Gomez Kimberly相关文献与解析，生知库 | 链接生命科学的每一步

Small molecule targeting Na V 1.7 via inhibition of CRMP2-Ubc9 interaction reduces pain-related outcomes in a rodent osteoarthritic model.

通过抑制 CRMP2-Ubc9 相互作用靶向 Na V 1.7 的小分子可减轻啮齿动物骨关节炎模型中的疼痛相关结果

doi:10.1097/j.pain.0000000000003357

Hestehave Sara, Allen Heather N, Gomez Kimberly, Duran Paz, Calderon-Rivera Aida, Loya-LÃ³pez Santiago, RodrÃguez-Palma Erick J, Khanna Rajesh

Quinoline-Based Neuropilin‑1 Antagonists Exhibit a Pure Antagonist Profile and Block Vascular Endothelial Growth Factor-Induced Pain

基于喹啉的神经纤毛蛋白-1拮抗剂表现出纯拮抗剂特性，并能阻断血管内皮生长因子诱导的疼痛。

期刊:ACS Pharmacology and Translational Science

影响因子:3.7

doi:10.1021/acsptsci.5c00029

Hestehave, Sara; Dragoni, Silvia; Fallon, Philip; Mota, Filipa; Calderon-Rivera, Aida; Gomez, Kimberly; Powell, Jonathan; Patsiarika, Anastasia; Reisinger, Tifelle; Crosby, Stuart; Chan, A W Edith; Steadman, David; Winfield, Natalie; Jarvis, Ashley; Martin, John; Zachary, Ian C; Frankel, Paul; Djordjevic, Snezana; Ruhrberg, Christiana; Khanna, Rajesh; Selwood, David L

心血管

发表日期：2025

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Targeting Na(v)1.7 and Na(v)1.8 with a PIKfyve inhibitor to reverse inflammatory and neuropathic pain.

使用 PIKfyve 抑制剂靶向 Na(v)1.7 和 Na(v)1.8 来逆转炎症性和神经性疼痛

期刊:Neurobiology of Pain

影响因子:3.2

doi:10.1016/j.ynpai.2024.100174

RodrÃguez-Palma Erick J, Loya-Lopez Santiago, Min Sophia M, Calderon-Rivera Aida, Gomez Kimberly, Khanna Rajesh, Axtman Alison D

R and S enantiomers of CBD3063, a Ca(V)2.2Â N-type calcium channel modulator, alleviate capsaicin-induced inflammatory pain.

CBD3063 的 R 和 S 对映体（一种 Ca(V)2.2Â N 型钙通道调节剂）可缓解辣椒素引起的炎症疼痛

期刊:Neurobiology of Pain

影响因子:3.2

doi:10.1016/j.ynpai.2025.100185

Loya-LÃ³pez Santiago, RodrÃguez-Palma Erick J, CalderÃ³n-Rivera Aida, Gomez Kimberly, Perez-Miller Samantha, Khanna Rajesh

Enabling wider access to human molecular neuroscience research in pain: A simple preservation method for human dorsal root ganglion neurons in Hibernate A media.

使人类疼痛分子神经科学研究能够更广泛地进行：一种在 Hibernate A 培养基中保存人类背根神经节神经元的简单方法。

期刊:

影响因子:

doi:10.1101/2025.09.06.674648

Lesnak Joseph B, Schaub Mandee K, Gomez Kimberly, Calderon-Rivera Aida, Loya-Lopez Santiago, Stewart Robert, Jo Sooyeon, Fujita Akie, Osorno TomÃ¡s, Desai Marisa, Natarajan Keerthana, Schackmuth Morgan K, Moreno Marisol Mancilla, Shiers Stephanie I, Cervantes Anna, Funk Geoffrey, Horton Peter, Vines Erin, Yousuf Muhammad Saad, Sadler Katelyn E, Bean Bruce P, Khanna Rajesh, Dussor Gregory, Price Theodore J

神经科学

发表日期：2025

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CNS‐active drugs for neuropsychiatric disorders differentially modulate the risk of AD development

