CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons
CDKL5 通过增强突触后隔室中的 NGL-1-PSD95 相互作用来确保兴奋性突触的稳定性,而在患者 iPSC 衍生的神经元中,CDKL5 受到损害
期刊:Nature Cell Biology
影响因子:17.3
doi:10.1038/ncb2566
Sara Ricciardi, Federica Ungaro, Melanie Hambrock, Nils Rademacher, Gilda Stefanelli, Dario Brambilla, Alessandro Sessa, Cinzia Magagnotti, Angela Bachi, Elisa Giarda, Chiara Verpelli, Charlotte Kilstrup-Nielsen, Carlo Sala, Vera M Kalscheuer, Vania Broccoli