Glorioso Joseph C相关文献与解析，生知库

Biosafety and efficacy of Kv7 activating rdHSV-CA8∗ analgesic gene therapy for chronic pain via the intra-articular route in mice

Kv7激活rdHSV-CA8*镇痛基因疗法经关节内途径治疗小鼠慢性疼痛的生物安全性和有效性

期刊:Molecular Therapy

影响因子:12

doi:10.1016/j.ymthe.2025.05.029

Levitt, Roy C; Kandel, Munal B; Zhuang, Gerald Z; Goins, William F; Sarantopoulos, Konstantinos D; Glorioso, Joseph C

发表日期：2025

文献求助收藏

Next-generation replication-defective HSV vectors for delivery of large DNA payloads

用于递送大分子DNA载荷的新一代复制缺陷型HSV载体

期刊:Molecular Therapy

影响因子:12

doi:10.1016/j.ymthe.2025.03.055

Ingusci, Selene; Goins, William F; Cohen, Justus B; Miyagawa, Yoshitaka; Knipe, David M; Glorioso, Joseph C

发表日期：2025

文献求助收藏

Viral and cellular insulators promote sustained HSV vector-mediated transgene expression in brain

病毒和细胞绝缘体促进脑内HSV载体介导的转基因持续表达

期刊:Molecular Therapy

影响因子:12

doi:10.1016/j.ymthe.2025.02.039

Ingusci, Selene; Cohen, Justus B; Glorioso, Joseph C

An oncolytic herpes simplex virus armed with IL-12 for treatment of preclinical glioblastoma

一种携带IL-12的溶瘤性单纯疱疹病毒用于治疗临床前胶质母细胞瘤

期刊:Molecular Therapy Oncology

影响因子:5.3

doi:10.1016/j.omton.2025.201030

Jackson, Joseph W; Hall, Bonnie L; Sneiderman, Chaim; Webb, Amy; Hancock, Trevor J; Vlasyuk, Marina; Bailey, Lisa; Xiaokui, Molly; Solomon, Isaac H; Ligon, Keith; Goins, William F; Kohanbash, Gary; Chiocca, E Antonio; Glorioso, Joseph C

Durable tissue-specific transgene expression in newborn mice following intraperitoneal delivery of non-cytotoxic HSV vectors

腹腔注射非细胞毒性HSV载体后，新生小鼠体内可实现持久的组织特异性转基因表达

期刊:Molecular Therapy-Methods & Clinical Development

影响因子:4.7

doi:10.1016/j.omtm.2025.101573

Miyagawa, Yoshitaka; Maruyama, Motoyo; Sakai, Atsushi; Sato, Yuriko; Shimizu, Masumi; Kuroda, Seiji; Hayashita-Kinoh, Hiromi; Yamamoto, Motoko; Hashizume, Ryotaro; Suzuki, Hidenori; Cohen, Justus B; Glorioso, Joseph C; Okada, Takashi

Genetic mutations in HSV-1 replication-defective vectors: Implications for their safety in gene therapy applications.

HSV-1复制缺陷载体中的基因突变：对其在基因治疗应用中安全性的影响。

期刊:Gene Therapy

影响因子:4.5

doi:10.1038/s41434-025-00566-1

Cattaneo Stefano, Bettegazzi Barbara, Ingusci Selene, Verlengia Gianluca, Anna Sofia Tascini, Silvia Zucchini, Codazzi Franca, Morelli Marco J, Marzulli Marco, Glorioso Joseph C, Simonato Michele

基因治疗

发表日期：2025

文献求助收藏

rdHSV-CA8 non-opioid analgesic gene therapy decreases somatosensory neuronal excitability by activating Kv7 voltage-gated potassium channels

rdHSV-CA8非阿片类镇痛基因疗法通过激活Kv7电压门控钾通道降低体感神经元的兴奋性。

期刊:Frontiers in Molecular Neuroscience

影响因子:3.8

doi:10.3389/fnmol.2024.1398839

Kandel, Munal B; Zhuang, Gerald Z; Goins, William F; Marzulli, Marco; Zhang, Mingdi; Glorioso, Joseph C; Kang, Yuan; Levitt, Alexandra E; Kwok, Wai-Meng; Levitt, Roy C; Sarantopoulos, Konstantinos D

神经科学

发表日期：2024

文献求助收藏

Evaluation of parameters for efficient purification and long-term storage of herpes simplex virus-based vectors

评估用于高效纯化和长期储存单纯疱疹病毒载体的参数

期刊:Molecular Therapy-Methods & Clinical Development

影响因子:4.7

doi:10.1016/j.omtm.2022.06.007

Kuroda, Seiji; Miyagawa, Yoshitaka; Sukegawa, Makoto; Tomono, Taro; Yamamoto, Motoko; Adachi, Kumi; Verlengia, Gianluca; Goins, William F; Cohen, Justus B; Glorioso, Joseph C; Okada, Takashi

Cooperation of oncolytic virotherapy with VEGF-neutralizing antibody treatment in IDH wildtype glioblastoma depends on MMP9

在IDH野生型胶质母细胞瘤中，溶瘤病毒疗法与VEGF中和抗体治疗的协同作用依赖于MMP9。

期刊:Neuro-Oncology

影响因子:13.4

doi:10.1093/neuonc/noz145

Wirsching, Hans-Georg; Arora, Sonali; Zhang, Huajia; Szulzewsky, Frank; Cimino, Patrick J; Quéva, Christophe; Houghton, A McGarry; Glorioso, Joseph C; Weller, Michael; Holland, Eric C

Celebrating 25 years of Molecular Therapy

庆祝分子疗法诞生25周年

Biosafety and efficacy of Kv7 activating rdHSV-CA8∗ analgesic gene therapy for chronic pain via the intra-articular route in mice

Kv7激活rdHSV-CA8*镇痛基因疗法经关节内途径治疗小鼠慢性疼痛的生物安全性和有效性

Next-generation replication-defective HSV vectors for delivery of large DNA payloads

用于递送大分子DNA载荷的新一代复制缺陷型HSV载体

Viral and cellular insulators promote sustained HSV vector-mediated transgene expression in brain

病毒和细胞绝缘体促进脑内HSV载体介导的转基因持续表达

An oncolytic herpes simplex virus armed with IL-12 for treatment of preclinical glioblastoma

一种携带IL-12的溶瘤性单纯疱疹病毒用于治疗临床前胶质母细胞瘤

Durable tissue-specific transgene expression in newborn mice following intraperitoneal delivery of non-cytotoxic HSV vectors

腹腔注射非细胞毒性HSV载体后，新生小鼠体内可实现持久的组织特异性转基因表达

Genetic mutations in HSV-1 replication-defective vectors: Implications for their safety in gene therapy applications.

HSV-1复制缺陷载体中的基因突变：对其在基因治疗应用中安全性的影响。

rdHSV-CA8 non-opioid analgesic gene therapy decreases somatosensory neuronal excitability by activating Kv7 voltage-gated potassium channels

rdHSV-CA8非阿片类镇痛基因疗法通过激活Kv7电压门控钾通道降低体感神经元的兴奋性。

Evaluation of parameters for efficient purification and long-term storage of herpes simplex virus-based vectors

评估用于高效纯化和长期储存单纯疱疹病毒载体的参数

Cooperation of oncolytic virotherapy with VEGF-neutralizing antibody treatment in IDH wildtype glioblastoma depends on MMP9

在IDH野生型胶质母细胞瘤中，溶瘤病毒疗法与VEGF中和抗体治疗的协同作用依赖于MMP9。