日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice.

诱导性删除小胶质细胞中的 DGAT1 和 2 会加剧雄性 PS19 小鼠的神经退行性变和内溶酶体脂质积累。

Tabor G Travis, Litvinchuk Alexandra, Chen Yun, Allison Austin, Sun Elizabeth W, van Lengerich Bettina, Davis Sonnet S, West Elizabeth, Schlachetzki Johannes C M, Zeng Carisa, Hu Hao, Lin Peter B, Sharma Prabal, Chen Xiaoying, Parhizkar Samira, Song Sihui, Bao Xin, Senthil Lakshita, Iyer Abhirami K, You Shih Feng, Serrano Javier Remolina, Manis Melissa, Franke Emily, Cashikar Anil G, Yuede Carla M, Suh Jung H, Karch Celeste M, Folick Andrew, Koliwad Suneil K, Farese Robert V Jr, Walther Tobias, Huang Eric J, Artyomov Maxim, Glass Christopher K, Di Paolo Gilbert, Ulrich Jason D, Holtzman David M

Macrophage sensing of the acidic milieu: BRD4 condensates in focus

巨噬细胞对酸性环境的感知:聚焦BRD4凝聚体

Zhang, Dan; Tiwari, Vini; Glass, Christopher K

Multi-modal analysis of human hepatic stellate cells identifies novel therapeutic targets for metabolic dysfunction-associated steatotic liver disease

对人肝星状细胞进行多模态分析,发现了代谢功能障碍相关脂肪肝疾病的新治疗靶点。

Kim, Hyun Young; Rosenthal, Sara Brin; Liu, Xiao; Miciano, Charlene; Hou, Xiaomeng; Miller, Michael; Buchanan, Justin; Poirion, Olivier B; Chilin-Fuentes, Daisy; Han, Cuijuan; Housseini, Mojgan; Carvalho-Gontijo Weber, Raquel; Sakane, Sadatsugu; Lee, Wonseok; Zhao, Huayi; Diggle, Karin; Preissl, Sebastian; Glass, Christopher K; Ren, Bing; Wang, Allen; Brenner, David A; Kisseleva, Tatiana

Self-amplifying NRF2-EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer.

自我扩增的 NRF2-EZH2 表观遗传环将 KRAS 启动的祖细胞转化为侵袭性胰腺癌

Antonucci Laura, Li Na, Duran Angeles, Cobo Isidoro, Nicoletti Chiara, Watari Kosuke, Nandi Shuvro Prokash, Zhu Feng, Zhao Yongmei, Riahi Irene, Tsuda Motoyuki, Shah Vidhi M, Morgan Terry, Waugh Trent, Caputo Luca, Liu Yuan, Rundberg Nilsson Alexandra, Xian Hongxu, Todoric Jelena, Gu Li, Sanchez-Lopez Elsa, Eibl Guido, Vucic Emily A, Krawczyk Michal, Xu Qianlan, Lowy Andrew M, Hatzivassiliou Georgia, Roose-Girma Merone, Skowronska-Krawczyk Dorota, Scott David A, Bar-Sagi Dafna, Tamayo Pablo, Wu Ying, Sears Rosalie C, Glass Christopher K, Alexandrov Ludmil B, Puri Pier Lorenzo, Dawson David W, Hu Yinling, Diaz-Meco Maria T, Moscat Jorge, Karin Michael

Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease

MEF2C在人类小胶质细胞中的转录和表观遗传靶点参与了与自闭症风险和年龄相关疾病相关的细胞功能。

Nguyen, Celina; Broersma, Emily H; Warden, Anna S; Mora, Cristina; Han, Claudia Z; Keulen, Zahara; Spann, Nathanael; Wang, Jing; Ramirez, Gabriela; Mak, Samantha; Trescott, Samantha; Khakpour, Mohammadparsa; Johnson, Avalon; Qureshi, Fatir; La Frano, Michael R; Mohajeri, Kiana; Talkowski, Michael E; Corradin, Olivia; Tremblay, Marie-Ève; Glass, Christopher K; Coufal, Nicole G

Genetic variation in the activity of a TREM2-p53 signaling axis determines oxygen-induced lung injury

TREM2-p53信号通路活性的遗传变异决定了氧诱导的肺损伤。

Abe, Yohei; Spann, Nathanael J; Tang, Wenxi; Zeng, Fenghua; Seymour, Cadence; Jansky, Sean; Guo, Jason L; Huff, Robert; Chanthavixay, Kelly; Richard, John Lalith Charles; Mooney, Miguel; Dhar, Debanjan; Ganguly, Souradipta; Lopez, David M; Longaker, Michael T; Benner, Christopher; Glass, Christopher K; Sajti, Eniko

Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression.

巨噬细胞对颗粒的摄取会触发分叉的转录通路,从而差异性地调节炎症和溶酶体基因表达

Cobo Isidoro, Murillo-Saich Jessica, Alishala Mohnish, Calderon Stephen, Coras Roxana, Hemming Benjamin, Inkum Faith, Rosas Fiorella, Takei Riku, Spann Nathan, Prohaska Thomas A, Alabarse Paulo V G, Jeong Se-Jin, Nickl Christian K, Cheng Anyan, Li Benjamin, Vogel Andrea, Weichhart Thomas, Fuster José J, Le Thomas, Bradstreet Tara R, Webber Ashlee M, Edelson Brian T, Razani Babak, Ebert Benjamin L, Taneja Reshma, Terkeltaub Robert, Bryan Ru Liu, Guma Monica, Glass Christopher K

Microglia networks within the tapestry of alzheimer's disease through spatial transcriptomics

通过空间转录组学揭示阿尔茨海默病中小胶质细胞网络的复杂性

Zhou, Yi; Glass, Christopher K

CCL26 and CXCL12 Promote Release of Insulin-Sensitizing Adipose Tissue Macrophage sEVs from Subcutaneous Adipose Tissue in Obesity.

CCL26 和 CXCL12 促进肥胖患者皮下脂肪组织释放胰岛素增敏脂肪组织巨噬细胞 sEVs

Jeelani Ishtiaq, da Cunha Flavia Franco, Rohm Theresa V, Nasamran Chanond A, Moon Jae-Su, Wang Letian, Prakash Sruthika, Issac Roi, Murphy Cairo, Glass Christopher K, Olefsky Jerrold M, Lee Yun Sok

Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2

脂质相关巨噬细胞在MASH消退过程中促进纤维化消退需要TREM2。

Ganguly, Souradipta; Rosenthal, Sara Brin; Ishizuka, Kei; Troutman, Ty D; Rohm, Theresa V; Khader, Naser; Aleman-Muench, German; Sano, Yasuyo; Archilei, Sebastiano; Soroosh, Pejman; Olefsky, Jerrold M; Feldstein, Ariel E; Kisseleva, Tatiana; Loomba, Rohit; Glass, Christopher K; Brenner, David A; Dhar, Debanjan