日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Quantify unmet medical need across the disease landscape - A large language model-based methodology

量化疾病领域中未满足的医疗需求——一种基于大型语言模型的方法

Sharp, Elliott W; Fragola, Nicholas; Blewitt, Charlotte; Goddeeris, Matthew; Lancashire, Lee; Hempstead, Charlie; Fajgenbaum, David C

A large-scale human toxicogenomics resource for drug-induced liver injury prediction

用于预测药物性肝损伤的大规模人类毒理基因组学资源

Bergen, Volker; Kodella, Konstantia; Srikrishnan, Sreenath; Barrandon, Ornella; Anderson, Sara; Rogers-Grazado, Max; Fowler, Casey; Beyene, Hirit; Robichaud, Nicole; Fulton, Timothy; Lapchyk, Nina; Cortes, Mauricio; Plugis, Nick; Goddeeris, Matthew; Zamanighomi, Mahdi

Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan

肌膜恢复力和骨骼肌健康需要肌营养不良蛋白聚糖的 O-甘露糖基化

Jeffrey M Hord, Sarah Burns, Tobias Willer, Matthew M Goddeeris, David Venzke, Kevin P Campbell

Genetics of cystogenesis in base-edited human organoids reveal therapeutic strategies for polycystic kidney disease

碱基编辑的人类类器官中囊肿形成的遗传学揭示了多囊肾病的治疗策略

Courtney E Vishy, Chardai Thomas, Thomas Vincent, Daniel K Crawford, Matthew M Goddeeris, Benjamin S Freedman

Targeting G542X CFTR nonsense alleles with ELX-02 restores CFTR function in human-derived intestinal organoids

利用 ELX-02 靶向 G542X CFTR 无义等位基因可恢复人源肠道类器官中的 CFTR 功能

Daniel K Crawford, Jasper Mullenders, Johanna Pott, Sylvia F Boj, Shira Landskroner-Eiger, Matthew M Goddeeris

ELX-02 Generates Protein via Premature Stop Codon Read-Through without Inducing Native Stop Codon Read-Through Proteins

ELX-02 通过提前终止密码子读通生成蛋白质,而不会诱导天然终止密码子读通蛋白质

Daniel K Crawford, Iris Alroy, Neal Sharpe, Matthew M Goddeeris, Greg Williams

PPARδ modulation rescues mitochondrial fatty acid oxidation defects in the mdx model of muscular dystrophy

PPARδ 调节可挽救肌营养不良症 mdx 模型中的线粒体脂肪酸氧化缺陷

Eric L Bell, Robert W Shine, Peter Dwyer, Lyndsay Olson, Jennifer Truong, Ross Fredenburg, Matthew Goddeeris, Dominique Stickens, Effie Tozzo

Histopathological lesions in reproductive organs, distal spinal cord and peripheral nerves of horses naturally infected with Trypanosoma equiperdum

自然感染马锥虫的马的生殖器官、远端脊髓和周围神经的组织病理学病变

Yasine, Ahmed; Ashenafi, Hagos; Geldhof, Peter; Van Brantegem, Leen; Vercauteren, Griet; Bekana, Merga; Tola, Alemu; Van Soom, Ann; Duchateau, Luc; Goddeeris, Bruno; Govaere, Jan

Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD)

选择性PPARδ调节剂改善线粒体功能:杜氏肌营养不良症(DMD)的潜在治疗方法

Lagu, Bharat; Kluge, Arthur F; Tozzo, Effie; Fredenburg, Ross; Bell, Eric L; Goddeeris, Matthew M; Dwyer, Peter; Basinski, Andrew; Senaiar, Ramesh S; Jaleel, Mahaboobi; Tiwari, Nirbhay Kumar; Panigrahi, Sunil K; Krishnamurthy, Narasimha Rao; Takahashi, Taisuke; Patane, Michael A

Prevalence and antimicrobial susceptibility of Escherichia coli O157 in beef at butcher shops and restaurants in central Ethiopia

埃塞俄比亚中部肉店和餐馆牛肉中大肠杆菌O157的流行情况及抗菌药物敏感性

Beyi, Ashenafi Feyisa; Fite, Akafete Teklu; Tora, Ephrem; Tafese, Asdesach; Genu, Tadele; Kaba, Tamirat; Beyene, Tariku Jibat; Beyene, Takele; Korsa, Mesula Geloye; Tadesse, Fanos; De Zutter, Lieven; Goddeeris, Bruno Maria; Cox, Eric