日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Integrative Genomics Approach Identifies Glial Transcriptomic Dysregulation and Risk in the Cortex of Individuals With Alcohol Use Disorder

整合基因组学方法揭示酒精使用障碍患者皮层神经胶质细胞转录组失调及风险

Warden, Anna S; Salem, Nihal A; Brenner, Eric; Sutherland, Greg T; Stevens, Julia; Kapoor, Manav; Goate, Alison M; Mayfield, R Dayne

Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease

认知储备对显性遗传阿尔茨海默病患者症状出现年龄和认知衰退的影响

Llibre-Guerra, Jorge J; Lu, Ruijin; Clarens, Ma Florencia; Liu, Ian; Renton, Alan; Ryan, Natalie S; Goate, Alison M; Aguillón, David; Allegri, Ricardo Francisco; Benzinger, Tammie L S; Berman, Sarah; Chhatwal, Jasmeer P; Chrem Mendez, Patricio; Vigo, Gabriela; Cruchaga, Carlos; Day, Gregory S; Farlow, Martin R; Fox, Nick C; Gordon, Brian Andrew; Hassenstab, Jason; Huey, Edward D; Ibanez, Laura; Ikeuchi, Takeshi; Jucker, Mathias; Lee, Jae-Hong; Levey, Allan I; Levin, Johannes; Niimi, Yoshiki; Perrin, Richard J; Rosa-Neto, Pedro; Sánchez-Valle, Raquel; Schofield, Peter R; Wang, Guoqiao; Li, Yan; Xiong, Chengjie; Morris, John C; Karch, Celeste; Daniels, Alisha J; McDade, Eric; Bateman, Randall J

Uncovering NMDA receptor-mediated high firing activity in excitatory human neurons

揭示人类兴奋性神经元中NMDA受体介导的高放电活动

Gameiro-Ros, Isabel; Tengolics, Adam J; Prytkova, Iya; Kamarajan, Chella; Pang, Zhiping P; Goate, Alison M; Hart, Ronald P; Slesinger, Paul A

Reduced LACTB expression in myeloid cells is associated with elevated succinylcarnitine levels and reduced Alzheimers disease risk

髓系细胞中 LACTB 表达降低与琥珀酰肉碱水平升高和阿尔茨海默病风险降低相关。

Romero-Molina, Carmen; Gomez-Gutierrez, Ruben; See, Wen Yi; Patel, Tulsi; Davtyan, Hayk; Ma, Jiacheng; Xu, Quanyun; Sewell, Michael; Allton, Kendra; McReynolds, Morgan; Calderon, Olivia; Lightfoot, Yaima L; Bommer, Guido; Cruchaga, Carlos; Blurton-Jones, Mathew; Ray, William J; Marcora, Edoardo; Goate, Alison M

Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder

尾状核的整合单细胞多组学分析揭示了酒精使用障碍的关键机制

Green, Nicholas C; Gao, Hongyu; Chu, Xiaona; Yuan, Qiuyue; McGuire, Patrick; Lai, Dongbing; Jiang, Guanglong; Xuei, Xiaoling; Reiter, Jill L; Stevens, Julia; Sutherland, Greg T; Goate, Alison M; Pang, Zhiping P; Slesinger, Paul A; Hart, Ronald P; Tischfield, Jay A; Agrawal, Arpana; Wang, Yue; Duren, Zhana; Edenberg, Howard J; Liu, Yunlong

Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer's disease

阐明阿尔茨海默病抵抗力遗传结构的新型建模方法

Phillips, Jared M; Dumitrescu, Logan C; Archer, Derek B; Regelson, Alexandra N; Mukherjee, Shubhabrata; Lee, Michael L; Choi, Seo-Eun; Scollard, Phoebe; Trittschuh, Emily H; Kukull, Walter A; Biber, Sarah; Mez, Jesse; Mahoney, Emily R; Clifton, Michelle; Libby, Julia B; Walters, Skylar; Bush, William S; Engelman, Corinne D; Lu, Qiongshi; Fardo, David W; Widaman, Keith F; Buckley, Rachel F; Mormino, Elizabeth C; Sanders, R Elizabeth; Clark, Lindsay R; Gifford, Katherine A; Vardarajan, Badri; Cuccaro, Michael L; Pericak-Vance, Margaret A; Farrer, Lindsay A; Wang, Li-San; Schellenberg, Gerard D; Haines, Jonathan L; Jefferson, Angela L; Johnson, Sterling C; Albert, Marilyn S; Keene, C Dirk; Saykin, Andrew J; Risacher, Shannon L; Larson, Eric B; Sperling, Reisa A; Mayeux, Richard; Goate, Alison M; Renton, Alan E; Marcora, Edoardo; Fulton-Howard, Brian; Patel, Tulsi; Bennett, David A; Schneider, Julie A; Barnes, Lisa L; Cruchaga, Carlos; Hassenstab, Jason; Belloy, Michael E; Andrews, Shea J; Resnick, Susan M; Bilgel, Murat; An, Yang; Beason-Held, Lori L; Walker, Keenan A; Duggan, Michael R; Klinedinst, Brandon S; Crane, Paul K; Hohman, Timothy J

The landscape of autosomal-dominant Alzheimer's disease: global distribution and age of onset

常染色体显性遗传阿尔茨海默病概况:全球分布及发病年龄

Liu, Haiyan; Marsh, Thomas W; Shi, Xinyu; Renton, Alan E; Bowling, Kevin M; Ziegemeier, Ellen; Wang, Guoqiao; Cao, Yuchen; Aristel, Alisha; Li, Jessie; Dickson, Alexa; Perrin, Richard J; Goate, Alison M; Fernández, Victoria; Day, Gregory S; Doering, Michelle; Daniels, Alisha; Gordon, Brian A; Benzinger, Tammie L S; Hassenstab, Jason; Ibanez, Laura; Supnet-Bell, Charlene; Xiong, Chengjie; Allegri, Ricardo; Berman, Sarah B; Fox, Nick C; Ryan, Natalie S; Huey, Edward D; Vöglein, Jonathan; Noble, James M; Roh, Jee Hoon; Jucker, Mathias; Laske, Christoph; Ikeuchi, Takeshi; Sanchez-Valle, Raquel; Schofield, Peter R; Mendez, Patricio Chrem; Chhatwal, Jasmeer P; Farlow, Martin; Lee, Jae-Hong; Levey, Allan I; Levin, Johannes; Lopera, Francisco; Martins, Ralph; Niimi, Yoshiki; Rosa-Neto, Pedro; Morris, John C; Bateman, Randall J; Karch, Celeste M; Cruchaga, Carlos; McDade, Eric; Llibre-Guerra, Jorge J

Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease

一项包含56241名个体的多族裔全基因组荟萃分析,发现了已知的和新的跨人群及族裔特异性关联,这些关联被认为是阿尔茨海默病的新风险位点。

Rajabli, Farid; Benchek, Penelope; Tosto, Giuseppe; Kushch, Nicholas; Sha, Jin; Bazemore, Katrina; Zhu, Congcong; Lee, Wan-Ping; Haut, Jacob; Hamilton-Nelson, Kara L; Wheeler, Nicholas R; Zhao, Yi; Farrell, John J; Grunin, Michelle A; Leung, Yuk Yee; Kuksa, Pavel P; Li, Donghe; da Fonseca, Eder Lucio; Mez, Jesse B; Palmer, Ellen L; Pillai, Jagan; Sherva, Richard M; Song, Yeunjoo E; Zhang, Xiaoling; Ikeuchi, Takeshi; Iqbal, Taha; Pathak, Omkar; Valladares, Otto; Reyes-Dumeyer, Dolly; Kuzma, Amanda B; Abner, Erin; Adams, Larry D; Adams, Perrie M; Aguirre, Alyssa; Albert, Marilyn S; Albin, Roger L; Allen, Mariet; Alvarez, Lisa; Apostolova, Liana G; Arnold, Steven E; Asthana, Sanjay; Atwood, Craig S; Auerbach, Sanford; Ayres, Gayle; Baldwin, Clinton T; Barber, Robert C; Barnes, Lisa L; Barral, Sandra; Beach, Thomas G; Becker, James T; Beecham, Gary W; Beekly, Duane; Benitez, Bruno A; Bennett, David; Bertelson, John; Bird, Thomas D; Blacker, Deborah; Boeve, Bradley F; Bowen, James D; Boxer, Adam; Brewer, James; Burke, James R; Burns, Jeffrey M; Buxbaum, Joseph D; Cairns, Nigel J; Cantwell, Laura B; Cao, Chuanhai; Carlson, Christopher S; Carlsson, Cynthia M; Carney, Regina M; Carrasquillo, Minerva M; Chasse, Scott; Chesselet, Marie-Francoise; Chin, Nathaniel A; Chui, Helena C; Chung, Jaeyoon; Craft, Suzanne; Crane, Paul K; Cribbs, David H; Crocco, Elizabeth A; Cruchaga, Carlos; Cuccaro, Michael L; Cullum, Munro; Darby, Eveleen; Davis, Barbara; De Jager, Philip L; DeCarli, Charles; DeToledo, John; Dick, Malcolm; Dickson, Dennis W; Dombroski, Beth A; Doody, Rachelle S; Duara, Ranjan; Ertekin-Taner, NIlüfer; Evans, Denis A; Faber, Kelley M; Fairchild, Thomas J; Fallon, Kenneth B; Fardo, David W; Farlow, Martin R; Fernandez-Hernandez, Victoria; Ferris, Steven; Friedland, Robert P; Foroud, Tatiana M; Frosch, Matthew P; Fulton-Howard, Brian; Galasko, Douglas R; Gamboa, Adriana; Gearing, Marla; Geschwind, Daniel H; Ghetti, Bernardino; Gilbert, John R; Go, Rodney C P; Goate, Alison M; Grabowski, Thomas J; Graff-Radford, Neill R; Green, Robert C; Growdon, John H; Hakonarson, Hakon; Hall, James; Hamilton, Ronald L; Harari, Oscar; Hardy, John; Harrell, Lindy E; Head, Elizabeth; Henderson, Victor W; Hernandez, Michelle; Hohman, Timothy; Honig, Lawrence S; Huebinger, Ryan M; Huentelman, Matthew J; Hulette, Christine M; Hyman, Bradley T; Hynan, Linda S; Ibanez, Laura; Jarvik, Gail P; Jayadev, Suman; Jin, Lee-Way; Johnson, Kim; Johnson, Leigh; Kamboh, M Ilyas; Karydas, Anna M; Katz, Mindy J; Kauwe, John S; Kaye, Jeffrey A; Keene, C Dirk; Khaleeq, Aisha; Kikuchi, Masataka; Kim, Ronald; Knebl, Janice; Kowall, Neil W; Kramer, Joel H; Kukull, Walter A; LaFerla, Frank M; Lah, James J; Larson, Eric B; Lerner, Alan; Leverenz, James B; Levey, Allan I; Lieberman, Andrew P; Lipton, Richard B; Logue, Mark; Lopez, Oscar L; Lunetta, Kathryn L; Lyketsos, Constantine G; Mains, Douglas; Margaret, Flanagan E; Marson, Daniel C; Martin, Eden Rr; Martiniuk, Frank; Mash, Deborah C; Masliah, Eliezer; Massman, Paul; Masurkar, Arjun; McCormick, Wayne C; McCurry, Susan M; McDavid, Andrew N; McDonough, Stefan; McKee, Ann C; Mesulam, Marsel; Miller, Bruce L; Miller, Carol A; Miller, Joshua W; Montine, Thomas J; Monuki, Edwin S; Morris, John C; Mukherjee, Shubhabrata; Myers, Amanda J; Nguyen, Trung; Obisesan, Thomas; O'Bryant, Sid; Olichney, John M; Ory, Marcia; Palmer, Raymond; Parisi, Joseph E; Paulson, Henry L; Pavlik, Valory; Paydarfar, David; Perez, Victoria; Peskind, Elaine; Petersen, Ronald C; Petrovitch, Helen; Pierce, Aimee; Polk, Marsha; Poon, Wayne W; Potter, Huntington; Qu, Liming; Quiceno, Mary; Quinn, Joseph F; Raj, Ashok; Raskind, Murray; Reiman, Eric M; Reisberg, Barry; Reisch, Joan S; Ringman, John M; Roberson, Erik D; Rodriguear, Monica; Rogaeva, Ekaterina; Rosen, Howard J; Rosenberg, Roger N; Royall, Donald R; Sabbagh, Marwan; Sadovnick, A Dessa; Sager, Mark A; Sano, Mary; Saykin, Andrew J; Schneider, Julie A; Schneider, Lon S; Seeley, William W; Slifer, Susan H; Small, Scott; Smith, Amanda G; Smith, Janet P; Sonnen, Joshua A; Spina, Salvatore; George-Hyslop, Peter St; Starks, Takiyah D; Stern, Robert A; Stevens, Alan B; Strittmatter, Stephen M; Sultzer, David; Swerdlow, Russell H; Tanzi, Rudolph E; Tilson, Jeffrey L; Trojanowski, John Q; Troncoso, Juan C; Tsolaki, Magda; Tsuang, Debby W; Van Deerlin, Vivianna M; van Eldik, Linda J; Vance, Jeffery M; Vardarajan, Badri N; Vassar, Robert; Vinters, Harry V; Vonsattel, Jean-Paul; Weintraub, Sandra; Welsh-Bohmer, Kathleen A; Whitehead, Patrice L; Wijsman, Ellen M; Wilhelmsen, Kirk C; Williams, Benjamin; Williamson, Jennifer; Wilms, Henrik; Wingo, Thomas S; Wisniewski, Thomas; Woltjer, Randall L; Woon, Martin; Wright, Clinton B; Wu, Chuang-Kuo; Younkin, Steven G; Yu, Chang-En; Yu, Lei; Zhu, Xiongwei; Kunkle, Brian W; Bush, William S; Miyashita, Akinori; Byrd, Goldie S; Wang, Li-San; Farrer, Lindsay A; Haines, Jonathan L; Mayeux, Richard; Pericak-Vance, Margaret A; Schellenberg, Gerard D; Jun, Gyungah R; Reitz, Christiane; Naj, Adam C

Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells

17q21.31拷贝数变异和单倍型分析揭示了进行性核上性麻痹风险增加以及神经元细胞基因表达变化。

Wang, Hui; Chang, Timothy S; Dombroski, Beth A; Cheng, Po-Liang; Si, Ya-Qin; Tucci, Albert; Patil, Vishakha; Valiente-Banuet, Leopoldo; Li, Chong; Farrell, Kurt; Mclean, Catriona; Molina-Porcel, Laura; Rajput, Alex; De Deyn, Peter Paul; Le Bastard, Nathalie; Gearing, Marla; Donker Kaat, Laura; Van Swieten, John C; Dopper, Elise; Ghetti, Bernardino F; Newell, Kathy L; Troakes, Claire; de Yébenes, Justo G; Rábano-Gutierrez, Alberto; Meller, Tina; Oertel, Wolfgang H; Respondek, Gesine; Stamelou, Maria; Arzberger, Thomas; Roeber, Sigrun; Müller, Ulrich; Hopfner, Franziska; Pastor, Pau; Brice, Alexis; Durr, Alexandra; Le Ber, Isabelle; Beach, Thomas G; Serrano, Geidy E; Hazrati, Lili-Naz; Litvan, Irene; Rademakers, Rosa; Ross, Owen A; Galasko, Douglas; Boxer, Adam L; Miller, Bruce L; Seeley, Willian W; Van Deerlin, Vivianna M; Lee, Edward B; White, Charles L 3rd; Morris, Huw R; de Silva, Rohan; Crary, John F; Goate, Alison M; Friedman, Jeffrey S; Compta, Yaroslau; Leung, Yuk Yee; Coppola, Giovanni; Naj, Adam C; Wang, Li-San; Dalgard, Clifton; Dickson, Dennis W; Höglinger, Günter U; Tzeng, Jung-Ying; Geschwind, Daniel H; Schellenberg, Gerard D; Lee, Wan-Ping

Cytokine-induced reprogramming of human macrophages toward Alzheimer's disease-relevant molecular and cellular phenotypes in vitro

体外细胞因子诱导人巨噬细胞向阿尔茨海默病相关分子和细胞表型重编程

Podleśny-Drabiniok, Anna; Romero-Molina, Carmen; Patel, Tulsi; See, Wen Yi; Liu, Yiyuan; Marcora, Edoardo; Goate, Alison M