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Targeting both tumour-associated CXCR2(+) neutrophils and CCR2(+) macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma

靶向肿瘤相关CXCR2(+)中性粒细胞和CCR2(+)巨噬细胞可破坏髓系细胞募集，并改善胰腺导管腺癌的化疗反应。

doi:10.1136/gutjnl-2017-313738

Nywening, Timothy M; Belt, Brian A; Cullinan, Darren R; Panni, Roheena Z; Han, Booyeon J; Sanford, Dominic E; Jacobs, Ryan C; Ye, Jian; Patel, Ankit A; Gillanders, William E; Fields, Ryan C; DeNardo, David G; Hawkins, William G; Goedegebuure, Peter; Linehan, David C

Mammaglobin-A is a target for breast cancer vaccination

乳球蛋白A是乳腺癌疫苗的靶点。

期刊:Oncoimmunology

影响因子:6.3

doi:10.1080/2162402X.2015.1069940

Kim, Samuel W; Goedegebuure, Peter; Gillanders, William E

Safety and preliminary evidence of biologic efficacy of a mammaglobin-a DNA vaccine in patients with stable metastatic breast cancer

乳球蛋白-a DNA疫苗在稳定期转移性乳腺癌患者中的安全性和初步生物学疗效证据

期刊:Clinical Cancer Research

影响因子:10.2

doi:10.1158/1078-0432.CCR-14-0059

Tiriveedhi, Venkataswarup; Tucker, Natalia; Herndon, John; Li, Lijin; Sturmoski, Mark; Ellis, Matthew; Ma, Cynthia; Naughton, Michael; Lockhart, A Craig; Gao, Feng; Fleming, Timothy; Goedegebuure, Peter; Mohanakumar, Thalachallour; Gillanders, William E

Mammaglobin-A cDNA vaccination of breast cancer patients induces antigen-specific cytotoxic CD4+ICOShi T cells

乳腺癌患者接种乳球蛋白A cDNA疫苗可诱导抗原特异性细胞毒性CD4+ICOShi T细胞

期刊:Breast Cancer Research and Treatment

影响因子:3

doi:10.1007/s10549-012-2110-9

Tiriveedhi, Venkataswarup; Fleming, Timothy P; Goedegebuure, Peter S; Naughton, Michael; Ma, Cynthia; Lockhart, Craig; Gao, Feng; Gillanders, William E; Mohanakumar, T

A phase I study of IMP321 and gemcitabine as the front-line therapy in patients with advanced pancreatic adenocarcinoma

一项 IMP321 联合吉西他滨作为晚期胰腺腺癌患者一线治疗的 I 期研究

期刊:Investigational New Drugs

影响因子:2.7

doi:10.1007/s10637-012-9866-y

Wang-Gillam, Andrea; Plambeck-Suess, Stacey; Goedegebuure, Peter; Simon, Peter O; Mitchem, Jonathan B; Hornick, John R; Sorscher, Steven; Picus, Joel; Suresh, Rama; Lockhart, Albert C; Tan, Benjamin; Hawkins, Williams G

Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer.

溶酶体膜通透性是胰腺癌中 Sigma-2 受体配体介导的细胞死亡的早期事件

期刊:Journal of Experimental & Clinical Cancer Research

影响因子:12.8

doi:10.1186/1756-9966-31-41

Hornick John R, Vangveravong Suwanna, Spitzer Dirk, Abate Carmen, Berardi Francesco, Goedegebuure Peter, Mach Robert H, Hawkins William G

Cross-dressed CD8α+/CD103+ dendritic cells prime CD8+ T cells following vaccination

疫苗接种后，交叉着装的CD8α+/CD103+树突状细胞可启动CD8+ T细胞。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.1203468109

Li, Lijin; Kim, Sojung; Herndon, John M; Goedegebuure, Peter; Belt, Brian A; Satpathy, Ansuman T; Fleming, Timothy P; Hansen, Ted H; Murphy, Kenneth M; Gillanders, William E

Regulating mammalian target of rapamycin to tune vaccination-induced CD8(+) T cell responses for tumor immunity

调控哺乳动物雷帕霉素靶蛋白以调节疫苗诱导的CD8(+) T细胞反应，从而增强肿瘤免疫力

期刊:Journal of Immunology

影响因子:3.4

doi:10.4049/jimmunol.1103365

Li, Qingsheng; Rao, Rajesh; Vazzana, Joseph; Goedegebuure, Peter; Odunsi, Kunle; Gillanders, William; Shrikant, Protul A

Therapeutic targeting of pancreatic cancer utilizing sigma-2 ligands

利用σ-2配体进行胰腺癌的靶向治疗

期刊:Surgery

影响因子:2.7

doi:10.1016/j.surg.2012.05.014

Hornick, John R; Spitzer, Dirk; Goedegebuure, Peter; Mach, Robert H; Hawkins, William G

Understanding and addressing barriers to successful adenovirus-based virotherapy for ovarian cancer

了解并解决基于腺病毒的卵巢癌病毒疗法成功实施的障碍

Targeting both tumour-associated CXCR2(+) neutrophils and CCR2(+) macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma

靶向肿瘤相关CXCR2(+)中性粒细胞和CCR2(+)巨噬细胞可破坏髓系细胞募集，并改善胰腺导管腺癌的化疗反应。

Mammaglobin-A is a target for breast cancer vaccination

乳球蛋白A是乳腺癌疫苗的靶点。

Safety and preliminary evidence of biologic efficacy of a mammaglobin-a DNA vaccine in patients with stable metastatic breast cancer

乳球蛋白-a DNA疫苗在稳定期转移性乳腺癌患者中的安全性和初步生物学疗效证据

Mammaglobin-A cDNA vaccination of breast cancer patients induces antigen-specific cytotoxic CD4+ICOShi T cells

乳腺癌患者接种乳球蛋白A cDNA疫苗可诱导抗原特异性细胞毒性CD4+ICOShi T细胞

A phase I study of IMP321 and gemcitabine as the front-line therapy in patients with advanced pancreatic adenocarcinoma

一项 IMP321 联合吉西他滨作为晚期胰腺腺癌患者一线治疗的 I 期研究

Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer.

溶酶体膜通透性是胰腺癌中 Sigma-2 受体配体介导的细胞死亡的早期事件

Cross-dressed CD8α+/CD103+ dendritic cells prime CD8+ T cells following vaccination

疫苗接种后，交叉着装的CD8α+/CD103+树突状细胞可启动CD8+ T细胞。

Regulating mammalian target of rapamycin to tune vaccination-induced CD8(+) T cell responses for tumor immunity

调控哺乳动物雷帕霉素靶蛋白以调节疫苗诱导的CD8(+) T细胞反应，从而增强肿瘤免疫力

Therapeutic targeting of pancreatic cancer utilizing sigma-2 ligands

利用σ-2配体进行胰腺癌的靶向治疗