日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Validation of Clinical-Grade Electroporation Systems for CRISPR-Cas9-Mediated Gene Therapy in Primary Hepatocytes for the Correction of Inherited Metabolic Liver Disease.

验证用于 CRISPR-Cas9 介导的基因治疗在原代肝细胞中治疗遗传性代谢性肝病的临床级电穿孔系统

Gibson Justin, Dhungana Abishek, Pokhrel Menam, Arthur Benjamin, Suresh Pramita, Adebayo Olumide, Cottle Renee N

One Shock, Not One Cure: Electroporation Reveals Disease-Specific Constraints in Hepatocyte Gene Editing Therapy.

一次电击,而非一次治愈:电穿孔揭示肝细胞基因编辑疗法中疾病特异性限制

Clark Callie, Pokhrel Menam, Arthur Benjamin, Suresh Pramita, Ates Ilayda, Gibson Justin, Dhungana Abishek, Mehlem Ryan, Boysia Andrew, Padalkar Mugdha V, Pokhrel Achala, Echesabal-Chen Jing, Vonada Anne, Stamatikos Alexis, Savinova Olga V, Grompe Markus, Cottle Renee N

Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire

免疫球蛋白重链基因座的遗传变异决定了人类抗体库

Oscar L Rodriguez, Yana Safonova, Catherine A Silver, Kaitlyn Shields, William S Gibson, Justin T Kos, David Tieri, Hanzhong Ke, Katherine J L Jackson, Scott D Boyd, Melissa L Smith, Wayne A Marasco, Corey T Watson0

Diet-Induced Obesity Impairs Outcomes and Induces Multi-Factorial Deficiencies in Effector T Cell Responses Following Anti-CTLA-4 Combinatorial Immunotherapy in Renal Tumor-Bearing Mice

饮食诱导的肥胖会损害肾肿瘤小鼠接受抗CTLA-4联合免疫疗法后的疗效,并导致效应T细胞反应的多因素缺陷

Turbitt, William J; Boi, Shannon K; Gibson, Justin T; Orlandella, Rachael M; Norian, Lyse A

Obesity diminishes response to PD-1-based immunotherapies in renal cancer

肥胖会降低肾癌患者对基于PD-1的免疫疗法的反应。

Boi, Shannon K; Orlandella, Rachael M; Gibson, Justin Tyler; Turbitt, William James; Wald, Gal; Thomas, Lewis; Buchta Rosean, Claire; Norris, Katlyn E; Bing, Megan; Bertrand, Laura; Gross, Brett P; Makkouk, Amani; Starenki, Dmytro; Farag, Kristine I; Sorge, Robert E; Brown, James A; Gordetsky, Jennifer; Yasin, Hesham; Garje, Rohan; Nandagopal, Lakshminarayanan; Weiner, George J; Lubaroff, David M; Arend, Rebecca C; Li, Peng; Zakharia, Yousef; Yang, Eddy; Salem, Aliasger K; Nepple, Kenneth; Marquez-Lago, Tatiana T; Norian, Lyse A

Obesity-Associated Myeloid-Derived Suppressor Cells Promote Apoptosis of Tumor-Infiltrating CD8 T Cells and Immunotherapy Resistance in Breast Cancer

肥胖相关的髓系来源抑制细胞促进肿瘤浸润CD8 T细胞凋亡和乳腺癌免疫治疗耐药性

Gibson, Justin T; Orlandella, Rachael M; Turbitt, William J; Behring, Michael; Manne, Upender; Sorge, Robert E; Norian, Lyse A

Randomized trial of weight loss in primary breast cancer: Impact on body composition, circulating biomarkers and tumor characteristics

一项关于原发性乳腺癌患者减重的随机试验:对身体成分、循环生物标志物和肿瘤特征的影响

Demark-Wahnefried, Wendy; Rogers, Laura Q; Gibson, Justin T; Harada, Shuko; Frugé, Andrew D; Oster, Robert A; Grizzle, William E; Norian, Lyse A; Yang, Eddy S; Della Manna, Deborah; Jones, Lee W; Azrad, Maria; Krontiras, Helen

Obesity induces limited changes to systemic and local immune profiles in treatment-naive human clear cell renal cell carcinoma

肥胖对未经治疗的人类透明细胞肾细胞癌的全身和局部免疫谱的影响有限。

Gibson, Justin T; Norris, Katlyn E; Wald, Gal; Buchta Rosean, Claire M; Thomas, Lewis J; Boi, Shannon K; Bertrand, Laura A; Bing, Megan; Gordetsky, Jennifer B; Deshane, Jessy; Li, Peng; Brown, James A; Nepple, Kenneth G; Norian, Lyse A

Therapeutic Time-restricted Feeding Reduces Renal Tumor Bioluminescence in Mice but Fails to Improve Anti-CTLA-4 Efficacy

限时治疗性喂食可降低小鼠肾肿瘤生物发光,但未能提高抗CTLA-4疗效

Turbitt, William J; Orlandella, Rachael M; Gibson, Justin T; Peterson, Courtney M; Norian, Lyse A

Mutations in the S-Adenosylmethionine Synthetase Genes SAM1 and SAM2 Differentially Affect Genome Stability in Saccharomyces cerevisiae

酿酒酵母中S-腺苷甲硫氨酸合成酶基因SAM1和SAM2的突变对基因组稳定性的影响不同

Hoffert, Kellyn M; Higginbotham, Kathryn S P; Gibson, Justin T; Oehrle, Stuart; Strome, Erin D