Binding of small molecules at the P-stalk site of ricin A subunit trigger conformational changes that extend into the active site.
小分子与蓖麻毒素 A 亚基 P 茎位点的结合会引发构象变化,进而延伸至活性位点
期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.108310
McLaughlin John E, Rudolph Michael J, Dutta Arkajyoti, Li Xiao-Ping, Tsymbal Anastasiia M, Chen Yang, Bhattacharya Shibani, Algava Benjamin, Goger Michael, Roberge Jacques Y, Tumer Nilgun E