A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity
一种高发的狼疮风险单倍型会增加IRF7依赖的IFN-α诱导，从而增强抗病毒防御并加剧自身免疫。
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doi:10.64898/2026.01.21.26344474
Virolainen, Samuel J; Creighton, Kathryn; Dashtiahangar, Maryam; Krishnamurthy, Durga; Parks, Lois; Forney, Carmy; Ampadu, Britney; Rudrapatna, Akshata N; Dunn, Katelyn A; Parameswaran, Sreeja; Hesse, Hayley K; Chen, Xiaoting; VonHandorf, Andrew; Edsall, Lee E; Yin, Cailing; Lynch, Arthur; Gittens, Olivia E; Diouf, Arame A; Jones, Sydney H; Hass, Matthew; Javier, Ellen; Donmez, Omer A; Keddari, Yasine; Danzinger, Oded; Seelamneni, Harsha; Namjou-Khales, Bahram; Ainsworth, Hannah C; Comeau, Mary E; Marion, Miranda C; Glenn, Stuart B; Nath, Swapan K; Freedman, Barry I; Tsao, Betty P; Kamen, Diane L; Brown, Elizabeth E; Gilkeson, Gary S; Alarcón, Graciela S; Reveille, John D; James, Judith A; Criswell, Lindsey A; Vilá, Luis M; Alarcón-Riquelme, Marta E; Petri, Michelle; Scofield, R Hal; Kimberly, Robert P; Ramsey-Goldman, Rosalind; Bae, Sang-Cheol; Graham, Deborah Cunninghame; Vyse, Timothy J; Guthridge, Joel M; Gaffney, Patrick M; Langefeld, Carl D; Kelly, Jennifer A; Kaufman, Kenneth M; Sivils, Kathy; Harley, John B; Shen, Nan; Lawson, Lucinda P; Baglaenko, Yuriy; Miraldi, Emily R; Rosenberg, Brad R; Siggers, Trevor; Waggoner, Stephen N; Weirauch, Matthew T; Kottyan, Leah C
