The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against Plasmodium falciparum via Dual Inhibition of PfArk1 and Hemozoin Formation
人源Chk1抑制剂CHIR-124通过双重抑制PfArk1和血红素形成,对恶性疟原虫表现出多阶段活性。
期刊:
影响因子:
doi:10.1101/2025.07.17.664511
Wicht, Kathryn J; Woodland, John G; Garnie, Larnelle F; Langeveld, Henrico; Taylor, Dale; Godoy, Luiz C; Pasaje, Charisse Flerida A; de Souza, Mariana Laureano; Siqueira-Neto, Jair L; Ghidelli-Disse, Sonja; Lafuente-Monasterio, Maria Jose; Gamo, Francisco-Javier; Coertzen, Dina; Reader, Janette; van der Watt, Mariëtte; Bridgford, Jessica L; Girling, Gareth; Coyle, Rachael; Scheurer, Christian; Wittlin, Sergio; Lee, Marcus C S; Voss, Till S; Winzeler, Elizabeth A; Fidock, David A; Niles, Jacquin C; Birkholtz, Lyn-Marié; Coulson, Lauren B; Chibale, Kelly