日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Hepatic zonation determines tumorigenic potential of mutant β-catenin.

肝脏分区决定突变β-catenin的致瘤潜力。

Raven Alexander, Gilroy Kathryn, Jin Hu, Waldron Joseph A, Leslie Holly, Munro June, Hall Holly, Ridgway Rachel A, Ford Catriona A, Gulhan Doga C, Vlahov Nikola, Mills Megan L, Hartley Andrew, Anderson Eve, Bryson Sheila, Sphyris Nathalie, Müller Miryam, May Stephanie, Cadden Barbara, Nixon Colin, Waddell Scott H, Guest Rachel, Boulter Luke, Barker Nick, Clevers Hans, Zhu Hao, Ivaska Johanna, Strathdee Douglas, Miller Crispin J, Jamieson Nigel B, Bushell Martin, Park Peter J, Bird Thomas G, Sansom Owen J

Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation

核磷蛋白支持WNT信号通路驱动的过度增殖和肿瘤起始

Kanellos, Georgios; Giacomelli, Chiara; Raven, Alexander; Vlahov, Nikola; Jin, Hu; Herviou, Pauline; Malla, Sudhir B; Nasreddin, Nadia; Centeno, Patricia P; Alexandrou, Constantinos; Gilroy, Kathryn; Baird, Rachel L; Pennel, Kathryn; Munro, June; Waldron, Joseph A; Hall, Holly; Officer-Jones, Leah; Bryson, Sheila; Strathdee, Douglas; Lilla, Sergio; Zanivan, Sara; Morrison, Vivienne; Nixon, Colin; Ridgway, Rachel A; Miller, Crispin; Knight, John R P; Campbell, Andrew D; Dunne, Philip D; Le Quesne, John; Edwards, Joanne; Park, Peter J; Bushell, Martin; Sansom, Owen J

Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer.

结直肠癌肿瘤微环境的治疗性调控和空间定量分析。

Mulholland-Illingworth Eoghan J, Moore Joshua W, Lin Muyang, Amirkhah Raheleh, Grzesiak Lucile, Ligeza Amelia, Bull Joshua A, Boen Joseph, Valbuena Gabriel N, Gillespie Michael A, Lannagan Tamsin R M, Gilroy Kathryn, Mills Megan L, Corry Shania M, Ridgway Rachel A, Belnoue-Davis Hayley L, Dunne Philip D, Sansom Owen J, Byrne Helen M, Leedham Simon J

Inactivation of Histone Chaperone HIRA Unmasks a Link Between Normal Embryonic Development of Melanoblasts and Maintenance of Adult Melanocyte Stem Cells.

组蛋白伴侣 HIRA 的失活揭示了黑素细胞正常胚胎发育与成体黑素干细胞维持之间的联系

Jaber-Hijazi Farah, Arnold Rouven, Swaminathan Karthic, Gilroy Kathryn, Wenzel Alexander T, Lagnado Anthony, Kirschner Kristina, Robertson Neil, Reid Claire, Fullarton Neil, Pawlikowski Jeff, Rai Taranjit Singh, Baranyk Ian, Shi Christina Huan, Yip Kevin Y, Blyth Karen, Mesirov Jill P, Harris Melissa L, Passos João F, Machesky Laura M, Adams Peter D

WNT signalling promotes NF-κB activation and drug resistance in KRAS-mutant colorectal cancer.

WNT 信号通路促进 KRAS 突变型结直肠癌中 NF-κB 的激活和耐药性。

Cong Bojie, Stamou Evangelia, Pennel Kathryn, Thakur Teena, Mckenzie Molly, Matly Amna, Gilroy Kathryn, Shah Harshit, Gopinath Sindhura, Edwards Joanne, Cagan Ross

Correction: Characterizing Neutrophil Subtypes in Cancer Using scRNA Sequencing Demonstrates the Importance of IL1β/CXCR2 Axis in Generation of Metastasis-Specific Neutrophils

更正:利用单细胞RNA测序对癌症中性粒细胞亚型进行表征,揭示了IL1β/CXCR2轴在转移特异性中性粒细胞生成中的重要性

Fetit, Rana; McLaren, Alistair S; White, Mark; Mills, Megan L; Falconer, John; Cortes-Lavaud, Xabier; Gilroy, Kathryn; Lannagan, Tamsin R M; Ridgway, Rachel A; Nixon, Colin; Naiker, Varushka; Njunge, Renee; Clarke, Cassie J; Whyte, Declan; Kirschner, Kristina; Jackstadt, Rene; Norman, Jim; Carlin, Leo M; Campbell, Andrew D; Sansom, Owen J; Steele, Colin W

Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer

作者更正:通路水平亚型分析识别出一种与结直肠癌不良临床结局相关的慢周期生物学表型

Malla, Sudhir B; Byrne, Ryan M; Lafarge, Maxime W; Corry, Shania M; Fisher, Natalie C; Tsantoulis, Petros K; Mills, Megan L; Ridgway, Rachel A; Lannagan, Tamsin R M; Najumudeen, Arafath K; Gilroy, Kathryn L; Amirkhah, Raheleh; Maguire, Sarah L; Mulholland, Eoghan J; Belnoue-Davis, Hayley L; Grassi, Elena; Viviani, Marco; Rogan, Emily; Redmond, Keara L; Sakhnevych, Svetlana; McCooey, Aoife J; Bull, Courtney; Hoey, Emily; Sinevici, Nicoleta; Hall, Holly; Ahmaderaghi, Baharak; Domingo, Enric; Blake, Andrew; Richman, Susan D; Isella, Claudio; Miller, Crispin; Bertotti, Andrea; Trusolino, Livio; Loughrey, Maurice B; Kerr, Emma M; Tejpar, Sabine; Maughan, Timothy S; Lawler, Mark; Campbell, Andrew D; Leedham, Simon J; Koelzer, Viktor H; Sansom, Owen J; Dunne, Philip D

CXCR2 inhibition enables NASH-HCC immunotherapy

CXCR2抑制可实现NASH-HCC免疫治疗

Leslie, Jack; Mackey, John B G; Jamieson, Thomas; Ramon-Gil, Erik; Drake, Thomas M; Fercoq, Frédéric; Clark, William; Gilroy, Kathryn; Hedley, Ann; Nixon, Colin; Luli, Saimir; Laszczewska, Maja; Pinyol, Roser; Esteban-Fabró, Roger; Willoughby, Catherine E; Haber, Philipp K; Andreu-Oller, Carmen; Rahbari, Mohammad; Fan, Chaofan; Pfister, Dominik; Raman, Shreya; Wilson, Niall; Müller, Miryam; Collins, Amy; Geh, Daniel; Fuller, Andrew; McDonald, David; Hulme, Gillian; Filby, Andrew; Cortes-Lavaud, Xabier; Mohamed, Noha-Ehssan; Ford, Catriona A; Raffo Iraolagoitia, Ximena L; McFarlane, Amanda J; McCain, Misti V; Ridgway, Rachel A; Roberts, Edward W; Barry, Simon T; Graham, Gerard J; Heikenwälder, Mathias; Reeves, Helen L; Llovet, Josep M; Carlin, Leo M; Bird, Thomas G; Sansom, Owen J; Mann, Derek A

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia

结直肠肿瘤中动态和适应性癌症干细胞群的混合

Gil Vazquez, Ester; Nasreddin, Nadia; Valbuena, Gabriel N; Mulholland, Eoghan J; Belnoue-Davis, Hayley L; Eggington, Holly R; Schenck, Ryan O; Wouters, Valérie M; Wirapati, Pratyaksha; Gilroy, Kathryn; Lannagan, Tamsin R M; Flanagan, Dustin J; Najumudeen, Arafath K; Omwenga, Sulochana; McCorry, Amy M B; Easton, Alistair; Koelzer, Viktor H; East, James E; Morton, Dion; Trusolino, Livio; Maughan, Timothy; Campbell, Andrew D; Loughrey, Maurice B; Dunne, Philip D; Tsantoulis, Petros; Huels, David J; Tejpar, Sabine; Sansom, Owen J; Leedham, Simon J

MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice

MCL1是维持小鼠肠道稳态和预防致癌作用所必需的

Healy, Marc E; Boege, Yannick; Hodder, Michael C; Böhm, Friederike; Malehmir, Mohsen; Scherr, Anna-Lena; Jetzer, Jasna; Chan, Lap Kwan; Parrotta, Rossella; Jacobs, Kurt; Clerbaux, Laure-Alix; Kreutzer, Susanne; Campbell, Andrew; Gilchrist, Ella; Gilroy, Kathryn; Rodewald, Ann-Katrin; Honcharova-Biletska, Hanna; Schimmer, Roman; Vélez, Karelia; Büeler, Simone; Cammareri, Patrizia; Kalna, Gabriela; Wenning, Anna S; McCoy, Kathy D; Gomez de Agüero, Mercedes; Schulze-Bergkamen, Henning; Klose, Christoph S N; Unger, Kristian; Macpherson, Andrew J; Moor, Andreas E; Köhler, Bruno; Sansom, Owen J; Heikenwälder, Mathias; Weber, Achim