日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural and mechanistic insights into regulation of the retromer coat by TBC1d5

TBC1d5对逆转录酶外壳调控的结构和机制研究

Jia, Da; Zhang, Jin-San; Li, Fang; Wang, Jing; Deng, Zhihui; White, Mark A; Osborne, Douglas G; Phillips-Krawczak, Christine; Gomez, Timothy S; Li, Haiying; Singla, Amika; Burstein, Ezra; Billadeau, Daniel D; Rosen, Michael K

Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming

树突状细胞利用进化上保守的WASH和逆转录酶复合物来促进MHCII的再循环和辅助性T细胞的启动。

Graham, Daniel B; Osborne, Douglas G; Piotrowski, Joshua T; Gomez, Timothy S; Gmyrek, Grzegorz B; Akilesh, Holly M; Dani, Adish; Billadeau, Daniel D; Swat, Wojciech

The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics

细胞骨架衔接蛋白IQGAP1调节TCR介导的信号传导和丝状肌动蛋白动力学

Gorman, Jacquelyn A; Babich, Alexander; Dick, Christopher J; Schoon, Renee A; Koenig, Alexander; Gomez, Timothy S; Burkhardt, Janis K; Billadeau, Daniel D

Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells.

造血谱系细胞特异性蛋白 1 与 Wiskott-Aldrich 综合征蛋白协同作用,促进树突状细胞中足突阵列的组织和趋化性

Dehring Deborah A Klos, Clarke Fiona, Ricart Brendon G, Huang Yanping, Gomez Timothy S, Williamson Edward K, Hammer Daniel A, Billadeau Daniel D, Argon Yair, Burkhardt Janis K

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

Wiskott-Aldrich综合征蛋白(WASP)家族的WASH和WAVE肌动蛋白调节因子受结构相关的类似复合物控制。

Jia, Da; Gomez, Timothy S; Metlagel, Zoltan; Umetani, Junko; Otwinowski, Zbyszek; Rosen, Michael K; Billadeau, Daniel D

Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy.

蛋白激酶 Cβ 调节配体诱导的细胞表面死亡受体积累:恩扎司他汀-死亡配体协同作用的机制基础

Meng Xue Wei, Heldebrant Michael P, Flatten Karen S, Loegering David A, Dai Haiming, Schneider Paula A, Gomez Timothy S, Peterson Kevin L, Trushin Sergey A, Hess Allan D, Smith B Douglas, Karp Judith E, Billadeau Daniel D, Kaufmann Scott H

A FAM21-containing WASH complex regulates retromer-dependent sorting

含FAM21的WASH复合物调控逆转录酶依赖性分选

Gomez, Timothy S; Billadeau, Daniel D

Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading

造血谱系细胞特异性蛋白1被IL-2诱导的T细胞激酶募集到免疫突触,并在T细胞扩散过程中调节磷脂酶Cγ1微簇的动态变化。

Carrizosa, Esteban; Gomez, Timothy S; Labno, Christine M; Klos Dehring, Deborah A; Liu, Xiaohong; Freedman, Bruce D; Billadeau, Daniel D; Burkhardt, Janis K

Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse

形成蛋白调节中心体向免疫突触的非肌动蛋白相关蛋白2/3复合物依赖性极化

Gomez, Timothy S; Kumar, Karan; Medeiros, Ricardo B; Shimizu, Yoji; Leibson, Paul J; Billadeau, Daniel D

HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse

HS1 在免疫突触中发挥着重要的肌动蛋白调节衔接蛋白的作用。

Gomez, Timothy S; McCarney, Sean D; Carrizosa, Esteban; Labno, Christine M; Comiskey, Erin O; Nolz, Jeffrey C; Zhu, Peimin; Freedman, Bruce D; Clark, Marcus R; Rawlings, David J; Billadeau, Daniel D; Burkhardt, Janis K