日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma

在多发性骨髓瘤临床前模型中鉴定出具有强效体内外活性的 CARM1 抑制剂

Allison E Drew, Oscar Moradei, Suzanne L Jacques, Nathalie Rioux, Ann P Boriack-Sjodin, Christina Allain, Margaret Porter Scott, Lei Jin, Alejandra Raimondi, Jessica L Handler, Heidi M Ott, Ryan G Kruger, Michael T McCabe, Christopher Sneeringer, Thomas Riera, Gideon Shapiro, Nigel J Waters, Lorna H

Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator

胆甾烯酸是一种内源性胆固醇代谢物,是一种有效的 γ-分泌酶调节剂

Joo In Jung, Ashleigh R Price, Thomas B Ladd, Yong Ran, Hyo-Jin Park, Carolina Ceballos-Diaz, Lisa A Smithson, Günther Hochhaus, Yufei Tang, Rajender Akula, Saritha Ba, Edward H Koo, Gideon Shapiro, Kevin M Felsenstein, Todd E Golde

Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment

神经元库操纵的钙离子进入途径作为亨廷顿氏病治疗的新靶点

Jun Wu, Hsin-Pei Shih, Vladimir Vigont, Lori Hrdlicka, Len Diggins, Carol Singh, Matt Mahoney, Richard Chesworth, Gideon Shapiro, Olga Zimina, Xuesong Chen, Qingqing Wu, Lyubov Glushankova, Michael Ahlijanian, Gerhard Koenig, Galina N Mozhayeva, Elena Kaznacheyeva, Ilya Bezprozvanny