日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fragment-Based Development of NSP14 Exonuclease Inhibitors Confounded by Batch-to-Batch Variability

基于片段的NSP14核酸外切酶抑制剂开发受批次间差异的影响

Coker, Jesse A; Sun, Rong; Polzer, Paul M; Romigh, Todd; Goins, Christopher M; Wang, Nancy S; Jung, Jae U; Stauffer, Shaun R

Dysregulation of innate immunity and cellular metabolism through virus-induced deISGylation

病毒诱导的去ISG化导致先天免疫和细胞代谢失调

Zhu, Junji; Liu, GuanQun; Xu, Jielin; Li, Kun; Goins, Christopher M; Yu, Huaxu; Sayyad, Zuberwasim; Zhou, Yadi; White, Evangeline; Fiehn, Oliver; Stauffer, Shaun R; Cheng, Feixiong; Gack, Michaela U

Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer.

肾癌中 SLC1A1/EAAT3 选择性抑制剂的机制和结构导向优化

Koochaki Pooneh, Qiu Biao, Coker Jesse A, Earsley Alexander, Wang Nancy S, Romigh Todd, Goins Christopher M, Stauffer Shaun R, Boudker Olga, Chakraborty Abhishek A

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

WDR5 是胶质母细胞瘤中癌症干细胞的一种具有治疗潜力的靶点。

Mitchell, Kelly; Sprowls, Samuel A; Arora, Sonali; Shakya, Sajina; Silver, Daniel J; Goins, Christopher M; Wallace, Lisa; Roversi, Gustavo; Schafer, Rachel E; Kay, Kristen; Miller, Tyler E; Lauko, Adam; Bassett, John; Kashyap, Anjali; D'Amato Kass, Jonathan; Mulkearns-Hubert, Erin E; Johnson, Sadie; Alvarado, Joseph; Rich, Jeremy N; Holland, Eric C; Paddison, Patrick J; Patel, Anoop P; Stauffer, Shaun R; Hubert, Christopher G; Lathia, Justin D

SARS-CoV-2 3CL-protease inhibitors derived from ML300: investigation of P1 and replacements of the 1,2,3-benzotriazole

源自ML300的SARS-CoV-2 3CL蛋白酶抑制剂:P1的研究及1,2,3-苯并三唑的替代

Hooper, Alice; Macdonald, Jonathan D; Reilly, Brenna; Maw, Joshua; Wirrick, Aidan P; Han, Sang Hoon; Lindsey, A Abigail; Rico, Emma G; Romigh, Todd; Goins, Christopher M; Wang, Nancy S; Stauffer, Shaun

Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL(pro))

基于结构的ML300衍生非共价抑制剂靶向严重急性呼吸综合征冠状病毒3CL蛋白酶(SARS-CoV-2 3CL(pro))的优化

Han, Sang Hoon; Goins, Christopher M; Arya, Tarun; Shin, Woo-Jin; Maw, Joshua; Hooper, Alice; Sonawane, Dhiraj P; Porter, Matthew R; Bannister, Breyanne E; Crouch, Rachel D; Lindsey, A Abigail; Lakatos, Gabriella; Martinez, Steven R; Alvarado, Joseph; Akers, Wendell S; Wang, Nancy S; Jung, Jae U; Macdonald, Jonathan D; Stauffer, Shaun R

Mycolyltransferase from Mycobacterium tuberculosis in covalent complex with tetrahydrolipstatin provides insights into antigen 85 catalysis

结核分枝杆菌的霉菌酰转移酶与四氢脂抑素形成共价复合物,为抗原85催化提供了新的见解

Goins, Christopher M; Dajnowicz, Steven; Smith, Micholas D; Parks, Jerry M; Ronning, Donald R

Exploring Covalent Allosteric Inhibition of Antigen 85C from Mycobacterium tuberculosis by Ebselen Derivatives

利用依布硒啉衍生物探索结核分枝杆菌抗原85C的共价变构抑制作用

Goins, Christopher M; Dajnowicz, Steven; Thanna, Sandeep; Sucheck, Steven J; Parks, Jerry M; Ronning, Donald R