Aerobic exercise facilitates p300 nuclear translocation via ADRB2-AMPKα signaling, leading to enhanced histone acetylation and mitigation of cognitive decline in APP/PS1 mice.
有氧运动通过 ADRB2-AMPKα 信号传导促进 p300 核转位，从而增强组蛋白乙酰化并减轻 APP/PS1 小鼠的认知衰退。
期刊:Alzheimers Research & Therapy
影响因子:7.6
doi:10.1186/s13195-026-01983-z
Chai Gao-Shang, Gao Tian-Long, Bi Shu-Guang, Mao Yu-Ming, Yang Liu, Wang Fang-Zhou, Chen Jia, Wu Jia-Jun, Gong Juan, Geng Shan, Yuan Jia-Qi, Zhang Ke-Yu, Yi Hai-Yan, Lan Zi-Chong, Nie Yun-Juan, Yu Haitao
