Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma
黑色素瘤中MEK2突变和BRAF扩增同时发生会导致对BRAF和MEK抑制剂产生耐药性。
期刊:Cell Reports
影响因子:6.9
doi:10.1016/j.celrep.2013.08.023
Villanueva, Jessie; Infante, Jeffrey R; Krepler, Clemens; Reyes-Uribe, Patricia; Samanta, Minu; Chen, Hsin-Yi; Li, Bin; Swoboda, Rolf K; Wilson, Melissa; Vultur, Adina; Fukunaba-Kalabis, Mizuho; Wubbenhorst, Bradley; Chen, Thomas Y; Liu, Qin; Sproesser, Katrin; DeMarini, Douglas J; Gilmer, Tona M; Martin, Anne-Marie; Marmorstein, Ronen; Schultz, David C; Speicher, David W; Karakousis, Giorgos C; Xu, Wei; Amaravadi, Ravi K; Xu, Xiaowei; Schuchter, Lynn M; Herlyn, Meenhard; Nathanson, Katherine L