日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Distinct tau filament folds in human MAPT mutants P301L and P301T

人类MAPT突变体P301L和P301T中tau蛋白丝的独特折叠

Schweighauser, Manuel; Shi, Yang; Murzin, Alexey G; Garringer, Holly J; Vidal, Ruben; Murrell, Jill R; Erro, M Elena; Seelaar, Harro; Ferrer, Isidro; van Swieten, John C; Ghetti, Bernardino; Scheres, Sjors H W; Goedert, Michel

Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W

人类 MAPT 突变体 V337M 和 R406W 中具有阿尔茨海默病折叠的 Tau 丝

Qi, Chao; Lövestam, Sofia; Murzin, Alexey G; Peak-Chew, Sew; Franco, Catarina; Bogdani, Marika; Latimer, Caitlin; Murrell, Jill R; Cullinane, Patrick W; Jaunmuktane, Zane; Bird, Thomas D; Ghetti, Bernardino; Scheres, Sjors H W; Goedert, Michel

Seeding biosensor cell line that reproduces the Alzheimer tau fold.

建立能够重现阿尔茨海默病 tau 折叠的生物传感器细胞系。

Katsinelos Taxiarchis, Lövestam Sofia, Qi Chao, Ryskeldi-Falcon Benjamin, Macdonald Jennifer A, Stephenson Gabriel, Ghetti Bernardino, McKee Ann, Scheres Sjors H W, Goedert Michel

Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G

在伴有VCP基因突变D395G的空泡性tau蛋白病病例中,tau蛋白丝与慢性创伤性脑病褶皱相连。

Qi, Chao; Kobayashi, Ryota; Kawakatsu, Shinobu; Kametani, Fuyuki; Scheres, Sjors H W; Goedert, Michel; Hasegawa, Masato

Correction: Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems

更正:裂解的TMEM106B在中枢和周围神经系统中形成淀粉样蛋白聚集体。

Bacioglu, Mehtap; Schweighauser, Manuel; Gray, Derrick; Lövestam, Sofia; Katsinelos, Taxiarchis; Quaegebeur, Annelies; van Swieten, John; Jaunmuktane, Zane; Davies, Stephen W; Scheres, Sjors H W; Goedert, Michel; Ghetti, Bernardino; Spillantini, Maria Grazia

Deciphering the pathological significance of self‐propagating Aβ strains in different animal models

解析不同动物模型中自我复制型Aβ菌株的病理学意义

Hashimoto, Y; Niikura, T; Ito, Y; Sudo, H; Hata, M; Arakawa, E; Abe, Y; Kita, Y; Nishimoto, I; Goedert, Michel; Goedert, Michel; Morales, Rodrigo

Tau and neurodegeneration

Tau蛋白与神经退行性疾病

Goedert, Michel; Crowther, R Anthony; Scheres, Sjors H W; Spillantini, Maria Grazia

Tau filaments with the Alzheimer fold in cases with MAPT mutations V337M and R406W

在MAPT基因V337M和R406W突变病例中,tau蛋白丝具有阿尔茨海默病折叠特征。

Qi, Chao; Lövestam, Sofia; Murzin, Alexey G; Peak-Chew, Sew; Franco, Catarina; Bogdani, Marika; Latimer, Caitlin; Murrell, Jill R; Cullinane, Patrick W; Jaunmuktane, Zane; Bird, Thomas D; Ghetti, Bernardino; Scheres, Sjors H W; Goedert, Michel

Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains

阿尔茨海默病患者脑组织水提取物超速离心上清液中含有大量Aβ纤维

Stern, Andrew M; Yang, Yang; Jin, Shanxue; Yamashita, Keitaro; Meunier, Angela L; Liu, Wen; Cai, Yuqi; Ericsson, Maria; Liu, Lei; Goedert, Michel; Scheres, Sjors H W; Selkoe, Dennis J

Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains

人脑和鼠脑中具有北极突变(E22G)的β-淀粉样蛋白丝的冷冻电镜结构

Yang, Yang; Zhang, Wenjuan; Murzin, Alexey G; Schweighauser, Manuel; Huang, Melissa; Lövestam, Sofia; Peak-Chew, Sew Y; Saito, Takashi; Saido, Takaomi C; Macdonald, Jennifer; Lavenir, Isabelle; Ghetti, Bernardino; Graff, Caroline; Kumar, Amit; Nordberg, Agneta; Goedert, Michel; Scheres, Sjors H W