日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome.

MDI-114215 的发现:一种强效且选择性的 LIMK 抑制剂,可用于治疗脆性 X 综合征

Baldwin Alex G, Foley David W, Collins Ross, Lee Hyunah, Jones D Heulyn, Wahab Ben, Waters Loren, Pedder Josephine, Paine Marie, Feng Gui Jie, Privitera Lucia, Ashall-Kelly Alexander, Thomas Carys, Gillespie Jason A, Schino Lauramariú, Belelli Delia, Rocha Cecilia, Maussion Gilles, Krahn Andrea I, Durcan Thomas M, Elkins Jonathan M, Lambert Jeremy J, Atack John R, Ward Simon E

Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase

酪氨酸121的移动暴露出一个配体结合口袋,该口袋将丝氨酸消旋酶的催化作用与ATP结合偶联起来。

Koulouris, Chloe R; Gardiner, Sian E; Harris, Tessa K; Elvers, Karen T; Mark Roe, S; Gillespie, Jason A; Ward, Simon E; Grubisha, Olivera; Nicholls, Robert A; Atack, John R; Bax, Benjamin D