日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum

以 Aurora 激酶为关键细胞周期调节因子,开发针对恶性疟原虫的多阶段抗疟药物

Langeveld, Henrico; Maepa, Keletso; Maree, Marché; Thibaud, Jessica L; Salomane, Nicolaas; Bridgwater, Rosie; Famodimu, Mufuliat T; Godoy, Luiz C; Pasaje, Charisse Flerida A; Boonyalai, Nonlawat; de Souza, Mariana Laureano; Fong, Justin; Rabie, Tayla; van der Watt, Mariëtte; Theart, Rensu P; Ghidelli-Disse, Sonja; Niles, Jacquin C; Lee, Marcus C S; Winzeler, Elizabeth A; Delves, Michael J; Chibale, Kelly; Wicht, Kathryn J; Coulson, Lauren B; Birkholtz, Lyn-Marié

cAmbly: A non-toxic cell-penetrating peptide derived from Amblyomin-X with targeted delivery to mitochondrial and cytoplasmic proteins

cAmbly:一种源自 Amblyomin-X 的无毒细胞穿透肽,可靶向递送至线粒体和细胞质蛋白。

Buri, Marcus Vinicius; Garavelli, Graciana Yokota; Vigerelli, Hugo; de Souza, Marcelo Medina; Maia Lobba, Aline Ramos; Ghidelli-Disse, Sonja; Chudzinski-Tavassi, Ana Marisa

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against Plasmodium falciparum via Dual Inhibition of PfArk1 and Hemozoin Formation

人源Chk1抑制剂CHIR-124通过双重抑制PfArk1和血红素形成,对恶性疟原虫表现出多阶段活性。

Wicht, Kathryn J; Woodland, John G; Garnie, Larnelle F; Langeveld, Henrico; Taylor, Dale; Godoy, Luiz C; Pasaje, Charisse Flerida A; de Souza, Mariana Laureano; Siqueira-Neto, Jair L; Ghidelli-Disse, Sonja; Lafuente-Monasterio, Maria Jose; Gamo, Francisco-Javier; Coertzen, Dina; Reader, Janette; van der Watt, Mariëtte; Bridgford, Jessica L; Girling, Gareth; Coyle, Rachael; Scheurer, Christian; Wittlin, Sergio; Lee, Marcus C S; Voss, Till S; Winzeler, Elizabeth A; Fidock, David A; Niles, Jacquin C; Birkholtz, Lyn-Marié; Coulson, Lauren B; Chibale, Kelly

Plasmodium SEY1 is a novel druggable target that contributes to imidazolopiperazine mechanism of action

疟原虫 SEY1 是一种新型可用药靶点,有助于咪唑并哌嗪的作用机制

Elizabeth Winzeler, Krypton Carolino, Mariana Laureano De Souza, Daisy Chen, Jean-Claude Farre, James Blauwkamp, Sabrina Absalon, Sonja Ghidelli-Disse, Alexander Morano, Jeffrey Dvorin, Maria Jose Lafuente-Monasterio, Francisco-Javier Gamo

1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis

1,3-二芳基吡唑酰基磺酰胺靶向结核分枝杆菌中的 HadAB/BC 复合物

Vinayak Singh, Anna E Grzegorzewicz, Stephen Fienberg, Rudolf Müller, Lutete Peguy Khonde, Olalla Sanz, Salvatore Alfonso, Beatriz Urones, Gerard Drewes, Marcus Bantscheff, Sonja Ghidelli-Disse, Thomas R Ioerger, Bhanupriya Angala, Jiuyu Liu, Richard E Lee, James C Sacchettini, Inna V Krieger, Mary

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation

SARS-CoV-2 驱动 JAK1/2 依赖性局部补体过度激活

Bingyu Yan # ,Tilo Freiwald # ,Daniel Chauss # ,Luopin Wang # ,Erin West # ,Carmen Mirabelli ,Charles J Zhang ,Eva-Maria Nichols ,Nazish Malik ,Richard Gregory ,Marcus Bantscheff ,Sonja Ghidelli-Disse ,Martin Kolev ,Tristan Frum ,Jason R Spence ,Jonathan Z Sexton ,Konstantinos D Alysandratos ,Darrell N Kotton ,Stefania Pittaluga ,Jack Bibby ,Nathalie Niyonzima ,Matthew R Olson ,Shahram Kordasti ,Didier Portilla ,Christiane E Wobus ,Arian Laurence ,Michail S Lionakis ,Claudia Kemper # ,Behdad Afzali # ,Majid Kazemian #

Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG

对疟原虫的出走和配子发生至关重要的 Ca2+ 信号依赖于与 PKG 相互作用的多通道膜蛋白

Aurélia C Balestra, Konstantinos Koussis, Natacha Klages, Steven A Howell, Helen R Flynn, Marcus Bantscheff, Carla Pasquarello, Abigail J Perrin, Lorenzo Brusini, Patrizia Arboit, Olalla Sanz, Laura Peces-Barba Castaño, Chrislaine Withers-Martinez, Alexandre Hainard, Sonja Ghidelli-Disse, Ambrosius

The multi-target aspect of an MmpL3 inhibitor: The BM212 series of compounds bind EthR2, a transcriptional regulator of ethionamide activation

MmpL3 抑制剂的多靶点方面:BM212 系列化合物与 EthR2(乙硫异烟胺激活的转录调节剂)结合

Alice R Moorey, Alejandro Cabanillas, Sarah M Batt, Sonja Ghidelli-Disse, Beatriz Urones, Olalla Sanz, Joel Lelievre, Marcus Bantscheff, Liam R Cox, Gurdyal S Besra

Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity

抑制耐药性恶性疟原虫激酶PKG可发挥预防、血液阶段和阻断传播的抗疟原虫活性

Manu Vanaerschot, James M Murithi, Charisse Flerida A Pasaje, Sonja Ghidelli-Disse, Louis Dwomoh, Megan Bird, Natasha Spottiswoode, Nimisha Mittal, Lauren B Arendse, Edward S Owen, Kathryn J Wicht, Giulia Siciliano, Markus Bösche, Tomas Yeo, T R Santha Kumar, Sachel Mok, Emma F Carpenter, Marla J Gi

Loss of N-Glycanase 1 Alters Transcriptional and Translational Regulation in K562 Cell Lines

N-聚糖酶 1 的缺失会改变 K562 细胞系中的转录和翻译调控

William F Mueller, Petra Jakob, Han Sun, Sandra Clauder-Münster, Sonja Ghidelli-Disse, Diana Ordonez, Markus Boesche, Marcus Bantscheff, Paul Collier, Bettina Haase, Vladimir Benes, Malte Paulsen, Peter Sehr, Joe Lewis, Gerard Drewes, Lars M Steinmetz