A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3
一种新型的apoE模拟物可提高表达APOE3的雄性小鼠脑内apoE水平,减少Aβ病理,并在病理发生前进行治疗以改善记忆力。
期刊:Alzheimers Research & Therapy
影响因子:
doi:10.1186/s13195-023-01353-z
Valencia-Olvera, Ana C; Balu, Deebika; Bellur, Shreya; McNally, Thomas; Saleh, Yaseen; Pham, Don; Ghura, Shivesh; York, Jason; Johansson, Jan O; LaDu, Mary Jo; Tai, Leon