日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Sex-based multiomics analysis uncovers metabolic and molecular mediators linking MASH and atherosclerosis

基于性别的多组学分析揭示了MASH与动脉粥样硬化之间的代谢和分子介质

Das, Sandeep; Anand, Sumit Kumar; McKinney, M Peyton; Richard, Koral S E; Mahmud, Iqbal; Rohilla, Sumati; Arias, Fabio; Ghrayeb, Alia; Wei, Bo; Tan, Lin; Liu, Zhipeng; Kumar, Dhananjay; Finney, Alexandra C; Pandey, Nilesh; Kaur, Harpreet; Pandit, Rajan; Zhang, Xiaolu; Ben Dhaou, Cyrine; Thayer, Sarah P; Razani, Babak; Cai, Bishuang; Chang, Fei; Schopfer, Francisco J; Liu, Wanqing; Fisher, Edward A; Radhakrishnan, Sridhar; Gottlieb, Eyal; Orr, A Wayne; Dhanesha, Nirav; Yurdagul, Arif Jr; Lorenzi, Philip L; Rom, Oren

Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD.

在 MASLD 中,SHMT2 活性逆转导致丝氨酸合成,进而引起甘氨酸耗竭和对乙酰氨基酚肝毒性

Ghrayeb Alia, Finney Alexandra C, Agranovich Bella, Peled Daniel, Anand Sumit Kumar, McKinney M Peyton, Sarji Mahasen, Yang Dongshan, Weissman Natan, Drucker Shani, Fernandes Sara Isabel, Fernández-García Jonatan, Mahan Kyle, Abassi Zaid, Tan Lin, Lorenzi Philip L, Traylor James, Zhang Jifeng, Abramovich Ifat, Chen Y Eugene, Rom Oren, Mor Inbal, Gottlieb Eyal

Fatty liver-mediated glycine restriction impairs glutathione synthesis and causes hypersensitization to acetaminophen

脂肪肝介导的甘氨酸限制会损害谷胱甘肽的合成,并导致对对乙酰氨基酚的过敏反应。

Ghrayeb, Alia; Agranovich, Bella; Peled, Daniel; Finney, Alexandra C; Abramovich, Ifat; Garcia, Jonatan Fernandez; Traylor, James; Drucker, Shani; Fernandes, Sara Isabelle; Weissman, Natan; Chen, Y Eugene; Rom, Oren; Mor, Inbal; Gottlieb, Eyal

Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome

基于甘氨酸的治疗通过调节脂肪酸氧化、谷胱甘肽合成和肠道微生物群来改善非酒精性脂肪性肝病。

Rom, Oren; Liu, Yuhao; Liu, Zhipeng; Zhao, Ying; Wu, Jianfeng; Ghrayeb, Alia; Villacorta, Luis; Fan, Yanbo; Chang, Lin; Wang, Lu; Liu, Cai; Yang, Dongshan; Song, Jun; Rech, Jason C; Guo, Yanhong; Wang, Huilun; Zhao, Guizhen; Liang, Wenying; Koike, Yui; Lu, Haocheng; Koike, Tomonari; Hayek, Tony; Pennathur, Subramaniam; Xi, Chuanwu; Wen, Bo; Sun, Duxin; Garcia-Barrio, Minerva T; Aviram, Michael; Gottlieb, Eyal; Mor, Inbal; Liu, Wanqing; Zhang, Jifeng; Chen, Y Eugene