日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural basis of THC analog activity at the Cannabinoid 1 receptor.

THC类似物在大麻素1受体上的活性结构基础

Thorsen Thor S, Kulkarni Yashraj, Sykes David A, Bøggild Andreas, Drace Taner, Hompluem Pattarin, Iliopoulos-Tsoutsouvas Christos, Nikas Spyros P, Daver Henrik, Makriyannis Alexandros, Nissen Poul, Gajhede Michael, Veprintsev Dmitry B, Boesen Thomas, Kastrup Jette S, Gloriam David E

PGxDB: an interactive web-platform for pharmacogenomics research

PGxDB:一个用于药物基因组学研究的交互式网络平台

Duong Nguyen, Trinh Trung; Tanoli, Ziaurrehman; Hassan, Saad; Özcan, Umut Onur; Caroli, Jimmy; Kooistra, Albert J; Gloriam, David E; Hauser, Alexander S

Structural basis of Δ9-THC analog activity at the Cannabinoid 1 receptor

Δ9-THC 类似物对大麻素 1 受体活性的结构基础

David Gloriam, Thor Thorsen, Yashraj Kulkarni, David Sykes, Andreas Bøggild, Taner Drace, Pattarin Hompluem, Christos Iliopoulos-Tsoutsouvas, Spyros Nikas, Henrik Daver, Alexandros Makriyannis, Poul Nissen, Michael Gajhede, Dmitry Veprintsev, Thomas Boesen, Jette Kastrup

Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations

Frizzled 中的通路选择性是通过保守的微开关来实现的,这些微开关决定通路决定性的活性构象

Lukas Grätz #, Maria Kowalski-Jahn #, Magdalena M Scharf, Pawel Kozielewicz, Michael Jahn, Julien Bous, Nevin A Lambert, David E Gloriam, Gunnar Schulte

Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity

动态时空决定因素调节 GPCR:G 蛋白偶联选择性和混杂性

Manbir Sandhu, Aaron Cho, Ning Ma, Elizaveta Mukhaleva, Yoon Namkung, Sangbae Lee, Soumadwip Ghosh, John H Lee, David E Gloriam, Stéphane A Laporte, M Madan Babu, Nagarajan Vaidehi1

Ligand-directed bias of G protein signaling at the dopamine D(2) receptor.

多巴胺 D(2) 受体上 G 蛋白信号的配体导向偏向性

Von Moo Ee, Harpsøe Kasper, Hauser Alexander S, Masuho Ikuo, Bräuner-Osborne Hans, Gloriam David E, Martemyanov Kirill A

Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation

利用肽类抑制剂靶向 APP-Mint2 蛋白质间相互作用可减少淀粉样蛋白 β 的形成

Christian R O Bartling, Thomas M T Jensen, Shawna M Henry, Anna L Colliander, Vita Sereikaite, Marcella Wenzler, Palash Jain, Hans M Maric, Kasper Harpsøe, Søren W Pedersen, Louise S Clemmensen, Linda M Haugaard-Kedström, David E Gloriam, Angela Ho, Kristian Strømgaard

A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro

一种新型红色荧光多巴胺生物传感器可在体外选择性检测去甲肾上腺素存在的多巴胺

Chihiro Nakamoto #, Yuhei Goto #, Yoko Tomizawa, Yuko Fukata, Masaki Fukata, Kasper Harpsøe, David E Gloriam, Kazuhiro Aoki, Tomonori Takeuchi

Combinatorial expression of GPCR isoforms affects signalling and drug responses.

GPCR亚型的组合表达会影响信号传导和药物反应

Marti-Solano Maria, Crilly Stephanie E, Malinverni Duccio, Munk Christian, Harris Matthew, Pearce Abigail, Quon Tezz, Mackenzie Amanda E, Wang Xusheng, Peng Junmin, Tobin Andrew B, Ladds Graham, Milligan Graeme, Gloriam David E, Puthenveedu Manojkumar A, Babu M Madan

Delineation of molecular determinants for FR900359 inhibition of Gq/11 unlocks inhibition of Gαs

FR900359 抑制 Gq/11 的分子决定因素的描述揭示了 Gαs 的抑制

Michael W Boesgaard, Kasper Harpsøe, Michelle Malmberg, Christina R Underwood, Asuka Inoue, Jesper M Mathiesen, Gabriele M König, Evi Kostenis, David E Gloriam, Hans Bräuner-Osborne