日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Nanobodies targeting the tumor microenvironment and their formulation as nanomedicines

靶向肿瘤微环境的纳米抗体及其纳米药物制剂

Maksymova, Liudmyla; Pilger, Yannick A; Nuhn, Lutz; Van Ginderachter, Jo A

Depleting IL1R2+ Tumor-Infiltrating Regulatory T Cells with an ADCC-Prone Nanobody Construct Boosts the Efficacy of Anti-PD-1 Immunotherapy

利用易发生抗体依赖性细胞毒性(ADCC)的纳米抗体构建体清除肿瘤浸润的IL1R2+调节性T细胞,可提高抗PD-1免疫疗法的疗效。

Sana M Arnouk ,Daliya Kancheva ,Helena Van Damme ,Guillaume E Courtoy ,Romina Mora Barthelmess ,Jolien Van Craenenbroeck ,Els Lebegge ,Yvon Elkrim ,Naela Assaf ,Yves Heremans ,Aleksandar Murgaski ,Timo W M De Groof ,Emile Clappaert ,Ayla Debraekeleer ,Jan Brughmans ,Gillian Blancke ,Máté Kiss ,Ramses Forsyth ,Wim Waelput ,Louis Boon ,Nick Devoogdt ,Catelijne Stortelers ,Nadja van Boxel ,Bruno Dombrecht ,Lars Vereecke ,Cécile Vincke ,Geert Raes ,Damya Laoui ,Jo A Van Ginderachter

Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment.

外周单核细胞的表观基因组预处理决定了它们对肿瘤微环境的转录反应

Kiss Máté, Halasz Laszlo, Hadadi Eva, Berger Wilhelm K, Tzerpos Petros, Poliska Szilard, Kancheva Daliya, Gabriel Aurélie, Mora Barthelmess Romina, Debraekeleer Ayla, Brughmans Jan, Elkrim Yvon, Martens Liesbet, Saeys Yvan, Daniel Bence, Czimmerer Zsolt, Laoui Damya, Nagy Laszlo, Van Ginderachter Jo A

Development of a camelid single-domain antibody-based antigen detection assay for the pan-specific diagnosis of active human and animal Trypanosoma brucei infections

开发一种基于骆驼科动物单域抗体的抗原检测方法,用于对人类和动物的活动性布氏锥虫感染进行泛特异性诊断。

Li, Zeng; Jin, Bo-Kyung; Moreno, Emily Estefania Timaury; Álvarez-Rodríguez, Andrés; Ginderachter, Jo A Van; Radwanska, Magdalena; Sterckx, Yann G-J; Stijlemans, Benoit; Magez, Stefan

VSIG4 Is Dispensable for Tumor Growth and Metastasis in Murine Colorectal and Breast Cancer Models

在小鼠结直肠癌和乳腺癌模型中,VSIG4 对肿瘤生长和转移并非必需。

Lebegge, Els; Jumapili, Neema Ahishakiye; Van Craenenbroeck, Jolien; Kancheva, Daliya; Kiss, Máté; Mora Barthelmess, Romina; Hamouda, Ahmed E I; Elkrim, Yvon; Raes, Geert; Hadadi, Éva; Laoui, Damya; Van Ginderachter, Jo A; Arnouk, Sana M

VSIG4-Expressing Macrophages Contribute to Antiparasitic and Antimetastatic Responses in the Peritoneal Cavity

表达VSIG4的巨噬细胞在腹腔内发挥抗寄生虫和抗转移作用

Lebegge, Els; Kancheva, Daliya; Van Craenenbroeck, Jolien; Ernst, Sam; Bardet, Pauline M R; Caro, Aarushi A; Kiss, Máté; Jumapili, Neema Ahishakiye; Barthelmess, Romina Mora; Zivalj, Maida; Assaf, Naela; Ali, Leen; Elkrim, Yvon; Demuytere, Jesse; De Jonge, Jan; Raes, Geert; Hadadi, Eva; Devoogdt, Nick; Vincke, Cécile; Mohavedi, Kiavash; Vereecke, Lars; Ceelen, Wim; Stijlemans, Benoit; Laoui, Damya; Arnouk, Sana M; Van Ginderachter, Jo A

IL-10 Plays a Critical Role in Mitigating Acute Anaemia Development During African Trypanosome Infection

IL-10在减轻非洲锥虫感染引起的急性贫血发展中起着关键作用

Živalj, Maida; St Martin, Anaïs; De Baetselier, Patrick; Maksymova, Liudmyla; Berghmans, Fara; Boon, Louis; Van Ginderachter, Jo A; Magez, Stefan; De Trez, Carl; Stijlemans, Benoit

Development and evaluation of a single domain antibody targeting folate receptor alpha for radioligand therapy

针对叶酸受体α的单域抗体的开发和评估,用于放射性配体治疗

Jonatan Dewulf, Sam Massa, Laurent Navarro, Yana Dekempeneer, Francis Santens, Hannelore Ceuppens, Karine Breckpot, Jo A Van Ginderachter, Tony Lahoutte, Matthias D'Huyvetter, Nick Devoogdt

Imaging of tumor-associated macrophage dynamics during immunotherapy using a CD163-specific nanobody-based immunotracer

利用基于 CD163 特异性纳米抗体的免疫示踪剂对免疫治疗期间肿瘤相关巨噬细胞的动态变化进行成像

Lauwers, Yoline; De Groof, Timo W M; Vincke, Cécile; Van Craenenbroeck, Jolien; Jumapili, Neema Ahishakiye; Barthelmess, Romina Mora; Courtoy, Guillaume; Waelput, Wim; De Pauw, Tessa; Raes, Geert; Devoogdt, Nick; Van Ginderachter, Jo A

Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β

利用针对人CD8β的纳米抗体放射性示踪剂对CD8+T细胞动态进行特异性成像

De Groof, Timo W M; Lauwers, Yoline; De Pauw, Tessa; Saxena, Mohit; Vincke, Cécile; Van Craenenbroeck, Jolien; Chapon, Catherine; Le Grand, Roger; Raes, Geert; Naninck, Thibaut; Van Ginderachter, Jo A; Devoogdt, Nick