日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

IFN-γ-resistant CD28 CAR T cells demonstrate increased survival, efficacy, and durability in multiple murine tumor models

在多种小鼠肿瘤模型中,抗IFN-γ的CD28 CAR T细胞表现出更高的存活率、疗效和持久性。

Stefanie R Bailey ,Hana N Takei ,Giulia Escobar ,Michael C Kann ,Amanda A Bouffard ,Tamina Kienka ,Valentina M Supper ,Alexander Armstrong ,Diego Salas-Benito ,Merle K Phillips ,Filippo Birocchi ,Sonika Vatsa ,Harrison Silva ,Irene Scarfò ,Marc Wehrli ,Korneel Grauwet ,Eli P Darnell ,Charlotte E Graham ,Mark B Leick ,Felix Korell ,Trisha R Berger ,Marcela V Maus

CAR-T cell therapy targeting MUC17 in gastric tumors

靶向MUC17的CAR-T细胞疗法治疗胃肿瘤

Sangwoo Park ,Cassidy E Ho ,Filippo Birocchi ,Alexandra N Wolff ,Amanda A Bouffard ,Christopher Kelly ,Diego Salas-Benito ,Giulia Escobar ,Adele Mucci ,Trisha Berger ,Marcela V Maus

Tandem CAR-T cells targeting mesothelin and MUC16 overcome tumor heterogeneity by targeting one antigen at a time

靶向间皮素和MUC16的串联CAR-T细胞通过一次靶向一种抗原来克服肿瘤异质性。

Diego Salas-Benito ,Filippo Birocchi ,Sangwoo Park ,Cassidy E Ho ,Alexander Armstrong ,Aiyana L Parker ,Amanda A Bouffard ,Jessica A Frank ,Eugene Kim ,Tamina Kienka ,Kiana Graham ,Christopher Kelly ,Sadie Goncalves ,Mark B Leick ,Giulia Escobar ,Bo Rueda ,Trisha R Berger ,Marcela V Maus MD,

Transcription factor TCF1 binds to RORγt and orchestrates a regulatory network that determines homeostatic Th17 cell state

转录因子TCF1与RORγt结合,并协调一个决定Th17细胞稳态的调控网络。

Davide Mangani ,Ayshwarya Subramanian ,Linglin Huang ,Hanning Cheng ,S Harsha Krovi ,Yufan Wu ,Dandan Yang ,Thais G Moreira ,Giulia Escobar ,Alexandra Schnell ,Karen O Dixon ,Rajesh K Krishnan ,Vasundhara Singh ,Raymond A Sobel ,Howard L Weiner ,Vijay K Kuchroo ,Ana C Anderson

Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity

对单个CD8+ T细胞谱进行泛癌定位分析,揭示了TCF1:CXCR6轴调控CD28共刺激和抗肿瘤免疫的作用。

Katherine Tooley ,Livnat Jerby ,Giulia Escobar ,S Harsha Krovi ,Davide Mangani ,Gitanjali Dandekar ,Hanning Cheng ,Asaf Madi ,Ella Goldschmidt ,Conner Lambden ,Rajesh K Krishnan ,Orit Rozenblatt-Rosen ,Aviv Regev ,Ana C Anderson

Tumor immunogenicity dictates reliance on TCF1 in CD8+ T cells for response to immunotherapy

肿瘤免疫原性决定了CD8+ T细胞对免疫疗法反应的依赖性。

Giulia Escobar ,Katherine Tooley ,Joan Pagès Oliveras ,Linglin Huang ,Hanning Cheng ,Michelle L Bookstaver ,Camilla Edwards ,Eugene Froimchuk ,Chang Xue ,Davide Mangani ,Rajesh K Krishnan ,Natanael Hazel ,Carola Rutigliani ,Christopher M Jewell ,Luca Biasco ,Ana C Anderson

Spatial determinants of CD8+ T cell differentiation in cancer

癌症中 CD8+ T 细胞分化的空间决定因素

Katherine A Tooley, Giulia Escobar, Ana C Anderson

Myeloid cell-based delivery of IFN-γ reprograms the leukemia microenvironment and induces anti-tumoral immune responses

基于髓系细胞的 IFN-γ 递送可重新编程白血病微环境并诱导抗肿瘤免疫反应

Adele Mucci, Gabriele Antonarelli, Carolina Caserta, Francesco Maria Vittoria, Giacomo Desantis, Riccardo Pagani, Beatrice Greco, Monica Casucci, Giulia Escobar, Laura Passerini, Nico Lachmann, Francesca Sanvito, Matteo Barcella, Ivan Merelli, Luigi Naldini, Bernhard Gentner

Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment

内源性糖皮质激素信号传导调节CD8+ T细胞分化及肿瘤微环境中功能障碍的发生发展

Nandini Acharya ,Asaf Madi ,Huiyuan Zhang ,Max Klapholz ,Giulia Escobar ,Shai Dulberg ,Elena Christian ,Michelle Ferreira ,Karen O Dixon ,Geoffrey Fell ,Katherine Tooley ,Davide Mangani ,Junrong Xia ,Meromit Singer ,Marcus Bosenberg ,Donna Neuberg ,Orit Rozenblatt-Rosen ,Aviv Regev ,Vijay K Kuchroo ,Ana C Anderson

Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1-CD8+ Tumor-Infiltrating T Cells

检查点阻断免疫疗法诱导 PD-1-CD8+ 肿瘤浸润 T 细胞的动态变化

Sema Kurtulus, Asaf Madi, Giulia Escobar, Max Klapholz, Jackson Nyman, Elena Christian, Mathias Pawlak, Danielle Dionne, Junrong Xia, Orit Rozenblatt-Rosen, Vijay K Kuchroo, Aviv Regev, Ana C Anderson