日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Differential downstream signaling in microglia lacking Alzheimer's-related TREM2 or its adaptor TYROBP/DAP12

缺乏阿尔茨海默病相关TREM2或其衔接蛋白TYROBP/DAP12的小胶质细胞中下游信号传导的差异

Farias Quipildor, Gabriela E; Belfiore, Ramona; Althobaiti, Khaled; Najarzadeh, Zahra; Glabe, Charles; Readhead, Benjamin P; Gandy, Sam; Salton, Stephen R J; Ehrlich, Michelle E

Epitomic profiling and functional characteristics of pemphigus vulgaris autoantibody binding to keratinocyte M3 muscarinic acetylcholine receptor

寻常型天疱疮自身抗体与角质形成细胞M3毒蕈碱乙酰胆碱受体结合的表位谱分析和功能特征

Reyes-Ruiz, Jorge Mauricio; Chernyavsky, Alex; Grando, Sergei A; Glabe, Charles

Endogenously generated Dutch-type Aβ nonfibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation

内源性生成的荷兰型Aβ非纤维聚集体在没有可检测到的炎症的情况下会扰乱突触前神经传递。

Castranio, Emilie L; Varghese, Merina; Argyrousi, Elentina K; Tripathi, Kuldeep; Söderberg, Linda; Bresnahan, Erin; Lerner, David; Garretti, Francesca; Zhang, Hong; van de Loo, Jonathan; Stimpson, Cheryl D; Talty, Ronan; Glabe, Charles; Levy, Efrat; Wang, Minghui; Ilkov, Marjan; Zhang, Bin; Lannfelt, Lars; Guérin, Brigitte; Lubell, William D; Rahimipour, Shai; Dickstein, Dara L; Gandy, Sam; Arancio, Ottavio; Ehrlich, Michelle E

Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease

小胶质细胞 INPP5D 限制阿尔茨海默病 PSAPP 小鼠模型中的斑块形成和神经胶质反应性

Emilie L Castranio, Philip Hasel, Jean-Vianney Haure-Mirande, Angie V Ramirez Jimenez, B Wade Hamilton, Rachel D Kim, Charles G Glabe, Minghui Wang, Bin Zhang, Sam Gandy, Shane A Liddelow, Michelle E Ehrlich

Intracellular Injection of Brain Extracts from Alzheimer's Disease Patients Triggers Unregulated Ca(2+) Release from Intracellular Stores That Hinders Cellular Bioenergetics

将阿尔茨海默病患者脑组织提取物注射到细胞内会引发细胞内钙离子储存库中不受控制的钙离子释放,从而阻碍细胞生物能量学。

Pensalfini, Anna; Umar, Abdul Rahim; Glabe, Charles; Parker, Ian; Ullah, Ghanim; Demuro, Angelo

Age-Related Oxidative Redox and Metabolic Changes Precede Intraneuronal Amyloid-β Accumulation and Plaque Deposition in a Transgenic Alzheimer's Disease Mouse Model

在转基因阿尔茨海默病小鼠模型中,与年龄相关的氧化还原和代谢变化先于神经元内淀粉样蛋白-β 积累和斑块沉积

Crystal G Pontrello, Joshua M McWhirt, Charles G Glabe, Gregory J Brewer

Conformation-dependent anti-Aβ monoclonal antibody signatures of disease status and severity in urine of women with preeclampsia

先兆子痫女性尿液中构象依赖性抗Aβ单克隆抗体特征与疾病状态和严重程度的关系

Valtanen, Rosa S; Buhimschi, Catalin S; Bahtiyar, Mert O; Zhao, Guomao; Jing, Hongwu; Ackerman, William E 4th; Glabe, Charles G; Buhimschi, Irina A

Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease

APP合成过程中核糖体停滞的质量控制效率低下,会产生CAT尾状分子,从而引发阿尔茨海默病的典型症状。

Suman Rimal # ,Yu Li # ,Rasika Vartak # ,Ji Geng ,Ishaq Tantray ,Shuangxi Li ,Sungun Huh ,Hannes Vogel ,Charles Glabe ,Lea T Grinberg ,Salvatore Spina ,William W Seeley ,Su Guo ,Bingwei Lu

An "epitomic" analysis of the specificity of conformation-dependent, anti-Aß amyloid monoclonal antibodies

构象依赖性抗 Aβ 淀粉样蛋白单克隆抗体特异性的“表观”分析

Jorge Mauricio Reyes-Ruiz, Rie Nakajima, Ibtisam Baghallab, Luki Goldschmidt, Justyna Sosna, Phuong Nguyen Mai Ho, Taha Kumosani, Philip L Felgner, Charles Glabe

Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease

一种构象抗体的晶体结构,该抗体可结合 tau 寡聚体并抑制阿尔茨海默病患者提取物的病理播散

Romany Abskharon, Paul M Seidler, Michael R Sawaya, Duilio Cascio, Tianxiao P Yang, Stephan Philipp, Christopher Kazu Williams, Kathy L Newell, Bernardino Ghetti, Michael A DeTure, Dennis W Dickson, Harry V Vinters, Philip L Felgner, Rie Nakajima, Charles G Glabe, David S Eisenberg