日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure of an initiation complex of mycobacterial helicase-nuclease AdnAB at a blunt double-strand break reveals local melting that engages the 3' tracking strand at the ratchet pawl of the helicase motor

分枝杆菌解旋酶-核酸酶AdnAB起始复合物在平末端双链断裂处的结构揭示了局部解旋,该解旋酶马达的棘爪与3'追踪链结合。

Warren, Garrett M; Jason de la Cruz, M; Goldgur, Yehuda; Shuman, Stewart

Mechanism of glycoform specificity and protection against antibody dependent enhancement by an anti-afucosylated IgG nanobody

抗去岩藻糖基化IgG纳米抗体的糖型特异性及抗抗体依赖性增强作用的保护机制

Gupta, Aaron; Kao, Kevin; Yamin, Rachel; Oren, Deena A; Goldgur, Yehuda; Du, Jonathan; Lollar, Pete; Sundberg, Eric J; Ravetch, Jeffrey V

Structures of Fission Yeast Inositol Pyrophosphate Kinase Asp1 in Ligand-Free, Substrate-Bound, and Product-Bound States

裂殖酵母肌醇焦磷酸激酶Asp1在配体结合、底物结合和产物结合状态下的结构

Benjamin, Bradley; Goldgur, Yehuda; Jork, Nikolaus; Jessen, Henning J; Schwer, Beate; Shuman, Stewart

Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme

分枝杆菌DNA聚合酶I:POL结构域作为脱辅基酶和与DNA引物-模板复合物的活性和晶体结构,以及全长FEN/EXO-POL酶的晶体结构

Ghosh, Shreya; Goldgur, Yehuda; Shuman, Stewart

Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation

注意突变体:RNA连接酶中保守氨基酸被丙氨酸取代会引起赖氨酸腺苷酰化活性位点的意外重排。

Unciuleac, Mihaela-Carmen; Goldgur, Yehuda; Shuman, Stewart

Atomic structures of the RNA end-healing 5'-OH kinase and 2',3'-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor

真菌tRNA连接酶RNA末端修复5'-OH激酶和2',3'-环磷酸二酯酶结构域的原子结构:GTP磷酸供体结合后激酶的构象转变

Banerjee, Ankan; Goldgur, Yehuda; Schwer, Beate; Shuman, Stewart

Structure of Fission Yeast Transcription Factor Pho7 Bound to pho1 Promoter DNA and Effect of Pho7 Mutations on DNA Binding and Phosphate Homeostasis.

裂殖酵母转录因子 Pho7 与 pho1 启动子 DNA 结合的结构以及 Pho7 突变对 DNA 结合和磷酸盐稳态的影响

Garg Angad, Goldgur Yehuda, Sanchez Ana M, Schwer Beate, Shuman Stewart

Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities

耻垢分枝杆菌FenA的晶体结构和突变分析突显了其活性位点氨基酸和三种对瓣状核酸内切酶和5'外切酶活性至关重要的金属离子。

Uson, Maria Loressa; Carl, Ayala; Goldgur, Yehuda; Shuman, Stewart

Distinctive structural basis for DNA recognition by the fission yeast Zn2Cys6 transcription factor Pho7 and its role in phosphate homeostasis

裂殖酵母Zn2Cys6转录因子Pho7识别DNA的独特结构基础及其在磷酸盐稳态中的作用

Garg, Angad; Goldgur, Yehuda; Schwer, Beate; Shuman, Stewart

Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligase

真核生物切口密封RNA连接酶的结构和双金属机制

Unciuleac, Mihaela-Carmen; Goldgur, Yehuda; Shuman, Stewart