日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

FoxO1-zDHHC4-CD36 S-Acylation Axis Drives Metabolic Dysfunction in Diabetes

FoxO1-zDHHC4-CD36 S-酰化轴驱动糖尿病代谢功能障碍

Dennis, Kaitlyn M J H; Gopal, Keshav; Montes Aparicio, Claudia N; Zhang, Jiashuo Aaron; Castro-Guarda, Marcos; Nicol, Thomas; Devereux, Ríona M; Carter, Ryan D; Azizi, Saara-Anne; Lan, Tong; Purnama, Ujang; Carr, Carolyn A; Simsek, Gul; Gill, Eleanor K; Swietach, Pawel; Sorop, Oana; Heinonen, Ilkka H A; Schianchi, Francesco; Luiken, Joost J F P; Aksentijevic, Dunja; Duncker, Dirk J; Dickinson, Bryan C; De Val, Sarah; Ussher, John R; Fuller, William; Heather, Lisa C

Cardioprotective effect of 19,20-epoxydocosapentaenoic acid (19,20-EDP) in ischaemic injury involves direct activation of mitochondrial sirtuin 3

19,20-环氧二十二碳五烯酸 (19,20-EDP) 在缺血性损伤中的心脏保护作用涉及线粒体 sirtuin 3 的直接激活

Darwesh, Ahmed M; Fang, Liye; Altamimi, Tariq R; Jamieson, K Lockhart; Bassiouni, Wesam; Valencia, Robert; Huang, Andy; Wang, Faqi; Zhang, Hao; Ahmed, Marawan; Gopal, Keshav; Zhang, Yongneng; Michelakis, Evangelos D; Ussher, John R; Edin, Matthew L; Zeldin, Darryl C; Barakat, Khaled; Oudit, Gavin Y; Kassiri, Zamaneh; Lopaschuk, Gary D; Seubert, John M

Development of a succinyl CoA:3-ketoacid CoA transferase inhibitor selective for peripheral tissues that improves glycemia in obesity.

开发一种对周围组织具有选择性的琥珀酰辅酶A:3-酮酸辅酶A转移酶抑制剂,可改善肥胖症患者的血糖水平

Tabatabaei Dakhili Seyed Amirhossein, Yang Kunyan, Al Nebaihi Hamdah, Greenwell Amanda A, Wuest Melinda, Woodfield Jenilee, Farraj Rabih Abou, Saed Christina T, Chan Jordan S F, Bhat Rakesh K, Mangra-Bala Indiresh A, Shafaati Tanin, Gopal Keshav, Eaton Farah, Ferrari Sally R, Wagg Cory S, Capozzi Megan E, Campbell Jonathan E, Overduin Michael, Velazquez-Martinez Carlos A, Glover J N Mark, Wuest Frank, Brocks Dion R, Ussher John R

Metformin alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy

二甲双胍可缓解实验性糖尿病心肌病小鼠的舒张功能障碍

Chan, Jordan S F; Tabatabaei Dakhili, Seyed Amirhossein; Wu, Nadeen R; Stenlund, Magnus J; King, Alexa N; Dong, Linyue; Mangra-Bala, Indiresh A; Shafaati, Tanin; Ferrari, Sally R; Greenwell, Amanda A; Yang, Kunyan; Saed, Christina T; Eaton, Farah; Gopal, Keshav; Steinberg, Gregory R; Dyck, Jason R B; Ussher, John R

Pharmacological increases in circulating ketones fail to alleviate the hypertrophic cardiomyopathy present in the Tafazzin knockdown mouse model of Barth syndrome

药物提高循环酮体水平未能缓解巴特综合征Tafazzin基因敲除小鼠模型中存在的肥厚型心肌病。

Shafaati, Tanin; Greenwell, Amanda A; Saed, Christina T; Tabatabaei Dakhili, Seyed Amirhossein; Chan, Jordan S F; Dong, Linyue; Stenlund, Magnus J; Ferrari, Sally R; Han, Ruth; Kruger, Jennifer; Eaton, Farah; Gopal, Keshav; Davidge, Sandra T; Oudit, Gavin Y; Ussher, John R

Redefining Diabetic Cardiomyopathy: Perturbations in Substrate Metabolism at the Heart of Its Pathology

重新定义糖尿病心肌病:底物代谢紊乱是其病理的核心

Heather, Lisa C; Gopal, Keshav; Srnic, Nikola; Ussher, John R

Pharmacological Inhibition of Succinyl Coenzyme A:3-Ketoacid Coenzyme A Transferase Alleviates the Progression of Diabetic Cardiomyopathy

琥珀酰辅酶A:3-酮酸辅酶A转移酶的药理学抑制可缓解糖尿病心肌病的进展

Greenwell, Amanda A; Tabatabaei Dakhili, Seyed Amirhossein; Wagg, Cory S; Saed, Christina T; Chan, Jordan S F; Yang, Kunyan; Mangra-Bala, Indiresh A; Stenlund, Magnus J; Eaton, Farah; Gopal, Keshav; Dyck, Jason R B; Lopaschuk, Gary D; Ussher, John R

Forkhead box O1 transcription factor; a therapeutic target for diabetic cardiomyopathy

叉头框O1转录因子;糖尿病心肌病的治疗靶点

Shafaati, Tanin; Gopal, Keshav

Myocardial Energy Metabolism in Non-ischemic Cardiomyopathy

非缺血性心肌病中的心肌能量代谢

Greenwell, Amanda A; Gopal, Keshav; Ussher, John R

Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency

酮体氧化增加可为衰竭的心脏提供额外能量,但并不能提高心脏效率。

Ho, Kim L; Zhang, Liyan; Wagg, Cory; Al Batran, Rami; Gopal, Keshav; Levasseur, Jody; Leone, Teresa; Dyck, Jason R B; Ussher, John R; Muoio, Deborah M; Kelly, Daniel P; Lopaschuk, Gary D