日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein.

通过靶向细胞表面 RNA 结合蛋白治疗急性髓系白血病模型。

George Benson M, Eleftheriou Maria, Yankova Eliza, Perr Jonathan, Chai Peiyuan, Nestola Gianluca, Almahayni Karim, Evans Siân, Damaskou Aristi, Hemberger Helena, Lebedenko Charlotta G, Rak Justyna, Yu Qi, Bapcum Ece, Russell James, Bagri Jaana, Volk Regan F, Spiekermann Malte, Stone Richard M, Giotopoulos George, Huntly Brian J P, Baxter Joanna, Camargo Fernando, Liu Jie, Zaro Balyn W, Vassiliou George S, Möckl Leonhard, de la Rosa Jorge, Flynn Ryan A, Tzelepis Konstantinos

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

线粒体代谢维持DNMT3A-R882突变克隆性造血

Malgorzata Gozdecka ,Monika Dudek # ,Sean Wen # ,Muxin Gu ,Richard J Stopforth ,Justyna Rak ,Aristi Damaskou ,Guinevere L Grice ,Matthew A McLoughlin ,Laura Bond ,Rachael Wilson ,George Giotopoulos ,Vijaya Mahalingam Shanmugiah ,Rula Bany Bakar ,Eliza Yankova ,Jonathan L Cooper ,Nisha Narayan ,Sarah J Horton ,Ryan Asby ,Dean C Pask ,Annalisa Mupo ,Graham Duddy ,Ludovica Marando ,Theodoros Georgomanolis ,Paul Carter ,Amirtha Priya Ramesh ,William G Dunn ,Clea Barcena ,Paolo Gallipoli ,Kosuke Yusa ,Slavé Petrovski ,Penny Wright ,Pedro M Quiros ,Christian Frezza ,James A Nathan ,Arthur Kaser ,Siddhartha Kar ,Konstantinos Tzelepis ,Jonathan Mitchell ,Margarete A Fabre ,Brian J P Huntly ,George S Vassiliou

Evidence of miR‐153‐3p association with Alzheimer's disease (AD) and the mechanism of miR‐153‐3p on critical proteins suggest a therapeutic and biomarker potential of miR‐153‐3p in AD and related dementias

miR-153-3p与阿尔茨海默病(AD)的关联证据以及miR-153-3p对关键蛋白的作用机制表明,miR-153-3p在AD及相关痴呆症中具有治疗和生物标志物方面的潜力。

Shah, Viral; Giotopoulos, George; Osaki, Hikari; Meyerhöfer, Markus; Meduri, Eshwar; Gallego-Crespo, Aaron; Behrendt, Malte A; Saura-Pañella, Maria; Tarkar, Aarti; Schubert, Benedict; Yun, Haiyang; Horton, Sarah J; Agrawal-Singh, Shuchi; Haehnel, Patricia S; Basheer, Faisal; Lugo, Dave; Eleftheriadou, Ioanna; Barbash, Olena; Dhar, Arindam; Kühn, Michael W M; Guezguez, Borhane; Theobald, Matthias; Kindler, Thomas; Gallipoli, Paolo; Yeh, Paul; Dawson, Mark A; Prinjha, Rab K; Huntly, Brian J P; Sasca, Daniel; Fish, Lauren A; Canchi, Saranya; Telpoukhovskaia, Maria; Luquez, Tain; Algoo, Jonathan; Hadad, Niran; Gurdon, Brianna; Dai, Miko; Ouellette, Andrew R; Neuner, Sarah M; Dunn, Amy R; Willcox, Jon A L; Wu, Yiyang; Dumitrescu, Logan; Bellur, Orhan; Zhang, Jigang; O'Connell, Kristen MS; Dammer, Eric B; Seyfried, Nicholas T; Muzumdar, Sukalp; Gillis, Jesse; Robson, Paul; Arnold, Matthias; Hohman, Timothy J; Philip, Vivek M; Menon, Vilas; Kaczorowski, Catherine C; Lahiri, Debomoy K; Wang, Ruizhi; Maloney, Bryan; Ghetti, Bernardino; Nho, Kwangsik; Farlow, Martin R; Saykin, Andrew J; White, Fletcher A; Sambamurti, Kumar; Counts, Scott E; Rosene, Matthew J; Lopez, Abraham; Ahmad, Adeeb; Romero, Skarleth Cardenas; Lai, Mei‐Yu; Benitez, Bruno A; Tish, Margaret M; Gao, Lauren; Ou, Zihui; Weinshenker, David; Birey, Fikri; Lahiri, Debomoy K; Wang, Ruizhi; Maloney, Bryan; Ghetti, Bernardino; Nho, Kwangsik; Farlow, Martin R; Saykin, Andrew J; White, Fletcher A; Sambamurti, Kumar; Counts, Scott E

CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition

CREBBP失活使B细胞急性淋巴细胞白血病对BCL2抑制引起的铁死亡更加敏感

Alicia Garcia-Gimenez ,Jonathan E Ditcham ,Dhoyazan M A Azazi ,George Giotopoulos ,Ryan Asby ,Eshwar Meduri ,Jaana Bagri ,Nathalie Sakakini ,Cecile K Lopez ,Nisha Narayan ,Tumas Beinortas ,Shuchi Agrawal-Singh ,Kent Fung ,David O'Connor ,Marc R Mansour ,Husam B R Alabed ,Benjamin Jenkins ,Albert Koulman ,Michael P Murphy ,Sarah J Horton ,Brian J P Huntly ,Simon E Richardson

In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis

体内筛选表征正常和恶性造血过程中染色质因子的功能

David Lara-Astiaso #, Ainhoa Goñi-Salaverri #, Julen Mendieta-Esteban #, Nisha Narayan, Cynthia Del Valle, Torsten Gross, George Giotopoulos, Tumas Beinortas, Mar Navarro-Alonso, Laura Pilar Aguado-Alvaro, Jon Zazpe, Francesco Marchese, Natalia Torrea, Isabel A Calvo, Cecile K Lopez, Diego Alignani,

HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia

HOXA9 与核基质相关蛋白 SAFB 形成抑制复合物,以维持急性髓系白血病。

Agrawal-Singh, Shuchi; Bagri, Jaana; Giotopoulos, George; Azazi, Dhoyazan M A; Horton, Sarah J; Lopez, Cecile K; Anand, Shubha; Bach, Anne-Sophie; Stedham, Frances; Antrobus, Robin; Houghton, Jack W; Vassiliou, George S; Sasca, Daniel; Yun, Haiyang; Whetton, Anthony D; Huntly, Brian J P

Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death

甘露糖代谢抑制通过诱导铁死亡使急性髓系白血病细胞对治疗更加敏感

Keith Woodley ,Laura S Dillingh ,George Giotopoulos ,Pedro Madrigal ,Kevin M Rattigan ,Céline Philippe ,Vilma Dembitz ,Aoife M S Magee ,Ryan Asby ,Louie N van de Lagemaat ,Christopher Mapperley ,Sophie C James ,Jochen H M Prehn ,Konstantinos Tzelepis ,Kevin Rouault-Pierre ,George S Vassiliou ,Kamil R Kranc ,G Vignir Helgason ,Brian J P Huntly ,Paolo Gallipoli

Preleukemic single-cell landscapes reveal mutation-specific mechanisms and gene programs predictive of AML patient outcomes

白血病前期单细胞图谱揭示了突变特异性机制和基因程序,这些机制和程序可预测急性髓系白血病(AML)患者的预后。

Tomoya Isobe ,Iwo Kucinski ,Melania Barile ,Xiaonan Wang ,Rebecca Hannah ,Hugo P Bastos ,Shirom Chabra ,M S Vijayabaskar ,Katherine H M Sturgess ,Matthew J Williams ,George Giotopoulos ,Ludovica Marando ,Juan Li ,Justyna Rak ,Malgorzata Gozdecka ,Daniel Prins ,Mairi S Shepherd ,Sam Watcham ,Anthony R Green ,David G Kent ,George S Vassiliou ,Brian J P Huntly ,Nicola K Wilson ,Berthold Göttgens

Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma

无偏细胞表面蛋白质组学鉴定出 SEMA4A 是骨髓瘤的有效免疫治疗靶点

Georgina S F Anderson, Jose Ballester-Beltran, George Giotopoulos, Jose A Guerrero, Sylvanie Surget, James C Williamson, Tsz So, David Bloxham, Anna Aubareda, Ryan Asby, Ieuan Walker, Lesley Jenkinson, Elizabeth J Soilleux, James P Roy, Ana Teodósio, Catherine Ficken, Leah Officer-Jones, Sara Nasser

Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis

转录变异通过细胞多样化和扰乱蛋白质合成加速白血病前期进程

Shikha Gupta ,Oliver M Dovey ,Ana Filipa Domingues ,Oliwia W Cyran ,Caitlin M Cash ,George Giotopoulos ,Justyna Rak ,Jonathan Cooper ,Malgorzata Gozdecka ,Liza Dijkhuis ,Ryan J Asby ,Noor Al-Jabery ,Victor Hernandez-Hernandez ,Sudhakaran Prabakaran ,Brian J Huntly ,George S Vassiliou ,Cristina Pina