日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Repositioning a Human Kinase Platelet-Derived Growth Factor Receptor Alpha Type II Inhibitor for Malaria and Inhibition of Hemozoin Formation

将人激酶血小板衍生生长因子受体α II型抑制剂重新定位用于疟疾和抑制血红素晶体形成

Mmonwa, Mmakwena M; Audu, Oluwatosin; Maepa, Keletso; Dziwornu, Godwin A; Govender, Preshen; Tshaka, Liso; Burrows, James; Taylor, Dale; Masike, Keabetswe; Njoroge, Mathew; Wicht, Kathryn J; Coulson, Lauren B; Chibale, Kelly

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

ATM激酶抑制剂AZD0156是疟原虫磷脂酰肌醇4-激酶(PI4Kβ)的强效抑制剂,是抗疟药物化学优化的理想候选药物。

Woodland, John G; Coertzen, Dina; Wicht, Kathryn J; Hidalgo, Virginia Franco; Pasaje, Charisse Flerida A; Godoy, Luiz C; Qahash, Tarrick; Mmonwa, Mmakwena M; Dziwornu, Godwin A; Wambua, Lynn; Harries, Sarah; Korkor, Constance M; Njoroge, Mathew; Krugmann, Liezl; Taylor, Dale; Leshabane, Meta; Langeveld, Henrico; Rabie, Tayla; Reader, Janette; van der Watt, Mariëtte; Venter, Nelius; Erlank, Erica; Aswat, Ayesha S; Koekemoer, Lizette L; Yeo, Tomas; Jeon, Jin H; Fidock, David A; Gamo, Francisco Javier; Wittlin, Sergio; Niles, Jacquin C; Llinas, Manuel; Coulson, Lauren B; Birkholtz, Lyn-Marié; Chibale, Kelly

Functional Mapping of Key Residues in Reductive Aminases Enabled by a High-Throughput RedAm Detect Assay

利用高通量 RedAm Detect 检测方法对还原性氨酶中的关键残基进行功能定位

Xing, Jinming; Orderley, Georgie; Bradshaw Allen, Ruth T; Ahmad, Nabieha N; Gourjault, Camille; Akgul, Ardil; Alhassan, Sephia O; Ngernanek, Nichapa; Salke, Siddhika; Aleku, Godwin A

Optimization of 2,8-Diaryl-1,5-naphthyridines as Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy

优化 2,8-二芳基-1,5-萘啶类化合物作为恶性疟原虫磷脂酰肌醇 4-激酶抑制剂,以改善其 ADME 特性和体内疗效

Dziwornu, Godwin A; Seanego, Donald; Fienberg, Stephen; Sypu, Venkata S; Salomane, Nicolaas; Krugmann, Liezl; Taylor, Dale; Masike, Keabetswe; Njoroge, Mathew; Boonyalai, Nonlawat; Lee, Marcus C S; Godoy, Luiz C; Pasaje, Charisse Flerida; Niles, Jacquin C; Basarab, Gregory S; Coulson, Lauren B; Ghorpade, Sandeep R; Chibale, Kelly

New Generation Modified Azole Antifungals against Multidrug-Resistant Candida auris

新一代改良唑类抗真菌药物对抗耐多药耳念珠菌

Chen, Yiyuan; Li, Yunxiao; Nahar, Kazi S; Hasan, Md Mahbub; Marsh, Caleb; Clifford, Melanie; Aleku, Godwin A; Kelly, Steven L; Lamb, David C; Mpamhanga, Chengetai Diana; Kounatidis, Ilias; Shah, Ajit J; Hind, Charlotte K; Sutton, J Mark; Rahman, Khondaker Miraz

A Review of the Valorization of Dairy Industry Wastes through Thermochemical, Biological, and Integrated Processes for Value-Added Products

通过热化学、生物和集成工艺对乳制品工业废弃物进行增值利用,生产高附加值产品的研究综述

Udourioh, Godwin A; Solomon, Moses M; Okolie, Jude A

Expanding the repertoire of imine reductases by mining divergent biosynthetic pathways for promiscuous reactivity

通过挖掘不同的生物合成途径来扩展亚胺还原酶的底物选择性反应能力

Aleku, Godwin A; Hollfelder, Florian

Inhaled Ivermectin-Loaded Lipid Polymer Hybrid Nanoparticles: Development and Characterization

吸入式伊维菌素负载脂质聚合物杂化纳米颗粒:开发与表征

Kassaee, Seyedeh Negin; Ayoko, Godwin A; Richard, Derek; Wang, Tony; Islam, Nazrul

Lipid polymer hybrid nanoparticles against lung cancer and their application as inhalable formulation

脂质聚合物杂化纳米粒子抗肺癌及其在吸入制剂中的应用

Kassaee, Seyedeh Negin; Richard, Derek; Ayoko, Godwin A; Islam, Nazrul

Antimicrobial and in silico studies of the triterpenoids of Dichapetalum albidum

白花楸三萜类化合物的抗菌活性及计算机模拟研究

Chama, Mary A; Dziwornu, Godwin A; Popli, Elizabeth; Mas-Claret, Eduard; Egyir, Beverly; Ayine-Tora, Daniel M; Owusu, Kofi B-A; Reid, David G; Osei-Safo, Dorcas; Duer, Melinda; Mulholland, Dulcie; Bender, Andreas