日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Alzheimer's Disease Pathogenic Mechanisms: Linking Redox Homeostasis and Mitochondria-Associated Metabolic Pathways Through Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2)

阿尔茨海默病致病机制:通过核因子E2相关因子2 (Nrf2) 连接氧化还原稳态和线粒体相关代谢途径

Rostagno, Agueda; Ghiso, Jorge

Antioxidants Trolox and Methazolamide Protect Microvascular Endothelial Cells from Oxidative Damage Induced by Sporadic and Familial Forms of Oligomeric Amyloid-β.

抗氧化剂 Trolox 和甲唑胺可保护微血管内皮细胞免受散发性和家族性寡聚淀粉样蛋白-β 引起的氧化损伤。

Valle Maria Luisa, Getaneh Bitseat, William Christopher, Ghiso Jorge, Rostagno Agueda

Functionally distinct pericyte subsets differently regulate amyloid-β deposition in patients with Alzheimer's disease

功能不同的周细胞亚群对阿尔茨海默病患者的β-淀粉样蛋白沉积具有不同的调控作用

Bohannon, Diana G; Long, Danielle; Okhravi, Hamid R; Lee, Sunhee C; De Jesus, Christopher Lawrence; Neubert, Thomas A; Rostagno, Agueda A; Ghiso, Jorge A; Kim, Woong-Ki

Protocol for culture, purification, and target validation of a hybridoma-generated monoclonal antibody targeting Aβ truncated species.

针对 Aβ 截短物种的杂交瘤产生的单克隆抗体的培养、纯化和靶向验证方案

Valle Maria Luisa, Getaneh Bitseat, Loveland James, Erdjument-Bromage Hediye, William Christopher, Neubert Thomas A, Rostagno Agueda, Ghiso Jorge

Identification of isoAsp7-Aβ as a major Aβ variant in Alzheimer's disease, dementia with Lewy bodies and vascular dementia

鉴定出isoAsp7-Aβ是阿尔茨海默病、路易体痴呆和血管性痴呆中的主要Aβ变体

Schrempel, Sarah; Kottwitz, Anna Katharina; Piechotta, Anke; Gnoth, Kathrin; Büschgens, Luca; Hartlage-Rübsamen, Maike; Morawski, Markus; Schenk, Mathias; Kleinschmidt, Martin; Serrano, Geidy E; Beach, Thomas G; Rostagno, Agueda; Ghiso, Jorge; Heneka, Michael T; Walter, Jochen; Wirths, Oliver; Schilling, Stephan; Roßner, Steffen

N-terminally truncated Aβ4-x proteoforms and their relevance for Alzheimer's pathophysiology

N端截短的Aβ4-x蛋白异构体及其与阿尔茨海默病病理生理学的相关性

Rostagno, Agueda; Cabrera, Erwin; Lashley, Tammaryn; Ghiso, Jorge

Identification of Clusterin as a Major ABri- and ADan-Binding Protein Using Affinity Chromatography

利用亲和层析法鉴定簇蛋白为主要的ABri和ADan结合蛋白

Rostagno, Agueda; Calero, Miguel; Ghiso, Jorge

Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

更正:21三体综合征脑类器官中患者特异性的阿尔茨海默病样病理揭示BACE2是人脑中一种剂量敏感的阿尔茨海默病抑制基因

Alić, Ivan; Goh, Pollyanna A; Murray, Aoife; Portelius, Erik; Gkanatsiou, Eleni; Gough, Gillian; Mok, Kin Y; Koschut, David; Brunmeir, Reinhard; Yeap, Yee Jie; O'Brien, Niamh L; Groet, Jürgen; Shao, Xiaowei; Havlicek, Steven; Dunn, N Ray; Kvartsberg, Hlin; Brinkmalm, Gunnar; Hithersay, Rosalyn; Startin, Carla; Hamburg, Sarah; Phillips, Margaret; Pervushin, Konstantin; Turmaine, Mark; Wallon, David; Rovelet-Lecrux, Anne; Soininen, Hilkka; Volpi, Emanuela; Martin, Joanne E; Foo, Jia Nee; Becker, David L; Rostagno, Agueda; Ghiso, Jorge; Krsnik, Željka; Šimić, Goran; Kostović, Ivica; Mitrečić, Dinko; Francis, Paul T; Blennow, Kaj; Strydom, Andre; Hardy, John; Zetterberg, Henrik; Nižetić, Dean

Association of clusterin with the BRI2-derived amyloid molecules ABri and ADan

簇蛋白与 BRI2 衍生的淀粉样蛋白分子 ABri 和 ADan 的关联

Rostagno, Agueda; Calero, Miguel; Holton, Janice L; Revesz, Tamas; Lashley, Tammaryn; Ghiso, Jorge

Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage

Nrf2 通过 PI3K/GSK-3 通路激活,从而保护神经元细胞免受 Aβ 介导的氧化和代谢损伤。

Sotolongo, Krystal; Ghiso, Jorge; Rostagno, Agueda