日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy

对人类短尾蛋白DNA识别的结构性见解以及用于癌症治疗的新型结合剂的发现

Newman, Joseph A; Gavard, Angeline E; Imprachim, Nergis; Aitkenhead, Hazel; Sheppard, Hadley E; Te Poele, Robert; Clarke, Paul A; Hossain, Mohammad Anwar; Temme, Louisa; Oh, Hans J; Wells, Carrow I; Davis-Gilbert, Zachary W; Workman, Paul; Gileadi, Opher; Drewry, David H

Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models

IFNγ对免疫微环境的重塑可抵消小鼠肿瘤模型中IFNγ依赖的肿瘤逃逸。

Vivian W C Lau ,Gracie J Mead ,Zofia Varyova ,Julie M Mazet ,Anagha Krishnan ,Edward W Roberts ,Gennaro Prota ,Uzi Gileadi ,Kim S Midwood ,Vincenzo Cerundolo ,Audrey Gérard

Gluebodies Offer a Route To Improve Crystal Reliability and Diversity through Transferable Nanobody Mutations That Introduce Constitutive Close Contacts

胶体提供了一种通过可转移的纳米抗体突变来提高晶体可靠性和多样性的途径,这些突变引入了组成性的紧密接触。

Ye, Mingda; Makola, Mpho; Richards, Mark W; Newman, Joseph A; Fairhead, Michael; Burgess, Selena G; Wu, Zhihuang; Maclean, Elizabeth; Wright, Nathan D; Koekemoer, Lizbé; Thompson, Andrew; Bezerra, Gustavo Arruda; Yi, Gangshun; Li, Huanyu; Rangel, Victor L; Mamalis, Dimitrios; Aitkenhead, Hazel; Davis, Benjamin G; Gilbert, Robert J C; Duerr, Katharina L; Bayliss, Richard; Gileadi, Opher; von Delft, Frank

Regional Expression of Dystrophin Gene Transcripts and Proteins in the Mouse Brain.

小鼠脑内肌营养不良蛋白基因转录本和蛋白质的区域表达。

Tetorou Konstantina, Aghaeipour Artadokht, Ma Shunyi, Gileadi Talia, Saoudi Amel, Perdomo Quinteiro Pablo, Aragón Jorge, van Putten Maaike, Spitali Pietro, Montanez Cecilia, Vaillend Cyrille, Morgan Jennifer E, Montanaro Federica, Muntoni Francesco

Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity

非常规的人类CD61与CD103配对可促进TCR信号传导和抗原特异性T细胞细胞毒性

Megat H B A Hamid # ,Pablo F Cespedes # ,Chen Jin # ,Ji-Li Chen # ,Uzi Gileadi # ,Elie Antoun # ,Zhu Liang # ,Fei Gao ,Renuka Teague ,Nikita Manoharan ,David Maldonado-Perez ,Nasullah Khalid-Alham ,Lucia Cerundolo ,Raul Ciaoca ,Svenja S Hester ,Adán Pinto-Fernández ,Simeon D Draganov ,Iolanda Vendrell ,Guihai Liu ,Xuan Yao ,Audun Kvalvaag ,Delaney C C Dominey-Foy ,Charunya Nanayakkara ,Nikolaos Kanellakis ,Yi-Ling Chen ,Craig Waugh ,Sally-Ann Clark ,Kevin Clark ,Paul Sopp ,Najib M Rahman ,Clare Verrill ,Benedikt M Kessler ,Graham Ogg ,Ricardo A Fernandes ,Roman Fisher ,Yanchun Peng ,Michael L Dustin ,Tao Dong

Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases.

抗体激动剂通过局部排除受体型蛋白酪氨酸磷酸酶来触发免疫受体信号传导。

Lippert Anna H, Paluch Christopher, Gaglioni Meike, Vuong Mai T, McColl James, Jenkins Edward, Fellermeyer Martin, Clarke Joseph, Sharma Sumana, Moreira da Silva Sara, Akkaya Billur, Anzilotti Consuelo, Morgan Sara H, Jessup Claire F, Körbel Markus, Gileadi Uzi, Leitner Judith, Knox Rachel, Chirifu Mami, Huo Jiandong, Yu Susan, Ashman Nicole, Lui Yuan, Wilkinson Ian, Attfield Kathrine E, Fugger Lars, Robertson Nathan J, Lynch Christopher J, Murray Lynne, Steinberger Peter, Santos Ana Mafalda, Lee Steven F, Cornall Richard J, Klenerman David, Davis Simon J

Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8(+) T cells

出版商更正:信号素3A通过诱导肿瘤特异性CD8(+) T细胞的细胞骨架麻痹而导致免疫抑制。

Barnkob, Mike B; Michaels, Yale S; André, Violaine; Macklin, Philip S; Gileadi, Uzi; Valvo, Salvatore; Rei, Margarida; Kulicke, Corinna; Chen, Ji-Li; Jain, Vitul; Woodcock, Victoria K; Colin-York, Huw; Hadjinicolaou, Andreas V; Kong, Youxin; Mayya, Viveka; Mazet, Julie M; Mead, Gracie-Jennah; Bull, Joshua A; Rijal, Pramila; Pugh, Christopher W; Townsend, Alain R; Gérard, Audrey; Olsen, Lars R; Fritzsche, Marco; Fulga, Tudor A; Dustin, Michael L; Jones, E Yvonne; Cerundolo, Vincenzo

Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

塞马福林3A通过诱导肿瘤特异性CD8+ T细胞的细胞骨架麻痹而导致免疫抑制。

Mike B Barnkob ,Yale S Michaels ,Violaine André ,Philip S Macklin ,Uzi Gileadi ,Salvatore Valvo ,Margarida Rei ,Corinna Kulicke ,Ji-Li Chen ,Vitul Jain ,Victoria K Woodcock ,Huw Colin-York ,Andreas V Hadjinicolaou ,Youxin Kong ,Viveka Mayya ,Julie M Mazet ,Gracie-Jennah Mead ,Joshua A Bull ,Pramila Rijal ,Christopher W Pugh ,Alain R Townsend ,Audrey Gérard ,Lars R Olsen ,Marco Fritzsche ,Tudor A Fulga ,Michael L Dustin ,E Yvonne Jones ,Vincenzo Cerundolo

Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target

具有细胞活性的小分子抑制剂证实了SNM1A DNA修复核酸酶作为癌症靶点的价值。

Bielinski, Marcin; Henderson, Lucy R; Yosaatmadja, Yuliana; Swift, Lonnie P; Baddock, Hannah T; Bowen, Matthew J; Brem, Jürgen; Jones, Philip S; McElroy, Stuart P; Morrison, Angus; Speake, Michael; van Boeckel, Stan; van Doornmalen, Els; van Groningen, Jan; van den Hurk, Helma; Gileadi, Opher; Newman, Joseph A; McHugh, Peter J; Schofield, Christopher J

Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε

新型二氢蝶啶酮衍生物作为未充分研究的人类激酶痘苗相关激酶 1 和酪蛋白激酶 1δ/ε 的有效抑制剂

Fernando H de Souza Gama, Luiz A Dutra, Michael Hawgood, Caio Vinícius Dos Reis, Ricardo A M Serafim, Marcos A Ferreira Jr, Bruno V M Teodoro, Jéssica Emi Takarada, André S Santiago, Dimitrios-Ilias Balourdas, Ann-Sofie Nilsson, Bruno Urien, Vitor M Almeida, Carina Gileadi, Priscila Z Ramos, Anita S