GWAS meta-analysis of CSF Alzheimer's disease biomarkers 18,948 individuals reveal novel loci and genes regulating lipid metabolism, brain volume and autophagy
对18948名个体脑脊液阿尔茨海默病生物标志物的全基因组关联研究荟萃分析揭示了调控脂质代谢、脑容量和自噬的新位点和基因
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doi:10.21203/rs.3.rs-6597595/v1
Cruchaga, Carlos; Timsina, Jigyasha; Jiang, Chenyang; McCartney, Daniel; Tao, Feifei; Dalmasso, Maria Carolina; Najar, Jenna; Anastasi, Federica; Ohlei, Olena; Puerta, Raquel; Bradley, Joseph; Western, Daniel; Ali, Muhammad; Wang, Ciyang; Yang, Chengran; Wu, Ying; Liu, Menghan; Budde, John; Williams, Julie; Mahoney, Rebecca; Castillo, Atahualpa; Hohman, Timothy; Dumitrescu, Logan; Wang, Ting-Chen; Tesi, Niccoló; Kern, Silke; Waern, Margda; Skoog, Ingmer; van Harten, Argonde; van der Flier, Wiesje; Sánchez-Juan, Pascual; Rodriguez-Rodriguez, Eloy; Kleineidam, Luca; Peters, Oliver; Schneider, Anja; Küçükali, Fahri; Bellenguez, Céline; Grenier-Boley, Benjamin; Heikkinen, Sami; de Rojas, Itziar; Rujescu, Dan; Scherbaum, Norbert; Hausner, Lucrezia; Duzel, Emrah; Grimmer, Timo; Wiltfang, Jens; Vandenberghe, Rik; Engelborghs, Sebastiaan; Heilmann-Heimbach, Stefanie; Schmid, Matthias; Tegos, Thomas; Scarmeas, Nikolaos; Dols-Icardo, Oriol; Moreno, Fermin; Pérez-Tur, Jordi; Bullido, María J; Sanchez-Valle, Raquel; Álvarez, Victoria; Garcia-Gonzalez, Pablo; Mir, Pablo; Real, Luis; Piñol-Ripoll, Gerard; García-Alberca, Jose María; Seelaar, Harro; Ramakers, Inez; Papma, Janne; Hulsman, Marc; Laske, Christoph; Teipel, Stefan; Priller, Josef; Perneczky, Robert; Buerger, Katharina; Nöthen, Markus; Lewczuk, Piotr; Kornhuber, Johannes; Maier, Wolfgang; Hampel, Harald; Giegling, Ina; Goldhardt, Oliver; Diehl-Schmid, Janine; Andrade, Victor; Heneka, Michael; Froelich, Lutz; Vogelgsang, Jonathan; Graff, Caroline; Thonberg, Håkan; Ullgren, Abbe; Papenberg, Goran; Boland, Anne; Deleuze, Jean-François; Wagner, Michael; Jessen, Frank; Holstege, Henne; van Duijn, Cornelia; Lebouvier, Thibaud; Hanon, Olivier; Leinonen, Ville; Soininen, Hilkka; Herukka, Sanna-Kaisa; Giedraitis, Vilmantas; Löwenmark, Malin; Kilander, Lena; Genius, Patricia; Rodríguez, Blanca; Luckett, Emma; Navarro, Arcadi; Cano, Amanda; Marquié, Marta; Blennow, Kaj; Zetterberg, Henrik; Lleo, Alberto; Boada, Mercè; Laza, Agustin Ruiz; Lee, Virginia; Deerlin, Vivianna Van; Deming, Yuetiva; Johnson, Sterling; Engelman, Corinne; Pastor, Pau; Alvarez, Ignacio; Peskind, Elaine; Heslegrave, Amanda; Saykin, Andrew; Nho, Kwangsik; Schindler, Suzanne; Morris, John; Holtzman, David; McDade, Eric; Renton, Alan; Goate, Alison; Ibanez, Laura; Riemenschneider, Matthias; Albert, Marilyn; Laws, Simon; Porter, Tenielle; O'Brien, Eleanor; Shaw, Leslie; Tijms, Betty; Ingelsson, Martin; Visser, Pieter Jelle; Hiltunen, Mikko; Sleegers, Kristel; Ritchie, Craig; Sims, Rebecca; Lambert, Jean-Charles; Vilor-Tejedor, Natàlia; Fernández, Maria; Li, Qingqin; Nagle, Michael; Marioni, Riccardo; Ramirez, Alfredo; Bertram, Lars; van der Lee, Sven