用于治疗神经精神疾病的中枢神经系统活性药物对阿尔茨海默病（AD）的发生风险具有不同的调节作用。

期刊:Science Translational Medicine

影响因子:14.6

doi:10.1126/scitranslmed.abh1314

Cai, Song; Moutal, Aubin; Yu, Jie; Chew, Lindsey A; Isensee, Jörg; Chawla, Reena; Gomez, Kimberly; Luo, Shizhen; Zhou, Yuan; Chefdeville, Aude; Madura, Cynthia; Perez-Miller, Samantha; Bellampalli, Shreya Sai; Dorame, Angie; Scott, David D; François-Moutal, Liberty; Shan, Zhiming; Woodward, Taylor; Gokhale, Vijay; Hohmann, Andrea G; Vanderah, Todd W; Patek, Marcel; Khanna, May; Hucho, Tim; Khanna, Rajesh; Cortes‐Flores, Helena; Torrandell‐Haro, Georgina; Brinton, Roberta Diaz

Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models

神经纤毛蛋白-1抑制剂可抑制疼痛模型中的神经生长因子信号传导和伤害感受。

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI183873

Peach, Chloe J; Tonello, Raquel; Damo, Elisa; Gomez, Kimberly; Calderon-Rivera, Aida; Bruni, Renato; Bansia, Harsh; Maile, Laura; Manu, Ana-Maria; Hahn, Hyunggu; Thomsen, Alex Rb; Schmidt, Brian L; Davidson, Steve; des Georges, Amedee; Khanna, Rajesh; Bunnett, Nigel W

信号转导

发表日期：2024

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C2230, a preferential use- and state-dependent CaV2.2 channel blocker, mitigates pain behaviors across multiple pain models.

C2230 是一种优先使用和状态依赖的 CaV2.2 通道阻滞剂，可减轻多种疼痛模型中的疼痛行为

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI177429

Tang Cheng, Gomez Kimberly, Chen Yan, Allen Heather N, Hestehave Sara, RodrÃguez-Palma Erick J, Loya-Lopez Santiago, Calderon-Rivera Aida, Duran Paz, Nelson Tyler S, Kanumuri Siva Rama Raju, Shah Bijal, Panigrahi Nihar R, Perez-Miller Samantha, Schackmuth Morgan K, Ruparel Shivani, Patwardhan Amol, Price Theodore J, Arora Paramjit S, Sharma Ravindra K, Sharma Abhisheak, Yu Jie, Korczeniewska Olga A, Khanna Rajesh

其它

发表日期：2024

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Context dependent roles of FGF13B-Na(V)1.7 interaction in pain signaling

FGF13B-Na(V)1.7 相互作用在疼痛信号传导中的上下文依赖性作用

"N-credible": how a tiny viral protein is turning pain into a long-term gig

“N-credible”：一种微小的病毒蛋白如何将痛苦转化为长期的职业

Small molecule targeting Na V 1.7 via inhibition of CRMP2-Ubc9 interaction reduces pain-related outcomes in a rodent osteoarthritic model.

通过抑制 CRMP2-Ubc9 相互作用靶向 Na V 1.7 的小分子可减轻啮齿动物骨关节炎模型中的疼痛相关结果

Quinoline-Based Neuropilin‑1 Antagonists Exhibit a Pure Antagonist Profile and Block Vascular Endothelial Growth Factor-Induced Pain

基于喹啉的神经纤毛蛋白-1拮抗剂表现出纯拮抗剂特性，并能阻断血管内皮生长因子诱导的疼痛。

Targeting Na(v)1.7 and Na(v)1.8 with a PIKfyve inhibitor to reverse inflammatory and neuropathic pain.

使用 PIKfyve 抑制剂靶向 Na(v)1.7 和 Na(v)1.8 来逆转炎症性和神经性疼痛

R and S enantiomers of CBD3063, a Ca(V)2.2Â N-type calcium channel modulator, alleviate capsaicin-induced inflammatory pain.

CBD3063 的 R 和 S 对映体（一种 Ca(V)2.2Â N 型钙通道调节剂）可缓解辣椒素引起的炎症疼痛

Enabling wider access to human molecular neuroscience research in pain: A simple preservation method for human dorsal root ganglion neurons in Hibernate A media.

使人类疼痛分子神经科学研究能够更广泛地进行：一种在 Hibernate A 培养基中保存人类背根神经节神经元的简单方法。

CNS‐active drugs for neuropsychiatric disorders differentially modulate the risk of AD development

用于治疗神经精神疾病的中枢神经系统活性药物对阿尔茨海默病（AD）的发生风险具有不同的调节作用。

Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models

神经纤毛蛋白-1抑制剂可抑制疼痛模型中的神经生长因子信号传导和伤害感受。

C2230, a preferential use- and state-dependent CaV2.2 channel blocker, mitigates pain behaviors across multiple pain models.

C2230 是一种优先使用和状态依赖的 CaV2.2 通道阻滞剂，可减轻多种疼痛模型中的疼痛行为