日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Role of Human DNA Ligases in Mediating Pharmacological Activities of Flavonoids

人类DNA连接酶在介导黄酮类化合物药理活性中的作用

Sun, Daekyu; Gokhale, Vijay

Dyr726, a brain-penetrant inhibitor of PI3Kα, Type III receptor tyrosine kinases, and WNT signaling.

Dyr726 是一种可穿透血脑屏障的 PI3Kα、III 型受体酪氨酸激酶和 WNT 信号通路抑制剂

Tandon Vasudha, Fistrovich Alessandra, Nogales Joaquina, Ferro Febe, Rokey Samantha N, Cabel Carly, Miller Amy Dunne, Yagel Mary, Duncan Christina, Atmasidha Aditi, Sharma Ira, Wilms Gerrit, Williams Karin, Elliott Richard, Chavez Timothy, Shaw Yeng, McMahon Aidan, Ginn Sean, Basantes L Emilia, Bedard Nathan, Gokhale Vijay, Ellis Nathan, Prescott Alan R, Smith Stuart J, Rahman Ruman, Becker Walter, Read Kevin D, Chalmers Anthony J, Carragher Neil, Masson Glenn R, Montfort William, Thorne Curtis, Hulme Christopher, Banerjee Sourav

CNS‐active drugs for neuropsychiatric disorders differentially modulate the risk of AD development

用于治疗神经精神疾病的中枢神经系统活性药物对阿尔茨海默病(AD)的发生风险具有不同的调节作用。

Cai, Song; Moutal, Aubin; Yu, Jie; Chew, Lindsey A; Isensee, Jörg; Chawla, Reena; Gomez, Kimberly; Luo, Shizhen; Zhou, Yuan; Chefdeville, Aude; Madura, Cynthia; Perez-Miller, Samantha; Bellampalli, Shreya Sai; Dorame, Angie; Scott, David D; François-Moutal, Liberty; Shan, Zhiming; Woodward, Taylor; Gokhale, Vijay; Hohmann, Andrea G; Vanderah, Todd W; Patek, Marcel; Khanna, May; Hucho, Tim; Khanna, Rajesh; Cortes‐Flores, Helena; Torrandell‐Haro, Georgina; Brinton, Roberta Diaz

Quindoline-derivatives display potent G-quadruplex-mediated antiviral activity against herpes simplex virus 1

喹啉衍生物对单纯疱疹病毒1型表现出强效的G-四链体介导的抗病毒活性

Frasson, Ilaria; Soldà, Paola; Nadai, Matteo; Tassinari, Martina; Scalabrin, Matteo; Gokhale, Vijay; Hurley, Laurence H; Richter, Sara N

An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties

一种靶向TDP-43 N端结构域的RNA结合变构调节剂具有神经保护作用

Mollasalehi, Niloufar; Francois-Moutal, Liberty; Scott, David D; Tello, Judith A; Williams, Haley; Mahoney, Brendan; Carlson, Jacob M; Dong, Yue; Li, Xingli; Miranda, Victor G; Gokhale, Vijay; Wang, Wei; Barmada, Sami J; Khanna, May

Erratum: Nucleolin represses transcription of the androgen receptor gene through a G-quadruplex

更正:核仁蛋白通过G-四链体抑制雄激素受体基因的转录。

Miranti, Cindy K; Moore, Sara; Kim, Yongeun; Chappeta, Venkateshwar Reddy; Wu, Kui; De, Biswanath; Gokhale, Vijay; Hurley, Laurence H; Reyes-Reyes, Elsa M

Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)

靶向TDP-43 RNA识别基序的小分子可减轻果蝇肌萎缩侧索硬化症(ALS)模型中的运动缺陷

François-Moutal, Liberty; Felemban, Razaz; Scott, David D; Sayegh, Melissa R; Miranda, Victor G; Perez-Miller, Samantha; Khanna, Rajesh; Gokhale, Vijay; Zarnescu, Daniela C; Khanna, May

Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X

特定的G-四链体配体调节Bcl-X的替代剪接

Weldon, Carika; Dacanay, Justine G; Gokhale, Vijay; Boddupally, Peda Venkat L; Behm-Ansmant, Isabelle; Burley, Glenn A; Branlant, Christiane; Hurley, Laurence H; Dominguez, Cyril; Eperon, Ian C

A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B)

利用化学生物学方法构建脑桥小脑发育不全1B型(PCH1B)模型

François-Moutal, Liberty; Jahanbakhsh, Shahriyar; Nelson, Andrew D L; Ray, Debashish; Scott, David D; Hennefarth, Matthew R; Moutal, Aubin; Perez-Miller, Samantha; Ambrose, Andrew J; Al-Shamari, Ahmed; Coursodon, Philippe; Meechoovet, Bessie; Reiman, Rebecca; Lyons, Eric; Beilstein, Mark; Chapman, Eli; Morris, Quaid D; Van Keuren-Jensen, Kendall; Hughes, Timothy R; Khanna, Rajesh; Koehler, Carla; Jen, Joanna; Gokhale, Vijay; Khanna, May

Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels

Ubc9-CRMP2界面化学位移扰动映射揭示了CRMP2中一个适于Nav1.7通道变构调节的口袋。

François-Moutal, Liberty; Scott, David Donald; Perez-Miller, Samantha; Gokhale, Vijay; Khanna, May; Khanna, Rajesh