日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

脂化ApoE与受体相互作用的减少可保护机体免受溶酶体中ApoE及其脂质货物致病性的侵害。

Jing L Guo,Dylan Braun,Gabriel A Fitzgerald,Yun-Ting Hsieh,Lionel Rougé,Alexandra Litvinchuk,Micah Steffek,Nicholas E Propson,Catherine M Heffner,Claire Discenza,Suk Ji Han,Anil Rana,Lukas L Skuja,Bi Qi Lin,Elizabeth W Sun,Sonnet S Davis,Srijana Balasundar,Isabel Becerra,Jason C Dugas,Connie Ha,Jennifer Hsiao-Nakamoto,Fen Huang,Shourya Jain,Jennifer E Kung,Nicholas P D Liau,Cathal S Mahon,Hoang N Nguyen,Nathan Nguyen,Madhuja Samaddar,Yajuan Shi,David Tatarakis,Yuxi Tian,Yuda Zhu,Jung H Suh,Thomas Sandmann,Meredith E K Calvert,Annie Arguello,Lesley A Kane,Joseph W Lewcock,David M Holtzman,Christopher M Koth,Gilbert Di Paolo

LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome

LRRK2激酶活性调节溶酶体中与帕金森病相关的脂质

Michael T Maloney # ,Xiang Wang # ,Rajarshi Ghosh ,Shan V Andrews ,Romeo Maciuca ,Shababa T Masoud ,Maayan Agam ,Richard M Caprioli ,Giuseppe Astarita ,Vitaliy V Bondar ,John Chen ,Chi-Lu Chiu ,Sonnet S Davis ,Audrey Cheuk-Nga Ho ,Hoang N Nguyen ,Nicholas E Propson ,Michelle L Reyzer ,Oliver B Davis ,Matthew C Deen ,Sha Zhu ,Gilbert Di Paolo ,David J Vocadlo ,Anthony A Estrada ,Javier de Vicente ,Joseph W Lewcock ,Annie Arguello ,Jung H Suh ,Sarah Huntwork-Rodriguez ,Anastasia G Henry

Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

在随机临床试验中,研究性 eIF2B 激活剂 DNL343 可调节 TDP-43 病理临床前模型和 ALS 患者的整合应激反应。

Brittany N Flores # ,Seungyoon B Yu # ,Isaac V Cohen # ,Melania H Fanok # ,Wei Luan ,Romeo D Maciuca ,Linus D Sun ,Richard M Tsai ,Maurits Vissers ,Lars Smits ,Tommy M Bunte ,Anna Bakardjiev ,Srijana Balasundar ,Meredith E K Calvert ,Marcus Y Chin ,Sarah K Dobbins ,William E Dowdle ,Meng Fang ,Jules A A C Heuberger ,Connie L Ha ,Fen Huang ,Takashi Miyamoto ,Maksim Osipov ,Lidia Madrid San Martin ,Katie Saund ,David Tatarakis ,Anthony Q Vu ,Chenling Xiong ,Gene W Yeo ,Geert Jan Groeneveld ,Leonard H van den Berg ,Shyeilla Dhuria ,Anthony A Estrada ,Danna Jennings ,Thomas Sandmann ,Carole Ho ,Kimberly Scearce-Levie ,Ernie Yulyaningsih ,Adam K Walker ,Gilbert Di Paolo ,Lesley A Kane ,Matthew D Troyer ,Joseph W Lewcock

Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist

LXR激动剂可改善Tau蛋白和ApoE4相关的胶质细胞脂质积累和神经退行性变

Alexandra Litvinchuk ,Jung H Suh ,Jing L Guo ,Karin Lin ,Sonnet S Davis ,Nga Bien-Ly ,Eric Tycksen ,G Travis Tabor ,Javier Remolina Serrano ,Melissa Manis ,Xin Bao ,Choonghee Lee ,Megan Bosch ,Enmanuel J Perez ,Carla M Yuede ,Anil G Cashikar ,Jason D Ulrich ,Gilbert Di Paolo ,David M Holtzman

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference

APOE基因与痴呆症研究进展:2023年AAIC进展:APOE会议亮点

Kloske, Courtney M; Belloy, Michael E; Blue, Elizabeth E; Bowman, Gregory R; Carrillo, Maria C; Chen, Xiaoying; Chiba-Falek, Ornit; Davis, Albert A; Paolo, Gilbert Di; Garretti, Francesca; Gate, David; Golden, Lesley R; Heinecke, Jay W; Herz, Joachim; Huang, Yadong; Iadecola, Costantino; Johnson, Lance A; Kanekiyo, Takahisa; Karch, Celeste M; Khvorova, Anastasia; Koppes-den Hertog, Sascha J; Lamb, Bruce T; Lawler, Paige E; Guen, Yann Le; Litvinchuk, Alexandra; Liu, Chia-Chen; Mahinrad, Simin; Marcora, Edoardo; Marino, Claudia; Michaelson, Danny M; Miller, Justin J; Morganti, Josh M; Narayan, Priyanka S; Naslavsky, Michel S; Oosthoek, Marlies; Ramachandran, Kapil V; Ramakrishnan, Abhirami; Raulin, Ana-Caroline; Robert, Aiko; Saleh, Rasha N M; Sexton, Claire; Shah, Nilomi; Shue, Francis; Sible, Isabel J; Soranno, Andrea; Strickland, Michael R; Tcw, Julia; Thierry, Manon; Tsai, Li-Huei; Tuckey, Ryan A; Ulrich, Jason D; van der Kant, Rik; Wang, Na; Wellington, Cheryl L; Weninger, Stacie C; Yassine, Hussein N; Zhao, Na; Bu, Guojun; Goate, Alison M; Holtzman, David M

