日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy

对人类短尾蛋白DNA识别的结构性见解以及用于癌症治疗的新型结合剂的发现

Newman, Joseph A; Gavard, Angeline E; Imprachim, Nergis; Aitkenhead, Hazel; Sheppard, Hadley E; Te Poele, Robert; Clarke, Paul A; Hossain, Mohammad Anwar; Temme, Louisa; Oh, Hans J; Wells, Carrow I; Davis-Gilbert, Zachary W; Workman, Paul; Gileadi, Opher; Drewry, David H

Gluebodies Offer a Route To Improve Crystal Reliability and Diversity through Transferable Nanobody Mutations That Introduce Constitutive Close Contacts

胶体提供了一种通过可转移的纳米抗体突变来提高晶体可靠性和多样性的途径,这些突变引入了组成性的紧密接触。

Ye, Mingda; Makola, Mpho; Richards, Mark W; Newman, Joseph A; Fairhead, Michael; Burgess, Selena G; Wu, Zhihuang; Maclean, Elizabeth; Wright, Nathan D; Koekemoer, Lizbé; Thompson, Andrew; Bezerra, Gustavo Arruda; Yi, Gangshun; Li, Huanyu; Rangel, Victor L; Mamalis, Dimitrios; Aitkenhead, Hazel; Davis, Benjamin G; Gilbert, Robert J C; Duerr, Katharina L; Bayliss, Richard; Gileadi, Opher; von Delft, Frank

Organocatalytic Switches of DNA Glycosylase OGG1 Catalyze a Highly Efficient AP-Lyase Function

DNA糖基化酶OGG1的有机催化开关可催化高效的AP裂解酶功能

Kehler, Mario; Zhou, Kaixin; Kemas, Aurino M; Del Prado, Alicia; Hutchinson, Emma Scaletti; Nairn, Elinor Hesslefors; Varga, Marek; Plattner, Yvonne; Zhong, Yi; Purewal-Sidhu, Oryn; Haslam, James; Wiita, Elisée; Gildie, Heather; Singerova, Karolina; Szaruga, Zuzanna; Almlöf, Ingrid; Hormann, Femke M; Liu, Kang-Cheng; Wallner, Olov; Ortis, Florian; Homan, Evert J; Gileadi, Opher; Rudd, Sean G; Stenmark, Pål; de Vega, Miguel; Helleday, Thomas; D'Arcy-Evans, Nicholas D; Lauschke, Volker M; Michel, Maurice

Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target

具有细胞活性的小分子抑制剂证实了SNM1A DNA修复核酸酶作为癌症靶点的价值。

Bielinski, Marcin; Henderson, Lucy R; Yosaatmadja, Yuliana; Swift, Lonnie P; Baddock, Hannah T; Bowen, Matthew J; Brem, Jürgen; Jones, Philip S; McElroy, Stuart P; Morrison, Angus; Speake, Michael; van Boeckel, Stan; van Doornmalen, Els; van Groningen, Jan; van den Hurk, Helma; Gileadi, Opher; Newman, Joseph A; McHugh, Peter J; Schofield, Christopher J

Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.

SHIP1 和 SHIP2 的 C2 结构域对肌醇 5-磷酸酶活性的调节

Bradshaw William J, Kennedy Emma C, Moreira Tiago, Smith Luke A, Chalk Rod, Katis Vittorio L, Benesch Justin L P, Brennan Paul E, Murphy Emma J, Gileadi Opher

The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures.

SYK激酶变构激活机制源于多个磷酸化ITAM结合结构

Bradshaw William J, Harris Gemma, Gileadi Opher, Katis Vittorio L

Development of a time-resolved fluorescence resonance energy transfer ultra-high throughput screening assay targeting SYK and FCER1G interaction.

开发一种针对 SYK 和 FCER1G 相互作用的时间分辨荧光共振能量转移超高通量筛选检测方法

Du Yuhong, Wang Dongxue, Katis Vittorio L, Zoeller Elizabeth L, Qui Min, Levey Allan I, Gileadi Opher, Fu Haian

Open drug discovery in Alzheimer's disease

阿尔茨海默病开放式药物研发

Axtman, Alison D; Brennan, Paul E; Frappier-Brinton, Tristan; Betarbet, Ranjita; Carter, Gregory W; Fu, Haian; Gileadi, Opher; Greenwood, Anna K; Leal, Karina; Longo, Frank M; Mangravite, Lara M; Edwards, Aled M; Levey, Allan I

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

对 Artemis 核酸内切酶的结构和机制的深入研究及其抑制策略

Yosaatmadja, Yuliana; Baddock, Hannah T; Newman, Joseph A; Bielinski, Marcin; Gavard, Angeline E; Mukhopadhyay, Shubhashish M M; Dannerfjord, Adam A; Schofield, Christopher J; McHugh, Peter J; Gileadi, Opher

RecQ helicases in DNA repair and cancer targets

RecQ解旋酶在DNA修复和癌症靶点中的作用

Newman, Joseph A; Gileadi, Opher