文献库，生知库 | 链接生命科学的每一步

Decreased Vector Gene Expression from E2b Gene-Deleted Adenovirus Serotype 5 Vaccines Intensifies Proinflammatory Immune Responses

E2b基因缺失的5型腺病毒疫苗导致载体基因表达降低，从而增强促炎性免疫反应。

期刊:Clinical and Vaccine Immunology

影响因子:

doi:10.1128/CVI.00061-17

Quiroga, Dionisia; Aldhamen, Yasser A; Godbehere, Sarah; Harding, Laura; Amalfitano, Andrea

In Vivo Synthesis of Cyclic-di-GMP Using a Recombinant Adenovirus Preferentially Improves Adaptive Immune Responses against Extracellular Antigens

利用重组腺病毒在体内合成环二鸟苷酸可优先增强针对细胞外抗原的适应性免疫反应

期刊:Journal of Immunology

影响因子:3.4

doi:10.4049/jimmunol.1501272

Alyaqoub, Fadel S; Aldhamen, Yasser A; Koestler, Benjamin J; Bruger, Eric L; Seregin, Sergey S; Pereira-Hicks, Cristiane; Godbehere, Sarah; Waters, Christopher M; Amalfitano, Andrea

Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells

自身免疫性疾病相关的细胞外内质网氨肽酶1变异体可诱导人类免疫细胞产生改变的先天免疫反应

期刊:Journal of Innate Immunity

影响因子:3

doi:10.1159/000368899

Aldhamen, Yasser A; Pepelyayeva, Yuliya; Rastall, David P W; Seregin, Sergey S; Zervoudi, Efthalia; Koumantou, Despoina; Aylsworth, Charles F; Quiroga, Dionisia; Godbehere, Sarah; Georgiadis, Dimitris; Stratikos, Efstratios; Amalfitano, Andrea

ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responses

ERAP1 的功能会抑制特定抗原作为免疫优势肽的内在选择，从而改变抗原特异性细胞毒性 T 细胞和效应记忆 T 细胞反应的效力。

期刊:International Immunology

影响因子:3.2

doi:10.1093/intimm/dxu078

Rastall, David P W; Aldhamen, Yasser A; Seregin, Sergey S; Godbehere, Sarah; Amalfitano, Andrea

Stimulation of innate immunity by in vivo cyclic di-GMP synthesis using adenovirus.

利用腺病毒在体内合成环状二鸟苷酸，从而刺激先天免疫

期刊:Clinical and Vaccine Immunology

影响因子:

doi:10.1128/CVI.00471-14

Koestler Benjamin J, Seregin Sergey S, Rastall David P W, Aldhamen Yasser A, Godbehere Sarah, Amalfitano Andrea, Waters Christopher M

免疫/内分泌

发表日期：2014

文献求助收藏

Use of DAF-displaying adenovirus vectors reduces induction of transgene- and vector-specific adaptive immune responses in mice

使用展示DAF的腺病毒载体可降低小鼠体内转基因和载体特异性适应性免疫反应的诱导。

期刊:Human Gene Therapy

影响因子:4

doi:10.1089/hum.2010.218

Seregin, Sergey S; Aldhamen, Yasser A; Appledorn, Daniel M; Zehnder, Jennifer; Voss, Tyler; Godbehere, Sarah; Amalfitano, Andrea

Vaccine platforms combining circumsporozoite protein and potent immune modulators, rEA or EAT-2, paradoxically result in opposing immune responses

将环子孢子蛋白与强效免疫调节剂（如rEA或EAT-2）相结合的疫苗平台，却会产生截然相反的免疫反应，这看似矛盾，实则不然。

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0024147

Schuldt, Nathaniel J; Aldhamen, Yasser A; Appledorn, Daniel M; Seregin, Sergey S; Kousa, Youssef; Godbehere, Sarah; Amalfitano, Andrea

免疫/内分泌

发表日期：2011

文献求助收藏

Sublingual administration of an adenovirus serotype 5 (Ad5)-based vaccine confirms Toll-like receptor agonist activity in the oral cavity and elicits improved mucosal and systemic cell-mediated responses against HIV antigens despite preexisting Ad5 immunity

舌下给药腺病毒5型（Ad5）疫苗证实了其在口腔内具有Toll样受体激动剂活性，并且即使在预先存在Ad5免疫的情况下，也能诱导针对HIV抗原的黏膜和全身细胞介导免疫反应增强。

期刊:Clinical and Vaccine Immunology

影响因子:

doi:10.1128/CVI.00341-10

Appledorn, Daniel M; Aldhamen, Yasser A; Godbehere, Sarah; Seregin, Sergey S; Amalfitano, Andrea

Novel adenovirus vectors 'capsid-displaying' a human complement inhibitor

新型腺病毒载体“衣壳展示”人补体抑制剂

期刊:Journal of Innate Immunity

影响因子:3

doi:10.1159/000284368

Seregin, Sergey S; Hartman, Zachary C; Appledorn, Daniel M; Godbehere, Sarah; Jiang, Haixiang; Frank, Michael M; Amalfitano, Andrea

ERAP1 is a critical regulator of inflammasome-mediated proinflammatory and ER stress responses

ERAP1是炎症小体介导的促炎反应和内质网应激反应的关键调节因子

Decreased Vector Gene Expression from E2b Gene-Deleted Adenovirus Serotype 5 Vaccines Intensifies Proinflammatory Immune Responses

E2b基因缺失的5型腺病毒疫苗导致载体基因表达降低，从而增强促炎性免疫反应。

In Vivo Synthesis of Cyclic-di-GMP Using a Recombinant Adenovirus Preferentially Improves Adaptive Immune Responses against Extracellular Antigens

利用重组腺病毒在体内合成环二鸟苷酸可优先增强针对细胞外抗原的适应性免疫反应

Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells

自身免疫性疾病相关的细胞外内质网氨肽酶1变异体可诱导人类免疫细胞产生改变的先天免疫反应

ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responses

ERAP1 的功能会抑制特定抗原作为免疫优势肽的内在选择，从而改变抗原特异性细胞毒性 T 细胞和效应记忆 T 细胞反应的效力。

Stimulation of innate immunity by in vivo cyclic di-GMP synthesis using adenovirus.

利用腺病毒在体内合成环状二鸟苷酸，从而刺激先天免疫

Use of DAF-displaying adenovirus vectors reduces induction of transgene- and vector-specific adaptive immune responses in mice

使用展示DAF的腺病毒载体可降低小鼠体内转基因和载体特异性适应性免疫反应的诱导。

Vaccine platforms combining circumsporozoite protein and potent immune modulators, rEA or EAT-2, paradoxically result in opposing immune responses

将环子孢子蛋白与强效免疫调节剂（如rEA或EAT-2）相结合的疫苗平台，却会产生截然相反的免疫反应，这看似矛盾，实则不然。

Sublingual administration of an adenovirus serotype 5 (Ad5)-based vaccine confirms Toll-like receptor agonist activity in the oral cavity and elicits improved mucosal and systemic cell-mediated responses against HIV antigens despite preexisting Ad5 immunity

舌下给药腺病毒5型（Ad5）疫苗证实了其在口腔内具有Toll样受体激动剂活性，并且即使在预先存在Ad5免疫的情况下，也能诱导针对HIV抗原的黏膜和全身细胞介导免疫反应增强。

Novel adenovirus vectors 'capsid-displaying' a human complement inhibitor

新型腺病毒载体“衣壳展示”人补体抑制剂