日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genetic variants predisposing to an increased risk of kidney stone disease.

导致肾结石疾病风险增加的基因变异

Lovegrove Catherine E, Goldsworthy Michelle, Haley Jeremy, Smelser Diane, Gorvin Caroline, Hannan Fadil M, Mahajan Anubha, Suri Mohnish, Sadeghi-Alavijeh Omid, Moochhala Shabbir H, Gale Daniel P, Carey David, Holmes Michael V, Furniss Dominic, Thakker Rajesh V, Howles Sarah A

Central Adiposity Increases Risk of Kidney Stone Disease through Effects on Serum Calcium Concentrations

中心性肥胖通过影响血清钙浓度增加肾结石风险

Lovegrove, Catherine E; Bešević, Jelena; Wiberg, Akira; Lacey, Ben; Littlejohns, Thomas J; Allen, Naomi E; Goldsworthy, Michelle; Kim, Jihye; Hannan, Fadil M; Curhan, Gary C; Turney, Ben W; McCarthy, Mark I; Mahajan, Anubha; Thakker, Rajesh V; Holmes, Michael V; Furniss, Dominic; Howles, Sarah A

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease

通过小鼠诱变筛选揭示了与年龄相关疾病模型的新基因功能

Potter, Paul K; Bowl, Michael R; Jeyarajan, Prashanthini; Wisby, Laura; Blease, Andrew; Goldsworthy, Michelle E; Simon, Michelle M; Greenaway, Simon; Michel, Vincent; Barnard, Alun; Aguilar, Carlos; Agnew, Thomas; Banks, Gareth; Blake, Andrew; Chessum, Lauren; Dorning, Joanne; Falcone, Sara; Goosey, Laurence; Harris, Shelley; Haynes, Andy; Heise, Ines; Hillier, Rosie; Hough, Tertius; Hoslin, Angela; Hutchison, Marie; King, Ruairidh; Kumar, Saumya; Lad, Heena V; Law, Gemma; MacLaren, Robert E; Morse, Susan; Nicol, Thomas; Parker, Andrew; Pickford, Karen; Sethi, Siddharth; Starbuck, Becky; Stelma, Femke; Cheeseman, Michael; Cross, Sally H; Foster, Russell G; Jackson, Ian J; Peirson, Stuart N; Thakker, Rajesh V; Vincent, Tonia; Scudamore, Cheryl; Wells, Sara; El-Amraoui, Aziz; Petit, Christine; Acevedo-Arozena, Abraham; Nolan, Patrick M; Cox, Roger; Mallon, Anne-Marie; Brown, Steve D M

Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes

Ppp2r2a剪接位点突变导致胰岛素受体单倍体功能不全,从而产生一种新型的2型糖尿病双基因小鼠模型。

Goldsworthy, Michelle; Bai, Ying; Li, Chi-Ming; Ge, Huanying; Lamas, Edwin; Hilton, Helen; Esapa, Christopher T; Baker, Dan; Baron, Will; Juan, Todd; Véniant, Murielle M; Lloyd, David J; Cox, Roger D

Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion

糖尿病基因SOX4表达增加通过损害融合孔扩张来减少胰岛素分泌

Collins, Stephan C; Do, Hyun Woong; Hastoy, Benoit; Hugill, Alison; Adam, Julie; Chibalina, Margarita V; Galvanovskis, Juris; Godazgar, Mahdieh; Lee, Sheena; Goldsworthy, Michelle; Salehi, Albert; Tarasov, Andrei I; Rosengren, Anders H; Cox, Roger; Rorsman, Patrik

Modelling age-related metabolic disorders in the mouse

小鼠年龄相关代谢紊乱模型

Goldsworthy, Michelle E; Potter, Paul K

Insulin secretion from beta-cells is affected by deletion of nicotinamide nucleotide transhydrogenase

β细胞分泌胰岛素受烟酰胺核苷酸转氢酶缺失的影响

Shimomura, Kenju; Galvanovskis, Juris; Goldsworthy, Michelle; Hugill, Alison; Kaizak, Stephan; Lee, Angela; Meadows, Nicholas; Quwailid, Mohamed Mohideen; Rydström, Jan; Teboul, Lydia; Ashcroft, Fran; Cox, Roger D