日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting tauopathy with engineered tau-degrading intrabodies

利用工程化的 tau 降解胞内抗体治疗 tau 病

Gilbert Gallardo, Connie H Wong, Sara M Ricardez, Carolyn N Mann, Kent H Lin, Cheryl E G Leyns, Hong Jiang, David M Holtzman

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

利用抗体靶向非脂化的聚集载脂蛋白 E 可抑制淀粉样蛋白的积累

Fan Liao, Aimin Li, Monica Xiong, Nga Bien-Ly, Hong Jiang, Yin Zhang, Mary Beth Finn, Rosa Hoyle, Jennifer Keyser, Katheryn B Lefton, Grace O Robinson, Javier Remolina Serrano, Adam P Silverman, Jing L Guo, Jennifer Getz, Kirk Henne, Cheryl Eg Leyns, Gilbert Gallardo, Jason D Ulrich, Patrick M Sulli

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

ApoE4 显著加剧了 tau 病小鼠模型中 tau 介导的神经退行性病变

Yang Shi, Kaoru Yamada, Shane Antony Liddelow, Scott T Smith, Lingzhi Zhao, Wenjie Luo, Richard M Tsai, Salvatore Spina, Lea T Grinberg, Julio C Rojas, Gilbert Gallardo, Kairuo Wang, Joseph Roh, Grace Robinson, Mary Beth Finn, Hong Jiang, Patrick M Sullivan, Caroline Baufeld, Michael W Wood, Courtne

AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy

AAV 介导的抗 tau scFv 表达可减少 tau 病小鼠模型中的 tau 积累

Christina Ising, Gilbert Gallardo, Cheryl E G Leyns, Connie H Wong, Hong Jiang, Floy Stewart, Lauren J Koscal, Joseph Roh, Grace O Robinson, Javier Remolina Serrano, David M Holtzman

Ubiquitin-Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in Mice

泛素-突触小泡融合蛋白导致小鼠突触前运动末梢退化

Yun Liu, Hongqiao Li, Yoshie Sugiura, Weiping Han, Gilbert Gallardo, Mikhail Khvotchev, Yinan Zhang, Ege T Kavalali, Thomas C Südhof, Weichun Lin