日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

High-throughput mapping of 6,888 RAD51D variants identifies distinct biochemical functions needed for homologous recombination and olaparib response

对 6,888 个 RAD51D 变体进行高通量测序,鉴定出同源重组和奥拉帕尼反应所需的不同生化功能。

Darrah, Kristie E; Hemker, Shelby L; Rawal, Yashpal; Goff, Noah J; Parker, Phoebe; Ganesan, Gayatri; Stratton, Caleb M; Oppenheimer, Katherine; Roberts, Ella; Glick, Elena; Banks, Nicole; Kumar, Arjun; Casadei, Silvia; Snyder, Matthew W; Nathanson, Katherine; Domchek, Susan M; Starita, Lea M; Olsen, Shaun K; Sung, Patrick; Kitzman, Jacob O; Bernstein, Kara A

Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells.

单分子成像揭示了活细胞中非同源末端连接的动力学

Mikhova Mariia, Goff Noah J, Janovič Tomáš, Heyza Joshua R, Meek Katheryn, Schmidt Jens C

DNA-PK: A synopsis beyond synapsis

DNA-PK:超越突触的概要

Goff, Noah J; Mikhova, Mariia; Schmidt, Jens C; Meek, Katheryn

Compared to other NHEJ factors, DNA-PK protein and RNA levels are markedly increased in all higher primates, but not in prosimians or other mammals

与其他NHEJ因子相比,DNA-PK蛋白和RNA水平在所有高等灵长类动物中均显著升高,但在原猴或其他哺乳动物中则没有升高。

Pascarella, Giovanni; Conner, Kayla N; Goff, Noah J; Carninci, Piero; Olive, Andrew J; Meek, Katheryn

Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining.

两种不同的长程突触复合物促进DNA断裂通过非同源末端连接修复之前末端加工的不同方面

Buehl Christopher J, Goff Noah J, Hardwick Steven W, Gellert Martin, Blundell Tom L, Yang Wei, Chaplin Amanda K, Meek Katheryn

Unravelling the complexities of DNA-PK activation by structure-based mutagenesis

通过基于结构的诱变揭示DNA-PK激活的复杂性

Buehl, Christopher J; Goff, Noah J; Mikhova, Mariia; Hardwick, Steven W; Blundell, Thomas L; Modesti, Mauro; Schmidt, Jens C; Chaplin, Amanda; Meek, Katheryn