L, Markouli Christina, Barbé Lise, Allemeersch Joke, Hilven Pierre, Duqué Geoffrey, Swanson Maurice S, Gheldof Alexander, Spits Claudia, Sermon Karen D

Sustained intrinsic WNT and BMP4 activation impairs hESC differentiation to definitive endoderm and drives the cells towards extra-embryonic mesoderm

持续的内在 WNT 和 BMP4 激活会损害 hESC 向定形内胚层的分化,并促使细胞向胚外中胚层分化

C Markouli #, E Couvreu De Deckersberg #, D Dziedzicka, M Regin, S Franck, A Keller, A Gheldof, M Geens, K Sermon, C Spits

MSH2 knock-down shows CTG repeat stability and concomitant upstream demethylation at the DMPK locus in myotonic dystrophy type 1 human embryonic stem cells

MSH2 敲低显示 1 型肌强直性营养不良症人类胚胎干细胞中 CTG 重复稳定性和 DMPK 基因座的伴随上游去甲基化

Silvie Franck, Lise Barbé, Simon Ardui, Yannick De Vlaeminck, Joke Allemeersch, Dominika Dziedzicka, Claudia Spits, Fien Vanroye, Pierre Hilven, Geoffrey Duqué, Joris R Vermeesch, Alexander Gheldof, Karen Sermon