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Pharmacological inhibition of the Janus Kinases enhances ASCL1 protein stability and transcriptional activity.

Janus激酶的药理学抑制可增强ASCL1蛋白的稳定性和转录活性

期刊:Molecular Biology Reports

影响因子:2.8

doi:10.1007/s11033-025-10367-9

Hanspal Maya A, Presland Jeremy, Shkura Kirill, Veiga Martina Koeva, Gillotin SÃ©bastien

Inhibition of histone lysine demethylase restores learning and memory in aged mice

抑制组蛋白赖氨酸去甲基化酶可恢复老年小鼠的学习和记忆能力

期刊:

影响因子:

doi:10.64898/2025.12.22.695858

Bhatt, Shail U; MacBean, Lachlan; Kramár, Enikö; Pérez-Sisqués, Leticia; Smethurst, Phillip; Robb, Josephine L; Jindal, Neeru; Fetterly, Tracy L; Graham, Andrew; Wood, Marcelo A; Gillotin, Sébastien; Giese, K Peter; Basson, M Albert

表观遗传

发表日期：2025

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Disrupting the interaction between AMBRA1 and DLC1 prevents apoptosis while enhancing autophagy and mitophagy

破坏 AMBRA1 和 DLC1 之间的相互作用可防止细胞凋亡，同时增强自噬和线粒体自噬

期刊:Biology Open

影响因子:1.8

doi:10.1242/bio.060380

Kate Hawkins, Meg Watt, Sébastien Gillotin, Maya Hanspal, Martin Helley, Jill Richardson, Nicola Corbett, Janet Brownlees

Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells

神经原素 3 磷酸化控制胰腺导管类器官重编程为内分泌细胞的效率

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-018-33838-5

Roberta Azzarelli, Steffen Rulands, Sonia Nestorowa, John Davies, Sara Campinoti, Sébastien Gillotin, Paola Bonfanti, Berthold Göttgens, Meritxell Huch, Benjamin Simons, Anna Philpott

Subcellular localisation modulates ubiquitylation and degradation of Ascl1

亚细胞定位调节 Ascl1 的泛素化和降解

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-018-23056-4

Sébastien Gillotin, John D Davies, Anna Philpott

Isolation of Chromatin-bound Proteins from Subcellular Fractions for Biochemical Analysis

从亚细胞级分中分离染色质结合蛋白用于生化分析

期刊:Bio-protocol

影响因子:1

doi:10.21769/BioProtoc.3035

Micro-chromatin Immunoprecipation (μChIP) Protocol for Real-time PCR Analysis of a Limited Amount of Cells

用于对有限量细胞进行实时 PCR 分析的微染色质免疫沉淀 (μChIP) 方案

期刊:Bio-protocol

影响因子:1

doi:10.21769/BioProtoc.1846

Sébastien Gillotin, François Guillemot

Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes

促神经因子和REST在调控星形胶质细胞神经元重编程中的转录机制

期刊:Cell Stem Cell

影响因子:20.4

doi:10.1016/j.stem.2015.05.014

Masserdotti, Giacomo; Gillotin, Sébastien; Sutor, Bernd; Drechsel, Daniela; Irmler, Martin; Jørgensen, Helle F; Sass, Steffen; Theis, Fabian J; Beckers, Johannes; Berninger, Benedikt; Guillemot, François; Götz, Magdalena

Ascl1 Coordinately Regulates Gene Expression and the Chromatin Landscape during Neurogenesis

Ascl1在神经发生过程中协同调控基因表达和染色质结构

期刊:Cell Reports

影响因子:6.9

doi:10.1016/j.celrep.2015.02.025

Raposo, Alexandre A S F; Vasconcelos, Francisca F; Drechsel, Daniela; Marie, Corentine; Johnston, Caroline; Dolle, Dirk; Bithell, Angela; Gillotin, Sébastien; van den Berg, Debbie L C; Ettwiller, Laurence; Flicek, Paul; Crawford, Gregory E; Parras, Carlos M; Berninger, Benedikt; Buckley, Noel J; Guillemot, François; Castro, Diogo S

信号转导

发表日期：2015

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Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies

双重靶向UPS和自噬作为治疗神经退行性蛋白病的新疗法

Pharmacological inhibition of the Janus Kinases enhances ASCL1 protein stability and transcriptional activity.

Janus激酶的药理学抑制可增强ASCL1蛋白的稳定性和转录活性

Inhibition of histone lysine demethylase restores learning and memory in aged mice

抑制组蛋白赖氨酸去甲基化酶可恢复老年小鼠的学习和记忆能力

Disrupting the interaction between AMBRA1 and DLC1 prevents apoptosis while enhancing autophagy and mitophagy

破坏 AMBRA1 和 DLC1 之间的相互作用可防止细胞凋亡，同时增强自噬和线粒体自噬

Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells

神经原素 3 磷酸化控制胰腺导管类器官重编程为内分泌细胞的效率

Subcellular localisation modulates ubiquitylation and degradation of Ascl1

亚细胞定位调节 Ascl1 的泛素化和降解

Isolation of Chromatin-bound Proteins from Subcellular Fractions for Biochemical Analysis

从亚细胞级分中分离染色质结合蛋白用于生化分析

Micro-chromatin Immunoprecipation (μChIP) Protocol for Real-time PCR Analysis of a Limited Amount of Cells

用于对有限量细胞进行实时 PCR 分析的微染色质免疫沉淀 (μChIP) 方案

Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes

促神经因子和REST在调控星形胶质细胞神经元重编程中的转录机制

Ascl1 Coordinately Regulates Gene Expression and the Chromatin Landscape during Neurogenesis

Ascl1在神经发生过程中协同调控基因表达和染色质结构