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日期影响因子

Inhibiting HSP27 activates the XBP1s/CerS1 interplay, which triggers DRP1-driven mitophagy, thereby protecting against cell death and promoting the KSHV lytic cycle in primary effusion lymphoma cells.

抑制 HSP27 可激活 XBP1s/CerS1 相互作用，从而触发 DRP1 驱动的线粒体自噬，进而保护细胞免于死亡，并促进原发性渗出性淋巴瘤细胞中的 KSHV 裂解周期。

期刊:Cell Death Discovery

doi:10.1038/s41420-026-02979-2

Gonnella Roberta, Corrado Vincenzo, Scaffidi Giulio Francesco, Benedetti Rossella, Di Crosta Michele, Zarrella Roberta, Gilardini Montani Maria Saveria, Santarelli Roberta, Cirone Mara

细胞生物学

发表日期：2026

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HHV-6A Drives Epigenetic Reprogramming via an EZH2-SIRT1 Axis to Sustain Mutant p53 and Reshape Oncogenic Inflammatory Signaling

HHV-6A 通过 EZH2-SIRT1 轴驱动表观遗传重编程，以维持突变型 p53 并重塑致癌炎症信号通路

期刊:Viruses-Basel

影响因子:3.5

doi:10.3390/v18040409

Benedetti, Rossella; Di Crosta, Michele; Stirparo, Alessia; Aron, George Alexandru; Mardente, Stefania; Santarelli, Roberta; Gonnella, Roberta; Gilardini Montani, Maria Saveria; Cirone, Mara

发表日期：2026

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Acetylation promotes mutant (MUT) TP53-HSPA8 and HSPA8-BAG3 interactions, facilitating MUT TP53 lysosomal degradation preferentially via CASA

乙酰化促进突变型（MUT）TP53-HSPA8和HSPA8-BAG3相互作用，从而优先通过CASA途径促进MUT TP53溶酶体降解。

期刊:Autophagy

影响因子:14.3

doi:10.1080/15548627.2025.2576615

Di Crosta, Michele; Ragone, Francesca Chiara; Benedetti, Rossella; D'Orazi, Gabriella; Santarelli, Roberta; Gonnella, Roberta; Gilardini Montani, Maria Saveria; Cirone, Mara

发表日期：2025

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Modulatory Effect of Curcumin on Expression of Methyltransferase/Demethylase in Colon Cancer Cells: Impact on wt p53, mutp53 and c-Myc.

姜黄素对结肠癌细胞中甲基转移酶/去甲基酶表达的调节作用：对野生型 p53、突变型 p53 和 c-Myc 的影响

期刊:Molecules

影响因子:4.6

doi:10.3390/molecules30153054

Santarelli Roberta, Di Dio Claudia, Di Crosta Michele, CurrÃ Paola, Gonnella Roberta, Cirone Mara

细胞生物学

发表日期：2025

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The inhibition of IRE1alpha/XBP1 axis prevents EBV-driven lymphomagenesis in NSG mice

抑制IRE1α/XBP1轴可阻止NSG小鼠中EBV驱动的淋巴瘤发生。

期刊:Microbiology Spectrum

影响因子:3.8

doi:10.1128/spectrum.02636-23

Arena, Andrea; Romeo, Maria Anele; Po, Agnese; Benedetti, Rossella; Gilardini Montani, Maria Saveria; Gonnella, Roberta; Santarelli, Roberta; Gaeta, Aurelia; De Smaele, Enrico; Cirone, Mara

发表日期：2023

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NRF2 and STAT3: friends or foes in carcinogenesis?

NRF2 和 STAT3：致癌过程中的朋友还是敌人？

期刊:Discover Oncology

影响因子:2.9

doi:10.1007/s12672-023-00644-z

Arena, Andrea; Romeo, Maria Anele; Benedetti, Rossella; Gilardini Montani, Maria Saveria; Santarelli, Roberta; Gonnella, Roberta; D'Orazi, Gabriella; Cirone, Mara

发表日期：2023

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NFE2L2 and STAT3 Converge on Common Targets to Promote Survival of Primary Lymphoma Cells

NFE2L2 和 STAT3 汇聚于共同靶点，促进原发性淋巴瘤细胞存活

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms241411598

Andrea Arena, Michele Di Crosta, Roberta Gonnella, Roberta Zarrella, Maria Anele Romeo, Rossella Benedetti, Maria Saveria Gilardini Montani, Roberta Santarelli, Gabriella D'Orazi, Mara Cirone

发表日期：2023

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HSP110 Inhibition in Primary Effusion Lymphoma Cells: One Molecule, Many Pro-Survival Targets

原发性渗出性淋巴瘤细胞中的 HSP110 抑制：一个分子，多个促生存靶点

doi:10.3390/cancers15235651

Roberta Gonnella, Roberta Zarrella, Michele Di Crosta, Rossella Benedetti, Andrea Arena, Roberta Santarelli, Maria Saveria Gilardini Montani, Gabriella D'Orazi, Mara Cirone

发表日期：2023

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Mechanisms of Sensitivity and Resistance of Primary Effusion Lymphoma to Dimethyl Fumarate (DMF)

原发性渗出性淋巴瘤对富马酸二甲酯（DMF）的敏感性和耐药性机制

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms23126773

Roberta Gonnella, Roberta Zarrella, Roberta Santarelli, Concetta Anna Germano, Maria Saveria Gilardini Montani, Mara Cirone

发表日期：2022

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Concomitant Inhibition of IRE1α/XBP1 Axis of UPR and PARP: A Promising Therapeutic Approach against c-Myc and Gammaherpesvirus-Driven B-Cell Lymphomas

同时抑制 UPR 和 PARP 的 IRE1α/XBP1 轴：一种针对 c-Myc 和伽马疱疹病毒驱动的 B 细胞淋巴瘤的有前景的治疗方法

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms23169113

Rossella Benedetti, Andrea Arena, Maria Anele Romeo, Maria Saveria Gilardini Montani, Roberta Gonnella, Roberta Santarelli, Pankaj Trivedi, Mara Cirone

发表日期：2022

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