日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanistic insights into mutation in the proton-coupled folate transporter (SLC46A1) causing hereditary folate malabsorption

对导致遗传性叶酸吸收不良的质子偶联叶酸转运蛋白(SLC46A1)突变的机制性见解

Nandigrami, Prithviraj; Goldman, I David; Fiser, Andras

Structural basis of antifolate recognition and transport by PCFT

PCFT识别和转运抗叶酸的结构基础

Parker, Joanne L; Deme, Justin C; Kuteyi, Gabriel; Wu, Zhiyi; Huo, Jiandong; Goldman, I David; Owens, Raymond J; Biggin, Philip C; Lea, Susan M; Newstead, Simon

Hereditary folate malabsorption due to a mutation in the external gate of the proton-coupled folate transporter SLC46A1

由质子偶联叶酸转运蛋白 SLC46A1 外门突变引起的遗传性叶酸吸收不良

Aluri, Srinivas; Zhao, Rongbao; Lubout, Charlotte; Goorden, Susanna M I; Fiser, Andras; Goldman, I David

Substituted-cysteine accessibility and cross-linking identify an exofacial cleft in the 7th and 8th helices of the proton-coupled folate transporter (SLC46A1)

取代半胱氨酸可及性和交联可识别质子偶联叶酸转运蛋白 (SLC46A1) 第 7 和第 8 螺旋中的外表面裂隙

Aluri, Srinivas; Zhao, Rongbao; Fiser, Andras; Goldman, I David

Concentrative Transport of Antifolates Mediated by the Proton-Coupled Folate Transporter (SLC46A1); Augmentation by a HEPES Buffer

质子偶联叶酸转运蛋白(SLC46A1)介导的抗叶酸药物浓缩转运;HEPES缓冲液增强该过程

Zhao, Rongbao; Najmi, Mitra; Aluri, Srinivas; Spray, David C; Goldman, I David

Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding.

质子偶联叶酸转运蛋白(SLC46A1)第八跨膜结构域中的残基在决定水性转运途径和叶酸底物结合中起着重要作用

Aluri Srinivas, Zhao Rongbao, Fiser Andras, Goldman I David

Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function.

色氨酸残基在质子偶联叶酸转运蛋白(PCFT-SLC46A1)功能中的作用

Najmi Mitra, Zhao Rongbao, Fiser Andras, Goldman I David

Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking.

通过半胱氨酸交联鉴定质子偶联叶酸转运蛋白(PCFT-SLC46A1)的细胞外门控

Zhao Rongbao, Najmi Mitra, Fiser Andras, Goldman I David

Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1)

鉴定增强叶酸底物结合并限制质子偶联叶酸转运蛋白(PCFT-SLC46A1)振荡的酪氨酸残基

Visentin, Michele; Unal, Ersin Selcuk; Najmi, Mitra; Fiser, Andras; Zhao, Rongbao; Goldman, I David

Determinants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis

叶酸受体介导的内吞作用将抗叶酸物质递送至细胞内,其活性的决定因素

Zhao, Rongbao; Visentin, Michele; Goldman, I David