Lysosomal defects in Grn loss of function modulate microglial cell state and immune responses

Grn功能缺失导致的溶酶体缺陷会调节小胶质细胞状态和免疫反应。

Xu, Jingyi; Li, Yue; Yang, Xi; Li, Hong; Xiao, Xi; You, Jia; Li, Huawei; Zheng, Lingnan; Yi, Cheng; Li, Zhaojun; Huang, Ying; Pandey, Arvind; Hambarde, Shashank; Baskin, David; Helekar, Santosh; Mukherji, Devarshi; Haase, Santiago; Varela, Maria Luisa; Welch, Joshua; Lowenstein, Pedro; Castro, Maria; Guo, Xiaopeng; Chang, Mengqi; Huang, Yongsheng; Zhang, Fan; Zhao, Yuanli; Xing, Bing; Tejwani, Leon; Paolo, Gilbert Di

A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models

一种带有血脑屏障转运载体的TREM2激活抗体可增强阿尔茨海默病模型中的小胶质细胞代谢。

Bettina van Lengerich # ,Lihong Zhan # ,Dan Xia # ,Darren Chan ,David Joy ,Joshua I Park ,David Tatarakis ,Meredith Calvert ,Selina Hummel ,Steve Lianoglou ,Michelle E Pizzo ,Rachel Prorok ,Elliot Thomsen ,Laura M Bartos ,Philipp Beumers ,Anja Capell ,Sonnet S Davis ,Lis de Weerd ,Jason C Dugas ,Joseph Duque ,Timothy Earr ,Kapil Gadkar ,Tina Giese ,Audrey Gill ,Johannes Gnörich ,Connie Ha ,Malavika Kannuswamy ,Do Jin Kim ,Sebastian T Kunte ,Lea H Kunze ,Diana Lac ,Kendra Lechtenberg ,Amy Wing-Sze Leung ,Chun-Chi Liang ,Isabel Lopez ,Paul McQuade ,Anuja Modi ,Vanessa O Torres ,Hoang N Nguyen ,Ida Pesämaa ,Nicholas Propson ,Marvin Reich ,Yaneth Robles-Colmenares ,Kai Schlepckow ,Luna Slemann ,Hilda Solanoy ,Jung H Suh ,Robert G Thorne ,Chandler Vieira ,Karin Wind-Mark ,Ken Xiong ,Y Joy Yu Zuchero ,Dolo Diaz ,Mark S Dennis ,Fen Huang ,Kimberly Scearce-Levie ,Ryan J Watts ,Christian Haass ,Joseph W Lewcock ,Gilbert Di Paolo ,Matthias Brendel ,Pascal E Sanchez ,Kathryn M Monroe

Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes

Rab12是LRRK2的调节因子,其激活受受损溶酶体的影响。

Xiang Wang #,Vitaliy V Bondar #,Oliver B Davis,Michael T Maloney,Maayan Agam,Marcus Y Chin,Audrey Cheuk-Nga Ho,Rajarshi Ghosh,Dara E Leto,David Joy,Meredith E K Calvert,Joseph W Lewcock,Gilbert Di Paolo,Robert G Thorne,Zachary K Sweeney,Anastasia G Henry

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

新型应用程序敲入小鼠模型展现了淀粉样蛋白病理的关键特征,并揭示了小胶质细胞严重的代谢紊乱。

Dan Xia # ,Steve Lianoglou # ,Thomas Sandmann ,Meredith Calvert ,Jung H Suh ,Elliot Thomsen ,Jason Dugas ,Michelle E Pizzo ,Sarah L DeVos ,Timothy K Earr ,Chia-Ching Lin ,Sonnet Davis ,Connie Ha ,Amy Wing-Sze Leung ,Hoang Nguyen ,Roni Chau ,Ernie Yulyaningsih ,Isabel Lopez ,Hilda Solanoy ,Shababa T Masoud ,Chun-Chi Liang ,Karin Lin ,Giuseppe Astarita ,Nathalie Khoury ,Joy Yu Zuchero ,Robert G Thorne ,Kevin Shen ,Stephanie Miller ,Jorge J Palop ,Dylan Garceau ,Michael Sasner ,Jennifer D Whitesell ,Julie A Harris ,Selina Hummel ,Johannes Gnörich ,Karin Wind ,Lea Kunze ,Artem Zatcepin ,Matthias Brendel ,Michael Willem ,Christian Haass ,Daniel Barnett ,Till S Zimmer ,Anna G Orr ,Kimberly Scearce-Levie ,Joseph W Lewcock ,Gilbert Di Paolo ,Pascal E Sanchez

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency

TREM2 的缺失可以挽救小胶质细胞的过度激活,但不能挽救前粒蛋白缺乏模型中的溶酶体功能障碍和神经毒性。

Anika Reifschneider ,Sophie Robinson ,Bettina van Lengerich ,Johannes Gnörich ,Todd Logan ,Steffanie Heindl ,Miriam A Vogt ,Endy Weidinger ,Lina Riedl ,Karin Wind ,Artem Zatcepin ,Ida Pesämaa ,Sophie Haberl ,Brigitte Nuscher ,Gernot Kleinberger ,Julien Klimmt ,Julia K Götzl ,Arthur Liesz ,Katharina Bürger ,Matthias Brendel ,Johannes Levin ,Janine Diehl-Schmid ,Jung Suh ,Gilbert Di Paolo ,Joseph W Lewcock ,Kathryn M Monroe ,Dominik Paquet ,Anja Capell ,Christian Haass